AIP c.(?_1
Likely pathogenic
No assertion criteria
Classification
Likely pathogenic
ClinVar
Review
No assertion criteria ☆☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
Conditions
1
growth hormone secreting pituitary adenoma 1
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type. |
Variant & gene context
- Gene
- AIP
- Coding
- c.(?_1
- MANE Select
- NM_017900 · reported on NM_003977
- Type
- Deletion
- Structure
- AlphaFold pLDDT 70.14 · 81 PDB
Disease context
growth hormone secreting pituitary adenoma 1 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatmentsFor Familial isolated pituitary adenoma (Orphanet):
- Inheritance
- Autosomal dominant
- Onset
- Adolescent, Adult, Childhood, Elderly, Infancy
Similar variants
- AIP p.Pro167_Trp168insTer Pathogenic/Likely pathogenic ★★ same condition
- AIP p.Gly47_Arg54del Uncertain significance ★★ same condition
- AIP p.Val101_Leu141del Likely pathogenic ★ same condition
- AIP c.100-1025_279+357del Likely pathogenic same condition
- AIP p.Gly23_Glu24del Pathogenic same condition
- AIP p.Ile182fs Pathogenic same condition
- AIP p.Arg271Trp Pathogenic/Likely pathogenic ★★ same condition
- AIP p.Arg304Ter Pathogenic ★★ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/aip-c-1 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown