TGFB1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Vactosertib (SCHEMBL250076)	1.00	1/20
SCHEMBL248684	0.89	1/20
Ly-3200882 (SCHEMBL17645407)	0.87	1/20
SCHEMBL248262	0.84	1/20
SCHEMBL19492123	0.83	1/20
SCHEMBL22903519	0.82	1/20
SCHEMBL22903520	0.82	1/20
SCHEMBL249547	0.81	1/20
SCHEMBL249067	0.81	1/20
SCHEMBL249408	0.81	1/20
SCHEMBL250109	0.81	1/20
SCHEMBL19492293	0.81	1/20
SCHEMBL22546067	0.81	1/20
SCHEMBL250059	0.80	1/20
SCHEMBL246830	0.80	1/20
SCHEMBL17645432	0.79	1/20
SCHEMBL248193	0.79	1/20
SCHEMBL249978	0.79	1/20
SCHEMBL3439270	0.79	1/20
SCHEMBL3439090	0.78	1/20

Clinical trials — most relevant to TGFB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Diurnal Variation of Plasminogen Activator Inhibitor-1	PHASE4	COMPLETED
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN)	PHASE4	COMPLETED
Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD	PHASE4	UNKNOWN
REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrs	PHASE4	COMPLETED
Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study	PHASE4	COMPLETED
Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients	PHASE2/PHASE3	UNKNOWN
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients	PHASE3	UNKNOWN
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Prevention of Kidney Transplant Rejection	PHASE3	COMPLETED
PCSK 9 Inhibition as Secondary Prevention in Renal Transplant Patients	PHASE3	COMPLETED
Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis	PHASE2	COMPLETED
Losartan Versus Atenolol for the Treatment of Marfan Syndrome	PHASE2	COMPLETED
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor	PHASE1/PHASE2	COMPLETED
Part 2 of Phase 1 Study of GC1008 to Treat Advanced Melanoma (Part 2 Will Only Accept and Treat Patients With Advanced Malignant Melanoma)	PHASE1	COMPLETED
Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis	nan	UNKNOWN
Investigation of Substrates Associated With the Recurrence of Atrial Fibrillation After PV Cryoablation	nan	COMPLETED
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System	nan	COMPLETED
Angiotensin II Antagonism of TGF-Beta 1	nan	COMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection	nan	UNKNOWN
Sex Hormones and Blood PCSK9 Levels	nan	COMPLETED
Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension	nan	ACTIVE_NOT_RECRUITING
Vascular Markers During OGTT in Diabetics and First-degree Relatives	nan	COMPLETED
Clinical and Basic Research on the Necessity of Scar Tissue Resection During Intrauterine Adhesions	nan	UNKNOWN
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Role of Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention	nan	UNKNOWN
Supplementation With Vitamin D Improves Leptin Resistance	nan	UNKNOWN
Biomarker Levels During Indwelling Pleural cAtheter Sample Testing	nan	ENROLLING_BY_INVITATION
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Extra Alirocumab in Addition to Statin Therapy in Symptomatic IntraCranial Atherosclerotic Stenosis ----a Pilot Study	nan	UNKNOWN
The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TGFB1 binder may also engage these)

Protein	Name	Similarity
P54831	—	1.000	P54831 →
P17246	—	1.000	P17246 →
O19011	—	1.000	O19011 →
P50414	—	1.000	P50414 →
P04202	—	1.000	P04202 →
P09533	—	1.000	P09533 →
Q38HS2	—	1.000	Q38HS2 →
P18341	—	1.000	P18341 →
Q9Z1Y6	—	1.000	Q9Z1Y6 →
P07200	—	1.000	P07200 →
Q6X2S4	—	0.985	Q6X2S4 →
P43032	—	0.984	P43032 →
Q04998	—	0.984	Q04998 →
P08476	—	0.984	P08476 →
P27092	—	0.984	P27092 →
P18331	—	0.983	P18331 →
Q64280	—	0.983	Q64280 →
P17125	—	0.982	P17125 →
P16047	—	0.982	P16047 →
P03970	—	0.982	P03970 →
A8WCC4	—	0.981	A8WCC4 →
P55102	—	0.981	P55102 →
Q07257	—	0.980	Q07257 →
Q07258	—	0.980	Q07258 →
Q9I946	—	0.980	Q9I946 →
P10600	—	0.980	P10600 →
P07995	—	0.980	P07995 →
P09531	—	0.979	P09531 →
P18075	—	0.978	P18075 →
P17491	—	0.978	P17491 →