Is C4B p.Arg845His (c.2534G>A) pathogenic?

C4B p.Arg845His (c.2534G>A) is classified Uncertain significance in C4B (ClinVar, Single submitter, 1 submitter; last evaluated 2025-08-24). AlphaMissense: likely benign (0.1391); Very rare (popmax 0.00342%, sas).

How common is C4B p.Arg845His (c.2534G>A) in the general population?

C4B p.Arg845His (c.2534G>A) is very rare (popmax 0.00342%, sas) (gnomAD).

What do computational predictors say about C4B p.Arg845His (c.2534G>A)?

AlphaMissense predicts likely benign (score 0.1391) — an in-silico prediction, not a clinical call.

C4B p.Arg845His

c.2534G>A · VCV4217375

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.1391 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00342%, sas)

Missense predictors

1/2 damaging

AlphaMissense, SaProt · REVEL no call

Computational evidence

Protein change
AlphaMissense	0.1391	likely benign
REVEL	0.376	indeterminate
SaProt	LLR -11.74	damaging
⇒ SaProt calls this damaging; AlphaMissense does not; REVEL makes no call.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 9.8	GERP 2, phastCons 1
Overall
CADD	31.0	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00342% South Asian · 3/87,738 alleles

Filtering AF 0.00136% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00114%

Overall 0.00176% 27/1,538,008 alleles · very rare

Ancestry group	Frequency	1 in
South Asiangrpmax	0.00342%	29,246
European (non-Finnish)	0.00205%	48,881
African / African-American	0.00137%	72,894

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: C4B
Protein: p.Arg845His
Coding: c.2534G>A
MANE Select: NM_007293 · reported on NM_001002029
Type: single nucleotide variant
Location: chr6:32027064 (GRCh38)
Structure: AlphaFold pLDDT 83.56 · 12 PDB

Full C4B gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

C4A c.2944+55T>C Benign/Likely benign ★★ same type
C4A p.Asp1073Gly Benign/Likely benign ★★ same type
C4A p.Pro1120Thr Likely benign ★★ same type
C4B p.Ser1176Asn Benign ★★ same type
C4B p.Thr907Ala Benign/Likely benign ★★ same type
C4B c.3230+1G>A Likely pathogenic ★ same type
C4B c.3676+1G>A Likely pathogenic ★ same type
C4A p.Ala1062Val Uncertain significance ★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/c4b-p-arg845his (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown