WFS1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to WFS1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome	PHASE2	UNKNOWN
Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss	PHASE1/PHASE2	COMPLETED
Looking for VUS to Confirm Dominant Wolfram-like Syndrome Instead of Recessive Wolfram Syndrome	nan	ACTIVE_NOT_RECRUITING
I-Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Tracking Neurodegeneration in Early Wolfram Syndrome	nan	COMPLETED
Does Recessive Optic Atrophy Due to WFS1 Exist?	nan	NOT_YET_RECRUITING
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)	nan	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank	nan	COMPLETED
Mutation Exploration in Non-acquired, Genetic Disorders and Its Impact on Health Economy and Life Quality	nan	COMPLETED
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Development and Clinical Application of Two New Genetic Deafness Gene Diagnostic Kit	nan	UNKNOWN
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets	nan	RECRUITING
Development of an Optimal Approach to Return of Results for Next-generation Sequencing for Prenatal Diagnosis	nan	WITHDRAWN
Clinical Utility of Pediatric Whole Exome Sequencing	nan	COMPLETED
Impact of Elastin Mediated Vascular Stiffness on End Organs	nan	COMPLETED
Genetic Analysis of Fraser Syndrome and Fryns Syndrome	nan	COMPLETED
Rapid Whole Genome Sequencing Study	nan	ENROLLING_BY_INVITATION
Long-term Renal Prognosis of Neonatal Acute Kidney Injury	nan	NOT_YET_RECRUITING
Clinical Utility of Prenatal Whole Exome Sequencing	nan	COMPLETED
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Uncovering the Etiologies of Non-immune Hydrops Fetalis	nan	ENROLLING_BY_INVITATION
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Genomic Profiling of Genetic and Rare Diseases	nan	RECRUITING
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a WFS1 binder may also engage these)

Protein	Name	Similarity
P56695	—	1.000	P56695 →
O88480	—	0.993	O88480 →
Q6DF19	—	0.993	Q6DF19 →
Q4VBG5	—	0.993	Q4VBG5 →
Q5ZLS8	—	0.991	Q5ZLS8 →
Q91ZD4	—	0.991	Q91ZD4 →
Q8TAA9	—	0.990	Q8TAA9 →
Q66H44	—	0.990	Q66H44 →
Q3UHQ6	—	0.990	Q3UHQ6 →
B4N5D3	—	0.990	B4N5D3 →
Q91VB4	—	0.990	Q91VB4 →
B4J2W3	—	0.989	B4J2W3 →
A1A4J7	—	0.989	A1A4J7 →
Q96HH4	—	0.989	Q96HH4 →
B4LC58	—	0.988	B4LC58 →
PIK3C2B	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0.988	landscape →
Q62141	—	0.988	Q62141 →
Q99K74	—	0.988	Q99K74 →
Q6NRB7	—	0.988	Q6NRB7 →
Q9P2D8	—	0.988	Q9P2D8 →
Q6AX31	—	0.988	Q6AX31 →
Q91YN0	—	0.988	Q91YN0 →
F1QN74	—	0.988	F1QN74 →
Q9WU61	—	0.988	Q9WU61 →
B4PF15	—	0.988	B4PF15 →
Q8R4Z9	—	0.988	Q8R4Z9 →
BRI3BP	BRI3-binding protein	0.988	landscape →
Q5F3M0	—	0.988	Q5F3M0 →
A2BID5	—	0.988	A2BID5 →
Q99ML0	—	0.988	Q99ML0 →