ULK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL142543	0.56	8/20
SCHEMBL98692	0.92	2/20
SCHEMBL141930	0.90	2/20
SCHEMBL142206	0.85	2/20
SCHEMBL144842	0.80	2/20
SCHEMBL100845	0.80	2/20
SCHEMBL100309	0.77	2/20
SCHEMBL144192	0.75	2/20
SCHEMBL101864	0.74	2/20
SCHEMBL101702	0.71	2/20
SCHEMBL99685	0.71	2/20
SCHEMBL144525	0.71	2/20
SCHEMBL100966	0.70	2/20
SCHEMBL101072	0.70	2/20
SCHEMBL101686	0.70	2/20
SCHEMBL141676	0.69	2/20
SCHEMBL103295	0.68	2/20
SCHEMBL144281	0.68	2/20
SCHEMBL141372	0.68	2/20
SCHEMBL144785	0.67	2/20

Clinical trials — most relevant to ULK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)	PHASE4	RECRUITING
A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas	PHASE2	SUSPENDED
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer	PHASE2	COMPLETED
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma	PHASE1/PHASE2	COMPLETED
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients	PHASE2	UNKNOWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Epacadostat (INCB24360) in Combination With Sirolimus in Advanced Malignancy	PHASE1	UNKNOWN
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
The Role of Fibroblast Activation in Uterine Fibroid	nan	COMPLETED
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
Time Course for Fasting-induced Autophagy in Humans	nan	WITHDRAWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
The Impact of Intermittent Fasting on Human Metabolism and Cell Autophagy	nan	COMPLETED
Autophagy Bladder Cancer	nan	UNKNOWN
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy	nan	RECRUITING
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
The Effects of Whey vs. Collagen on MPS	nan	COMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
mTORC1 and Autophagy in Human Brown Adipocytes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ULK1 binder may also engage these)

Protein	Name	Similarity
O70405	—	1.000	O70405 →
NR4A1	Nuclear receptor subfamily 4immunitygroup A member 1	0.996	landscape →
Q3UJB9	—	0.995	Q3UJB9 →
Q80UE6	—	0.995	Q80UE6 →
Q5R8Z4	—	0.994	Q5R8Z4 →
P0C0T2	—	0.994	P0C0T2 →
Q498M5	—	0.993	Q498M5 →
Q96J92	—	0.993	Q96J92 →
A7E305	—	0.993	A7E305 →
Q7TPK6	—	0.993	Q7TPK6 →
Q80XS6	—	0.993	Q80XS6 →
Q3U1V8	—	0.992	Q3U1V8 →
Q60610	—	0.992	Q60610 →
Q8VDG6	—	0.992	Q8VDG6 →
Q61501	—	0.992	Q61501 →
Q5DTT2	—	0.992	Q5DTT2 →
Q7TN02	—	0.992	Q7TN02 →
Q9Y6A5	—	0.992	Q9Y6A5 →
E9Q9W7	—	0.992	E9Q9W7 →
E1BE02	—	0.992	E1BE02 →
D3ZG83	—	0.992	D3ZG83 →
Q68DC2	—	0.992	Q68DC2 →
Q8BLR5	—	0.992	Q8BLR5 →
P22829	—	0.992	P22829 →
Q3UIZ8	—	0.992	Q3UIZ8 →
Q9H5P4	—	0.992	Q9H5P4 →
MIDEAS	Mitotic deacetylase-associated SANT domain protein	0.991	landscape →
Q8K3T3	—	0.991	Q8K3T3 →
Q9WVS8	—	0.991	Q9WVS8 →
O08774	—	0.991	O08774 →