Is APC p.Ala614Val (c.1841C>T) pathogenic?

APC p.Ala614Val (c.1841C>T) is classified Uncertain significance in APC (ClinVar, Single submitter, 1 submitter; last evaluated 2025-12-01). AlphaMissense: likely benign (0.2204); Absent from gnomAD v4.1.

How common is APC p.Ala614Val (c.1841C>T) in the general population?

APC p.Ala614Val (c.1841C>T) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about APC p.Ala614Val (c.1841C>T)?

AlphaMissense predicts likely benign (score 0.2204) — an in-silico prediction, not a clinical call.

APC p.Ala614Val

c.1841C>T · VCV4681941

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.2204 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Computational evidence

Protein change
AlphaMissense	0.2204	likely benign
REVEL	0.379	indeterminate
SaProt	—	not scored · why
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 6	GERP 1.1, phastCons 1
Regional constraint	o/e 0.74	unconstrained · MANE · 11 kb · p 4.8e-05 · regional, not allelic
Overall
CADD	25.9	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL is an independent agreement signal.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: APC
Protein: p.Ala614Val
Coding: c.1841C>T
MANE Select: NM_000038
Type: single nucleotide variant
Location: chr5:112835048 (GRCh38)
Gene constraint: LOEUF 0.321 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Residue 614: an α-helix

Full APC gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

APC p.Ala614Gly Uncertain significance ★★ ⚠ same residue
APC p.Ala614= Benign/Likely benign ★★ same residue
APC p.Ala614Glu Uncertain significance ★ same residue
APC p.Ala614Thr Uncertain significance ★ same residue
APC p.Ala614fs Pathogenic ★ same residue
APC c.1312+3A>C Likely pathogenic ★★★ same type
APC c.1312+3A>G Pathogenic ★★★ same type
APC c.1312+5G>A Likely pathogenic ★★★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/apc-p-ala614val (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown