WARS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to WARS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease	PHASE2	UNKNOWN
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress	nan	WITHDRAWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Quantifying Disease Progression in LBSL	nan	UNKNOWN
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Molecular and Clinical Studies of Primary Immunodeficiency Diseases	nan	UNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
I-Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Genomic of CONgenital Sideroblastic Anemias	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a WARS1 binder may also engage these)

Protein	Name	Similarity
Q5R4J1	—	1.000	Q5R4J1 →
P17248	—	1.000	P17248 →
P23612	—	1.000	P23612 →
P32921	—	0.998	P32921 →
Q12109	—	0.997	Q12109 →
Q6P7B0	—	0.996	Q6P7B0 →
Q9SR15	—	0.995	Q9SR15 →
Q55DZ8	—	0.994	Q55DZ8 →
Q6PBS3	—	0.994	Q6PBS3 →
Q09692	—	0.991	Q09692 →
Q23670	—	0.986	Q23670 →
O34764	—	0.985	O34764 →
Q27128	—	0.985	Q27128 →
O42130	—	0.984	O42130 →
Q4ULZ0	—	0.984	Q4ULZ0 →
Q99XH4	—	0.984	Q99XH4 →
Q9Y7Y8	—	0.984	Q9Y7Y8 →
P74241	—	0.984	P74241 →
Q0CLK1	—	0.984	Q0CLK1 →
Q60967	—	0.984	Q60967 →
B7HHH7	—	0.983	B7HHH7 →
B0T2A6	—	0.983	B0T2A6 →
O16140	—	0.982	O16140 →
P0DG60	—	0.982	P0DG60 →
Q976M1	—	0.982	Q976M1 →
A9VLJ0	—	0.982	A9VLJ0 →
Q9WVK4	—	0.982	Q9WVK4 →
Q91V92	—	0.981	Q91V92 →
Q5E9R3	—	0.981	Q5E9R3 →
Q86ZF1	—	0.981	Q86ZF1 →