Is BRCA2 p.Val2527= (c.7581A>G) pathogenic?

BRCA2 p.Val2527= (c.7581A>G) is classified Likely benign in BRCA2 (ClinVar, Multiple submitters, 4 submitters; last evaluated 2025-03-04). Absent from gnomAD v4.1; Associated with hereditary neoplastic syndrome.

What condition is associated with BRCA2 p.Val2527= (c.7581A>G)?

BRCA2 p.Val2527= (c.7581A>G) is associated with hereditary neoplastic syndrome, hereditary breast ovarian cancer syndrome (ClinVar).

How common is BRCA2 p.Val2527= (c.7581A>G) in the general population?

BRCA2 p.Val2527= (c.7581A>G) is absent from gnomAD v4.1 (gnomAD).

BRCA2 p.Val2527=

c.7581A>G · rs1409888455 · VCV827137

Likely benign Multiple submitters

Classification

Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 4 submitters

gnomAD v4.1

Absent

absent from gnomAD v4.1

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -0.41	GERP -4.6
Overall
CADD	3.34	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: BRCA2
Protein: p.Val2527=
Coding: c.7581A>G
MANE Select: NM_000059
dbSNP: rs1409888455
Type: single nucleotide variant
Location: chr13:32356573 (GRCh38)
Gene constraint: LOEUF 0.803 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Residue 2527: the 'interaction with fancd2' region; the 'interaction with sem1' region

Full BRCA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary breast ovarian cancer syndrome

Similar variants

BRCA2 p.Val2527Ala Conflicting classifications of pathogenicity ★ ⚠ same residue
BRCA2 p.Val2527Gly Uncertain significance ★ same residue
BRCA2 p.Val2527Ile Conflicting classifications of pathogenicity ★ same residue
BRCA2 p.Val2527Leu Conflicting classifications of pathogenicity ★ same residue
BRCA2 p.Val2527fs Pathogenic/Likely pathogenic ★★ same residue
BRCA2 p.Val2527del Uncertain significance ★ same residue
BRCA2 p.Val2527Glu Uncertain significance ★ ⚠ same residue
BRCA2 c.316+1G>T Pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/brca2-p-val2527 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown