Is BRCA2 p.Glu297= (c.891A>G) pathogenic?

BRCA2 p.Glu297= (c.891A>G) is classified Likely benign in BRCA2 (ClinVar, Multiple submitters, 3 submitters; last evaluated 2025-11-01). Very rare (popmax 0.00114%, sas); Associated with hereditary neoplastic syndrome.

What condition is associated with BRCA2 p.Glu297= (c.891A>G)?

BRCA2 p.Glu297= (c.891A>G) is associated with hereditary neoplastic syndrome, hereditary breast ovarian cancer syndrome (ClinVar).

How common is BRCA2 p.Glu297= (c.891A>G) in the general population?

BRCA2 p.Glu297= (c.891A>G) is very rare (popmax 0.00114%, sas) (gnomAD).

BRCA2 p.Glu297=

c.891A>G · rs2137465559 · VCV1765099

Likely benign Multiple submitters

Classification

Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 3 submitters

gnomAD v4.1

Rare

very rare (popmax 0.00114%, sas)

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	<0.2	no splice effect predicted · four deltas, not one · how we know
Constraint at this position
Conservation	phyloP 2.7	GERP -1.5, phastCons 0.96
Overall
CADD	0.931	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00114% South Asian · 1/87,624 alleles

Filtering AF 0.000125% ClinGen BA1/BS1 input FAF95, joint · FAF99 9.1e-05%

Overall 0.000376% 6/1,596,792 alleles · very rare exomes 6/1,444,462 · genomes 0/152,330 · joint denominator

Ancestry group	Frequency	1 in
South Asiangrpmax	0.00114%	87,624
European (non-Finnish)	0.000427%	234,201

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: BRCA2
Protein: p.Glu297=
Coding: c.891A>G
MANE Select: NM_000059
dbSNP: rs2137465559
Type: single nucleotide variant
Location: chr13:32332369 (GRCh38)
Gene constraint: LOEUF 0.803 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)

Full BRCA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary breast ovarian cancer syndrome

Similar variants

BRCA2 p.Glu297Ter Pathogenic ★★★ same residue
BRCA2 p.Glu297Gln Uncertain significance ★ ⚠ same residue
BRCA2 p.Glu297Gly Conflicting classifications of pathogenicity ★ ⚠ same residue
BRCA2 p.Glu297_Val300del Uncertain significance ★ same residue
BRCA2 c.316+1G>T Pathogenic ★★★ same condition
BRCA2 c.316+2T>C Pathogenic ★★★ same condition
BRCA2 c.316+5G>A Pathogenic ★★★ same condition
BRCA2 c.316+5G>C Pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/brca2-p-glu297 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown