TRAP1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL872294	0.55	17/20
SCHEMBL873984	0.70	12/20
SCHEMBL1052264	0.73	9/20
SCHEMBL1059521	0.71	9/20
SCHEMBL1060436	0.66	9/20
SCHEMBL1059740	0.66	9/20
SCHEMBL1058173	0.64	9/20
SCHEMBL1060637	0.63	9/20
SCHEMBL1079346	0.60	9/20
SCHEMBL1059052	0.59	9/20
SCHEMBL1057826	0.59	9/20
SCHEMBL1059577	0.59	9/20
SCHEMBL1078262	0.57	9/20
SCHEMBL1083386	0.57	9/20
SCHEMBL1054540	0.57	9/20
SCHEMBL1060933	0.56	9/20
SCHEMBL1080760	0.56	9/20
SCHEMBL1053982	0.55	9/20
SCHEMBL1059998	0.54	9/20
SCHEMBL1054374	0.52	9/20

Clinical trials — most relevant to TRAP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin	PHASE2/PHASE3	UNKNOWN
Biologic Correlative Taxotere/AC	PHASE2	COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies	PHASE1	WITHDRAWN
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)	EARLY_PHASE1	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective	nan	COMPLETED
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk	nan	COMPLETED
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Perfusion-Induced Hyperthermia for Metastatic Carcinoma	nan	COMPLETED
Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC	nan	COMPLETED
Influence of Diabetic Neuropathy on Activation of Brown Adipose Tissue	nan	UNKNOWN
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Autologous Mitochondrial Transplant for Cerebral Ischemia	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TRAP1 binder may also engage these)

Protein	Name	Similarity
Q5XHZ0	—	1.000	Q5XHZ0 →
Q2TBI4	—	1.000	Q2TBI4 →
Q9CQN1	—	1.000	Q9CQN1 →
Q3B3E6	—	0.997	Q3B3E6 →
Q883Y9	—	0.997	Q883Y9 →
C3K6N7	—	0.996	C3K6N7 →
Q4KFX8	—	0.996	Q4KFX8 →
Q7WC32	—	0.995	Q7WC32 →
Q1QUL4	—	0.995	Q1QUL4 →
Q21IX0	—	0.995	Q21IX0 →
Q48K64	—	0.995	Q48K64 →
Q0I2A3	—	0.995	Q0I2A3 →
Q8PJK3	—	0.994	Q8PJK3 →
A1WXE4	—	0.994	A1WXE4 →
A4SLY0	—	0.994	A4SLY0 →
Q3SNS6	—	0.994	Q3SNS6 →
P54649	—	0.994	P54649 →
Q8P855	—	0.993	Q8P855 →
P61185	—	0.993	P61185 →
Q2P2U8	—	0.993	Q2P2U8 →
Q1H2K2	—	0.993	Q1H2K2 →
Q31F72	—	0.993	Q31F72 →
Q9SS38	—	0.993	Q9SS38 →
A0L8B0	—	0.993	A0L8B0 →
Q60AK3	—	0.993	Q60AK3 →
A6V7J7	—	0.993	A6V7J7 →
Q2SKD0	—	0.993	Q2SKD0 →
Q7NYF6	—	0.993	Q7NYF6 →
Q39SQ3	—	0.993	Q39SQ3 →
Q62ID1	—	0.993	Q62ID1 →