Is DBT p.Asn361fs (c.1082dup) pathogenic?

DBT p.Asn361fs (c.1082dup) is classified Pathogenic in DBT (ClinVar, Single submitter, 1 submitter; last evaluated 2019-05-28). Absent from gnomAD; Associated with maple syrup urine disease.

What condition is associated with DBT p.Asn361fs (c.1082dup)?

DBT p.Asn361fs (c.1082dup) is associated with maple syrup urine disease (ClinVar).

How common is DBT p.Asn361fs (c.1082dup) in the general population?

DBT p.Asn361fs (c.1082dup) is absent from gnomAD (gnomAD).

How is Maple syrup urine disease inherited?

Typically Autosomal recessive (Orphanet). A genetic counselor can assess individual risk for a family.

DBT p.Asn361fs

c.1082dup · rs1570806631 · VCV801528

Pathogenic Single submitter

Classification

Pathogenic

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

Consequence

frameshift

predicted LoF

gnomAD v4.1

Not reported

no gnomAD frequency available for this variant

Conditions

maple syrup urine disease

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Consequence	frameshift	predicted loss-of-function
NMD	predicted	premature termination codon in exon 9 of 11
Splicing
SpliceAI	—	not assessed · substitutions only
Constraint at this position
Conservation	phyloP -3.3	GERP -3.6

Predicted loss-of-function is descriptive, not an applied PVS1 code.

Population frequency

dbSNP / gnomAD

No gnomAD frequency available for this variant. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.

Variant & gene context

Gene: DBT
Protein: p.Asn361fs
Coding: c.1082dup
MANE Select: NM_001918
dbSNP: rs1570806631
Type: Duplication
Location: chr1:100206571 (GRCh38)
Gene constraint: LOEUF 1.255 · pLI <0.01 · ClinGen HI gene assoc. with recessive phenotype (gnomAD)
Structure: AlphaFold pLDDT 78.71 · 5 PDB

Full DBT gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

maple syrup urine disease — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For Maple syrup urine disease (Orphanet):

Inheritance: Autosomal recessive
Onset: Childhood, Infancy, Neonatal
Prevalence: 1-9 / 1 000 000 (Worldwide)

Similar variants

DBT p.His49fs Pathogenic/Likely pathogenic ★★ same condition
DBT p.Asn28dup Uncertain significance ★★ same condition
DBT c.1282-24_1282-10dup Benign/Likely benign ★★ same condition
DBT c.251+19dup Benign/Likely benign ★★ same condition
DBT p.Ala422fs Pathogenic ★ same condition
DBT p.Ile186fs Pathogenic ★ same condition
DBT p.Leu217fs Pathogenic ★ same condition
DBT p.Met6fs Pathogenic ★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/dbt-p-asn361fs (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown