Is C4B p.Arg844His (c.2531G>A) pathogenic?

C4B p.Arg844His (c.2531G>A) is classified Uncertain significance in C4B (ClinVar, Single submitter, 1 submitter; last evaluated 2025-01-23). AlphaMissense: likely benign (0.0664); Rare (popmax 0.19%, amr).

How common is C4B p.Arg844His (c.2531G>A) in the general population?

C4B p.Arg844His (c.2531G>A) is rare (popmax 0.19%, amr) (gnomAD).

What do computational predictors say about C4B p.Arg844His (c.2531G>A)?

AlphaMissense predicts likely benign (score 0.0664) — an in-silico prediction, not a clinical call.

C4B p.Arg844His

c.2531G>A · VCV3826361

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0664 · ACMG-weighted

gnomAD v4.1

Rare

rare (popmax 0.19%, amr)

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0664	likely benign
REVEL	0.04	moderately benign-leaning
SaProt	LLR -7.67	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 0.48	GERP -4, phastCons 0.98
Overall
CADD	17.13	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.19% Admixed American · 109/57,410 alleles

Filtering AF 0.161% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.15%

Overall 0.0276% 424/1,534,274 alleles · rare

Ancestry group	Frequency	1 in
Admixed Americangrpmax	0.19%	527
Middle Eastern	0.0351%	2,848
Remaining individualsnot grpmax-eligible	0.0317%	3,158
European (non-Finnish)	0.0254%	3,935
African / African-American	0.0096%	10,413
Finnishnot grpmax-eligible	0.00171%	58,332
South Asian	0.00114%	87,516

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: C4B
Protein: p.Arg844His
Coding: c.2531G>A
MANE Select: NM_007293 · reported on NM_001002029
Type: single nucleotide variant
Location: chr6:32027061 (GRCh38)
Structure: AlphaFold pLDDT 83.56 · 12 PDB

Full C4B gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

C4A c.2944+55T>C Benign/Likely benign ★★ same type
C4A p.Asp1073Gly Benign/Likely benign ★★ same type
C4A p.Pro1120Thr Likely benign ★★ same type
C4B p.Ser1176Asn Benign ★★ ⚠ same type
C4B p.Thr907Ala Benign/Likely benign ★★ same type
C4B c.3230+1G>A Likely pathogenic ★ same type
C4B c.3676+1G>A Likely pathogenic ★ same type
C4A p.Ala1062Val Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/c4b-p-arg844his (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown