Is APC p.Ser905Arg (c.2715T>A) pathogenic?

APC p.Ser905Arg (c.2715T>A) is classified Uncertain significance in APC (ClinVar, Single submitter, 1 submitter; last evaluated 2023-02-03). AlphaMissense: ambiguous (0.4013); Absent from gnomAD v4.1; Associated with hereditary neoplastic syndrome.

What condition is associated with APC p.Ser905Arg (c.2715T>A)?

APC p.Ser905Arg (c.2715T>A) is associated with hereditary neoplastic syndrome (ClinVar).

How common is APC p.Ser905Arg (c.2715T>A) in the general population?

APC p.Ser905Arg (c.2715T>A) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about APC p.Ser905Arg (c.2715T>A)?

AlphaMissense predicts ambiguous (score 0.4013) — an in-silico prediction, not a clinical call.

APC p.Ser905Arg

c.2715T>A · rs2149875887 · VCV2452720

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

ambiguous

0.4013 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
AlphaMissense	0.4013	ambiguous
REVEL	0.419	indeterminate
SaProt	—	not scored · why
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 2	GERP -2, phastCons 1
Regional constraint	o/e 1.09	unconstrained · MANE · 1,681 bp · p 0.023 · regional, not allelic
Overall
CADD	16.84	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL is an independent agreement signal.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: APC
Protein: p.Ser905Arg
Coding: c.2715T>A
MANE Select: NM_000038
dbSNP: rs2149875887
Type: single nucleotide variant
Location: chr5:112838309 (GRCh38)
Gene constraint: LOEUF 0.321 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)

Full APC gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

APC p.Ser905Asn Uncertain significance ★★ same residue
APC p.Ser905Ile Uncertain significance ★★ same residue
APC p.Ser905Thr Uncertain significance ★★ same residue
APC p.Ser905= Benign ★ same residue
APC c.1312+3A>C Likely pathogenic ★★★ same condition
APC c.1312+3A>G Pathogenic ★★★ same condition
APC c.1312+5G>A Likely pathogenic ★★★ same condition
APC c.1312+5G>C Likely pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/apc-p-ser905arg (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown