Is BRCA1 p.Ser1577Pro (c.4729T>C) pathogenic?

BRCA1 p.Ser1577Pro (c.4729T>C) is classified Benign/Likely benign in BRCA1 (ClinVar, Multiple submitters, 14 submitters; last evaluated 2026-02-03). AlphaMissense: likely benign (0.1243); Rare (popmax 0.294%, eas); Associated with hereditary neoplastic syndrome.

What condition is associated with BRCA1 p.Ser1577Pro (c.4729T>C)?

BRCA1 p.Ser1577Pro (c.4729T>C) is associated with hereditary neoplastic syndrome, hereditary breast ovarian cancer syndrome, breast-ovarian cancer, familial, susceptibility to, 1 (ClinVar).

How common is BRCA1 p.Ser1577Pro (c.4729T>C) in the general population?

BRCA1 p.Ser1577Pro (c.4729T>C) is rare (popmax 0.294%, eas) (gnomAD).

What do computational predictors say about BRCA1 p.Ser1577Pro (c.4729T>C)?

AlphaMissense predicts likely benign (score 0.1243) — an in-silico prediction, not a clinical call.

BRCA1 p.Ser1577Pro

c.4729T>C · rs80356909 · VCV55272

Benign/Likely benign Multiple submitters

Classification

Benign/Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 14 submitters

AlphaMissense

likely benign

0.1243 · ACMG-weighted

gnomAD v4.1

Rare

rare (popmax 0.294%, eas)

Missense predictors

0/2 damaging

AlphaMissense, SaProt · REVEL no call

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
AlphaMissense	0.1243	likely benign
REVEL	0.559	indeterminate
SaProt	LLR -6.47	tolerated
⇒ AlphaMissense and SaProt both call this tolerated; REVEL makes no call.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 4.3	GERP -2.1, phastCons 0.96
Regional constraint	o/e 0.91	unconstrained · MANE · 78 kb · p 4.8e-05 · regional, not allelic
Overall
CADD	13.71	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.294% East Asian · 132/44,898 alleles

Filtering AF 0.253% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.238%

Overall 0.0083% 134/1,614,110 alleles · rare

Ancestry group	Frequency	1 in
East Asiangrpmax	0.294%	340
Admixed American	0.00167%	60,002
Remaining individualsnot grpmax-eligible	0.0016%	62,490

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: BRCA1
Protein: p.Ser1577Pro
Coding: c.4729T>C
MANE Select: NM_007294
dbSNP: rs80356909
Type: single nucleotide variant
Location: chr17:43071185 (GRCh38)
Gene constraint: LOEUF 0.885 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 41.99 · 33 PDB
Residue 1577: the 'disordered' region; a UniProt-annotated variant site (in fancs)

Full BRCA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary breast ovarian cancer syndrome breast-ovarian cancer, familial, susceptibility to, 1 Fanconi anemia, complementation group S

Similar variants

BRCA1 p.Ser1577Phe Uncertain significance ★★ ⚠ same residue
BRCA1 p.Ser1577= Likely benign ★★ same residue
BRCA1 p.Ser1577Tyr Conflicting classifications of pathogenicity ★ ⚠ same residue
BRCA1 p.Ser1577fs Pathogenic ★ same residue
BRCA1 p.Ser1577Ala Uncertain significance ★ ⚠ same residue
BRCA1 c.134+3A>T Likely pathogenic ★★★ same condition
BRCA1 c.135-1G>T Pathogenic ★★★ same condition
BRCA1 c.212+1G>A Pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/brca1-p-ser1577pro (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown