Is APC p.Pro2158= (c.6474C>G) pathogenic?

APC p.Pro2158= (c.6474C>G) is classified Benign/Likely benign in APC (ClinVar, Multiple submitters, 3 submitters; last evaluated 2025-11-22). Very rare (popmax 0.00534%, afr); Associated with hereditary neoplastic syndrome.

What condition is associated with APC p.Pro2158= (c.6474C>G)?

APC p.Pro2158= (c.6474C>G) is associated with hereditary neoplastic syndrome, familial adenomatous polyposis 1 (ClinVar).

How common is APC p.Pro2158= (c.6474C>G) in the general population?

APC p.Pro2158= (c.6474C>G) is very rare (popmax 0.00534%, afr) (gnomAD).

APC p.Pro2158=

c.6474C>G · rs772027192 · VCV186613

Benign/Likely benign Multiple submitters

Classification

Benign/Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 3 submitters

gnomAD v4.1

Rare

very rare (popmax 0.00534%, afr)

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -0.055	GERP -1.6, phastCons 0.54
Overall
CADD	4.34	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00534% African / African-American · 4/74,846 alleles

Filtering AF 0.00175% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00104%

Overall 0.000372% 6/1,612,310 alleles · very rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.00534%	18,711
Admixed American	0.00167%	59,976
European (non-Finnish)	8.48e-05%	1,178,574

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: APC
Protein: p.Pro2158=
Coding: c.6474C>G
MANE Select: NM_000038
dbSNP: rs772027192
Type: single nucleotide variant
Location: chr5:112842068 (GRCh38)
Gene constraint: LOEUF 0.321 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Residue 2158: the 'disordered' region

Full APC gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: familial adenomatous polyposis 1

Similar variants

APC p.Pro2158Leu Uncertain significance ★★ same residue
APC p.Pro2158Arg Conflicting classifications of pathogenicity ★ ⚠ same residue
APC p.Pro2158His Conflicting classifications of pathogenicity ★ same residue
APC p.Pro2158Ser Uncertain significance ★ ⚠ same residue
APC p.Pro2158Thr Uncertain significance ★ ⚠ same residue
APC c.1312+3A>C Likely pathogenic ★★★ same condition
APC c.1312+3A>G Pathogenic ★★★ same condition
APC c.1312+5G>A Likely pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/apc-p-pro2158 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown