FIGLA c.+5T>A
Benign
Single submitter
Classification
Benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type. |
Variant & gene context
- Gene
- FIGLA
- Coding
- c.+5T>A
- MANE Select
- NM_001004311
- Type
- single nucleotide variant
- Gene constraint
- LOEUF 1.279 · pLI <0.01 (gnomAD)
- Structure
- AlphaFold pLDDT 71.67
Similar variants
- FIGLA p.Ala4Glu Uncertain significance ★★ ⚠ same type
- FIGLA p.Pro10His Uncertain significance ★★ ⚠ same type
- FIGLA p.Pro10Ser Uncertain significance ★★ ⚠ same type
- FIGLA p.Thr200Ile Uncertain significance ★★ ⚠ same type
- FIGLA p.Val25Met Uncertain significance ★★ ⚠ same type
- FIGLA c.231+24T>C Benign ★★ same type
- FIGLA c.384+55A>G Benign ★★ same type
- FIGLA c.610-175G>A Likely benign ★★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/figla-c-plus-5t-a (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown