Is CDK8 p.Lys370Arg (c.1109A>G) pathogenic?

CDK8 p.Lys370Arg (c.1109A>G) is classified Uncertain significance in CDK8 (ClinVar, Single submitter, 1 submitter; last evaluated 2023-06-28). AlphaMissense: likely benign (0.0832); Absent from gnomAD v4.1.

How common is CDK8 p.Lys370Arg (c.1109A>G) in the general population?

CDK8 p.Lys370Arg (c.1109A>G) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about CDK8 p.Lys370Arg (c.1109A>G)?

AlphaMissense predicts likely benign (score 0.0832) — an in-silico prediction, not a clinical call.

CDK8 p.Lys370Arg

c.1109A>G · VCV3360647

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0832 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.0832	likely benign
REVEL	0.184	benign-leaning
SaProt	LLR -7.63	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 11	phastCons 1
Regional constraint	o/e 0.42	unconstrained · MANE · 16 kb · p 1.1e-18 · regional, not allelic
Overall
CADD	27.1	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: CDK8
Protein: p.Lys370Arg
Coding: c.1109A>G
MANE Select: NM_001260
Type: single nucleotide variant
Location: chr13:26401346 (GRCh38)
Gene constraint: LOEUF 0.646 · pLI 0.47 (gnomAD)
Structure: AlphaFold pLDDT 80.75 · 36 PDB
Residue 370: the 'disordered' region

Full CDK8 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

CDK8 p.Ser62Leu Pathogenic ★★ same type
CDK8 p.Asn433Lys Uncertain significance ★★ ⚠ same type
CDK8 p.Met445Ile Uncertain significance ★★ ⚠ same type
CDK8 p.Pro388Gln Uncertain significance ★★ ⚠ same type
CDK8 c.934-28G>A Benign ★★ same type
CDK8 p.Ala188Gly Likely pathogenic ★ same type
CDK8 p.Arg178Gln Pathogenic ★ same type
CDK8 p.Asn156Ser Pathogenic ★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/cdk8-p-lys370arg (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown