Sugi Predict

Sugi Predict / Targets / VPS35

VPS35

Vacuolar protein sorting-associated protein 35 · Q96QK1 · VPS35 on Sugi Atlas →

16 patent compounds predicted against VPS35, 3 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL16824748 SCHEMBL16824748 0.41 1/20
SCHEMBL3357410 SCHEMBL3357410 0.40 1/20
SCHEMBL12790876 SCHEMBL12790876 0.40 1/20

Clinical trials — most relevant to VPS35 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients PHASE2COMPLETED
Nilotinib in Huntington's Disease PHASE1UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Parkinson's Foundation PD GENEration Genetic Registry nanRECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease nanUNKNOWN
Natural History Study of Patients With VCP-related Disease nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
The Role of DNA and RNA in NGS Analyses for Advaced Stage NSCLC Patients nanRECRUITING
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
The Natural History of Alpha-Mannosidosis nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Biomarker Research in Inherited Movement Disorders nanRECRUITING
A Natural History Study of Neuronal Ceroid Lipofuscinosis Type 5 (CLN5) nanCOMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism nanCOMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients nanUNKNOWN
Time Course for Fasting-induced Autophagy in Humans nanWITHDRAWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts nanCOMPLETED
Evaluation of Serum Autophagic Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Individuals nanENROLLING_BY_INVITATION
Fasting, Exercise, and Diet to Activate Autophagy in Depression nanNOT_YET_RECRUITING
Study of Chediak-Higashi Syndrome nanRECRUITING
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer nanUNKNOWN
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Registry and Natural History of Epilepsy-Dyskinesia Syndromes nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a VPS35 binder may also engage these)

ProteinNameSimilarity
Q9EQH3 — 1.000 Q9EQH3 →
Q2HJG5 — 1.000 Q2HJG5 →
Q29G21 — 0.986 Q29G21 →
F4I0P8 — 0.984 F4I0P8 →
P45437 — 0.984 P45437 →
C0H906 — 0.984 C0H906 →
B4Q034 — 0.984 B4Q034 →
B3NU52 — 0.984 B3NU52 →
B4I0W6 — 0.983 B4I0W6 →
A7RWP6 — 0.983 A7RWP6 →
Q7PX35 — 0.982 Q7PX35 →
Q6DDM4 — 0.982 Q6DDM4 →
Q6GQD0 — 0.982 Q6GQD0 →
Q6GQ80 — 0.981 Q6GQ80 →
B3MS75 — 0.981 B3MS75 →
B4GW22 — 0.980 B4GW22 →
Q29G82 — 0.980 Q29G82 →
A1L1F4 — 0.980 A1L1F4 →
Q7X659 — 0.980 Q7X659 →
A0A0R4ITC5 — 0.980 A0A0R4ITC5 →
TRRAP Transformation/transcription domain-associated protein 0.980 landscape →
Q9D3E6 — 0.980 Q9D3E6 →
Q8WVM7 — 0.980 Q8WVM7 →
Q66HC5 — 0.979 Q66HC5 →
PDS5A Sister chromatid cohesion protein PDS5 homolog A 0.979 landscape →
Q9DGN0 — 0.979 Q9DGN0 →
Q7ZY79 — 0.979 Q7ZY79 →
Q6A026 — 0.979 Q6A026 →
Q498H0 — 0.979 Q498H0 →
O35638 — 0.979 O35638 →