UBE2V1

Ubiquitin-conjugating enzyme E2 variant 1 · Q13404 · UBE2V1 on Sugi Atlas →

15 patent compounds predicted against UBE2V1, 4 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Ophirapstanol Trisulfate Ophirapstanol Trisulfate (SCHEMBL31261405) 0.54 2/20
SCHEMBL29701326 SCHEMBL29701326 0.49 2/20
SCHEMBL17481168 SCHEMBL17481168 0.43 1/20
SCHEMBL19293417 SCHEMBL19293417 0.43 1/20

Clinical trials — most relevant to UBE2V1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma PHASE2WITHDRAWN
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma PHASE2SUSPENDED
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome PHASE2RECRUITING
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS) PHASE1COMPLETED
Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2 nanRECRUITING
Endocrine Disruptors and Life STILe in Breast Cancer Development nanUNKNOWN
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome nanRECRUITING
Genetics of Prostate Cancer in Young Patients nanCOMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS nanRECRUITING
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1 nanRECRUITING
HRQoL and Financial Toxicity in Patients With VEXAS Syndrome nanRECRUITING
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2 nanUNKNOWN
Phenotypic and Genotypic Characterization of Subjects With Syndromic Obesity: Identifying New Candidate Genes by Exome Sequencing (OBEXOME) nanCOMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome nanRECRUITING
COsegregation of VARiants in Panel of Genes nanRECRUITING
Pure Florid and Pleomorphic Lobular Carcinoma in Situ of the Breast: Towards an Increasingly Uniform Management nanCOMPLETED
Impact of Different BRCA1/2 Gene Variants on Response to Therapy and Prognosis of Ovarian Cancer nanRECRUITING
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC) nanUNKNOWN
Delineation of Novel Monogenic Disorders in the United Arab Emirates Population nanUNKNOWN
A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity nanRECRUITING
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia nanRECRUITING
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants nanRECRUITING
Clinical Utility of Pediatric Whole Exome Sequencing nanCOMPLETED
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk nanNOT_YET_RECRUITING
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts nanCOMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature. nanUNKNOWN
Uncertain Genetic Test Results for Lynch Syndrome nanCOMPLETED
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study nanACTIVE_NOT_RECRUITING
Genomic Predictors of Recurrent Pregnancy Loss nanRECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a UBE2V1 binder may also engage these)

ProteinNameSimilarity
Q5R4Z6 1.000 Q5R4Z6 →
Q3SZ52 1.000 Q3SZ52 →
Q7M767 1.000 Q7M767 →
Q9CZY3 1.000 Q9CZY3 →
Q5R6C9 1.000 Q5R6C9 →
Q6PEH5 1.000 Q6PEH5 →
Q90879 0.998 Q90879 →
Q15819 0.997 Q15819 →
Q3SZ43 0.997 Q3SZ43 →
Q9D2M8 0.997 Q9D2M8 →
Q9SVD7 0.996 Q9SVD7 →
Q7ZYP0 0.995 Q7ZYP0 →
Q5F3Z3 0.994 Q5F3Z3 →
Q9CAB6 0.992 Q9CAB6 →
O45495 0.990 O45495 →
Q93YP0 0.986 Q93YP0 →
Q9SJ44 0.984 Q9SJ44 →
O74983 0.977 O74983 →
Q54D06 0.974 Q54D06 →
P53152 0.971 P53152 →
Q9FMM0 0.967 Q9FMM0 →
O23239 0.967 O23239 →
Q9XWF6 0.966 Q9XWF6 →
P42743 0.964 P42743 →
Q55EY8 0.961 Q55EY8 →
Q4VBH4 0.960 Q4VBH4 →
Q6PCF7 0.960 Q6PCF7 →
Q6P8D9 0.959 Q6P8D9 →
Q9FWT2 0.958 Q9FWT2 →
A3KN22 0.958 A3KN22 →