Is ALK p.Pro36Leu (c.107C>T) pathogenic?

ALK p.Pro36Leu (c.107C>T) is classified Conflicting classifications of pathogenicity in ALK (ClinVar, Conflicting submitters, 4 submitters; last evaluated 2025-11-19). AlphaMissense: likely benign (0.0601); Very rare (popmax 0.00168%, amr); Associated with ALK-related disorder.

What condition is associated with ALK p.Pro36Leu (c.107C>T)?

ALK p.Pro36Leu (c.107C>T) is associated with ALK-related disorder, neuroblastoma, susceptibility to, 3, hereditary neoplastic syndrome (ClinVar).

How common is ALK p.Pro36Leu (c.107C>T) in the general population?

ALK p.Pro36Leu (c.107C>T) is very rare (popmax 0.00168%, amr) (gnomAD).

What do computational predictors say about ALK p.Pro36Leu (c.107C>T)?

AlphaMissense predicts likely benign (score 0.0601) — an in-silico prediction, not a clinical call.

ALK p.Pro36Leu

c.107C>T · rs773691688 · VCV470733

Conflicting classifications of pathogenicity Conflicting submitters

Classification

Conflicting classifications of pathogenicity

ClinVar

Review

Conflicting submitters ★☆☆☆

ClinVar · 4 submitters

AlphaMissense

likely benign

0.0601 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00168%, amr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

ALK-related disorder

Computational evidence

Protein change
AlphaMissense	0.0601	likely benign
REVEL	0.022	moderately benign-leaning
SaProt	LLR -6.91	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 1.5	GERP -1.2, phastCons 0.97
Regional constraint	o/e 1.05	unconstrained · MANE · 670 kb · p 0.12 · regional, not allelic
Overall
CADD	14.61	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00168% Admixed American · 1/59,596 alleles

Overall 0.000374% 6/1,603,824 alleles · very rare

Ancestry group	Frequency	1 in
Remaining individualsnot grpmax-eligible	0.00483%	20,692
Admixed Americangrpmax	0.00168%	59,596
African / African-American	0.00133%	74,942
South Asian	0.00111%	90,402

Remaining individuals shows a higher raw frequency than the grpmax group above it. gnomAD excludes bottlenecked groups — Finnish, Ashkenazi Jewish, Amish and “Remaining individuals” — from grpmax, because founder effects make their frequencies unrepresentative for filtering. The table is sorted by frequency, so an excluded group can sit above the grpmax row.

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: ALK
Protein: p.Pro36Leu
Coding: c.107C>T
MANE Select: NM_004304
dbSNP: rs773691688
Type: single nucleotide variant
Location: chr2:29920553 (GRCh38)
Gene constraint: LOEUF 0.562 · pLI <0.01 · ClinGen HI 0/3 (gnomAD)
Structure: AlphaFold pLDDT 68.26 · 79 PDB

Full ALK gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

ALK-related disorder

Also linked: neuroblastoma, susceptibility to, 3 hereditary neoplastic syndrome

Similar variants

ALK p.Pro36= Likely benign ★★ same residue
ALK p.Pro36Ser Benign/Likely benign ★★ same residue
ALK p.Pro36Arg Uncertain significance ★ ⚠ same residue
ALK p.Pro36Gln Conflicting classifications of pathogenicity ★ ⚠ same residue
ALK p.Pro36fs Uncertain significance ★ same residue
ALK p.Arg1275Gln Pathogenic ★★ same condition
ALK c.1154+5G>A Uncertain significance ★★ same condition
ALK c.1155-3C>T Uncertain significance ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/alk-p-pro36leu (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown