TFAM

Transcription factor A, mitochondrial · Q00059 · TFAM on Sugi Atlas →

0 patent compounds predicted against TFAM, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to TFAM by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients PHASE4UNKNOWN
Empagliflozin Effect on Glucose Toxicity PHASE4WITHDRAWN
TAKE TIME Pioglitazone Reverses Defects in Mitochondrial Biogenesis in Patients With T2DM PHASE4COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome PHASE2RECRUITING
Rosiglitazone to Reverse Metabolic Defects in Diabetes PHASE2COMPLETED
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC PHASE2NOT_YET_RECRUITING
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA) EARLY_PHASE1COMPLETED
Nicotinamide Riboside in LVAD Recipients EARLY_PHASE1COMPLETED
Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer nanACTIVE_NOT_RECRUITING
Role of Mitochondria in Non Severe Asthma nanCOMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure? nanRECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility nanRECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2 nanUNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Human Mitochondrial Stress-driven Obesity Resistance nanCOMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis nanUNKNOWN
Immune Responses With Reduxium nanCOMPLETED
Natural History in Primary Mitochondrial Myopathies nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TFAM binder may also engage these)

ProteinNameSimilarity
Q4H0T5 0.999 Q4H0T5 →
Q91ZW1 0.996 Q91ZW1 →
P40630 0.994 P40630 →
Q5D144 0.989 Q5D144 →
Q0II87 0.985 Q0II87 →
Q6DIJ5 0.964 Q6DIJ5 →
Q6AZF8 0.964 Q6AZF8 →
Q52LW3 0.964 Q52LW3 →
P0CB47 0.964 P0CB47 →
FASTKD5 FAST kinase domain-containing protein 5, mitochondrial 0.964 landscape →
Q95KD0 0.963 Q95KD0 →
P0CB48 0.963 P0CB48 →
Q9DC33 0.962 Q9DC33 →
Q8C9J3 0.962 Q8C9J3 →
Q5SSK3 0.962 Q5SSK3 →
Q8VD46 0.962 Q8VD46 →
P25976 0.962 P25976 →
Q2IBF5 0.962 Q2IBF5 →
Q5PQJ5 0.961 Q5PQJ5 →
Q4KM51 0.961 Q4KM51 →
Q07DZ7 0.961 Q07DZ7 →
Q2IBB1 0.961 Q2IBB1 →
Q0P4D6 0.961 Q0P4D6 →
Q9NP66 0.960 Q9NP66 →
Q5RFI6 0.960 Q5RFI6 →
Q4R8R3 0.960 Q4R8R3 →
P25977 0.960 P25977 →
Q07DY6 0.960 Q07DY6 →
Q09YH1 0.960 Q09YH1 →
Q8NE18 0.960 Q8NE18 →