A1BG — 83 ClinVar variants
All ClinVar germline A1BG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
2 Likely benign · 81 Uncertain significance
Full A1BG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- A1BG p.Ala295Val Uncertain significance Single submitter
- A1BG p.Ala327Gly Uncertain significance Single submitter
- A1BG p.Ala51Gly Uncertain significance Single submitter
- A1BG p.Arg144Gln Uncertain significance Single submitter
- A1BG p.Arg90His Uncertain significance Single submitter
- A1BG p.Arg92His Uncertain significance Single submitter
- A1BG p.Asp155Glu Uncertain significance Single submitter
- A1BG p.Asp293Asn Uncertain significance Single submitter
- A1BG p.Asp340Glu Uncertain significance Single submitter
- A1BG p.Asp378Glu Uncertain significance Single submitter
- A1BG p.Cys232Ser Uncertain significance Single submitter
- A1BG p.Cys232Trp Uncertain significance Single submitter
- A1BG p.Gln176His Uncertain significance Single submitter
- A1BG p.Glu330Lys Uncertain significance Single submitter
- A1BG p.Glu439Asp Uncertain significance Single submitter
- A1BG p.Glu68Asp Uncertain significance Single submitter
- A1BG p.Gly318Ser Uncertain significance Single submitter
- A1BG p.Gly96Val Uncertain significance Single submitter
- A1BG p.His52Pro Uncertain significance Single submitter
- A1BG p.Leu116Phe Uncertain significance Single submitter
- A1BG p.Leu133Val Uncertain significance Single submitter
- A1BG p.Leu192Arg Uncertain significance Single submitter
- A1BG p.Lys248Gln Uncertain significance Single submitter
- A1BG p.Met3Ile Uncertain significance Single submitter
- A1BG p.Pro235Thr Uncertain significance Single submitter
- A1BG p.Pro313Leu Uncertain significance Single submitter
- A1BG p.Pro426Ala Uncertain significance Single submitter
- A1BG p.Pro426Ser Uncertain significance Single submitter
- A1BG p.Pro449Ala Uncertain significance Single submitter
- A1BG p.Ser258Thr Uncertain significance Single submitter
- A1BG p.Ser317Thr Uncertain significance Single submitter
- A1BG p.Thr102Ser Uncertain significance Single submitter
- A1BG p.Thr87Ile Uncertain significance Single submitter
- A1BG p.Val375Ile Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- A1BG p.Ala170Thr Uncertain significance Single submitter
- A1BG p.Ala197Thr Uncertain significance Single submitter
- A1BG p.Ala308Glu Uncertain significance Single submitter
- A1BG p.Ala308Thr Uncertain significance Single submitter
- A1BG p.Ala335Thr Uncertain significance Single submitter
- A1BG p.Ala357Glu Uncertain significance Single submitter
- A1BG p.Ala357Thr Uncertain significance Single submitter
- A1BG p.Arg152Gln Uncertain significance Single submitter
- A1BG p.Arg152Trp Uncertain significance Single submitter
- A1BG p.Arg245His Uncertain significance Single submitter
- A1BG p.Arg254Gly Uncertain significance Single submitter
- A1BG p.Arg280Cys Uncertain significance Single submitter
- A1BG p.Arg280His Uncertain significance Single submitter
- A1BG p.Arg333Pro Uncertain significance Single submitter
- A1BG p.Arg406Gln Uncertain significance Single submitter
- A1BG p.Arg447Cys Uncertain significance Single submitter
- A1BG p.Arg473Gly Uncertain significance Single submitter
- A1BG p.Arg90Cys Uncertain significance Single submitter
- A1BG p.Asp155Asn Uncertain significance Single submitter
- A1BG p.Asp240Asn Uncertain significance Single submitter
- A1BG p.Asp273Gly Uncertain significance Single submitter
- A1BG p.Asp303Asn Uncertain significance Single submitter
- A1BG p.Glu160Asp Uncertain significance Single submitter
- A1BG p.Glu356Lys Uncertain significance Single submitter
- A1BG p.Glu437Asp Uncertain significance Single submitter
- A1BG p.Glu489Gln Uncertain significance Single submitter
- A1BG p.Gly132Arg Uncertain significance Single submitter
- A1BG p.Gly246Arg Uncertain significance Single submitter
- A1BG p.Gly331Cys Uncertain significance Single submitter
- A1BG p.Leu336Arg Uncertain significance Single submitter
- A1BG p.Leu435Pro Uncertain significance Single submitter
- A1BG p.Leu83Gln Uncertain significance Single submitter
- A1BG p.Phe172Ser Uncertain significance Single submitter
- A1BG p.Phe58Leu Uncertain significance Single submitter
- A1BG p.Pro131His Uncertain significance Single submitter
- A1BG p.Pro177His Uncertain significance Single submitter
- A1BG p.Pro209Leu Uncertain significance Single submitter
- A1BG p.Pro296Leu Uncertain significance Single submitter
- A1BG p.Ser122Leu Uncertain significance Single submitter
- A1BG p.Ser294Asn Uncertain significance Single submitter
- A1BG p.Ser369Phe Uncertain significance Single submitter
- A1BG p.Ser482Thr Uncertain significance Single submitter
- A1BG p.Thr278Asn Uncertain significance Single submitter
- A1BG p.Thr48Met Uncertain significance Single submitter
- A1BG p.Val199Met Uncertain significance Single submitter
- A1BG p.Val460Leu Uncertain significance Single submitter
- A1BG p.Val488Glu Uncertain significance Single submitter
All A1BG variants
Likely benign 2
- p.Cys374Arg Single submitter
- p.Glu202Lys Single submitter
Uncertain significance 81
- p.Ala170Thr Single submitter ⚠
- p.Ala197Thr Single submitter ⚠
- p.Ala295Val Single submitter ⚠
- p.Ala308Glu Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala327Gly Single submitter ⚠
- p.Ala335Thr Single submitter ⚠
- p.Ala357Glu Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala51Gly Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg245His Single submitter ⚠
- p.Arg254Gly Single submitter ⚠
- p.Arg280Cys Single submitter ⚠
- p.Arg280His Single submitter ⚠
- p.Arg333Pro Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg447Cys Single submitter ⚠
- p.Arg473Gly Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Arg90His Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp155Glu Single submitter ⚠
- p.Asp240Asn Single submitter ⚠
- p.Asp273Gly Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp303Asn Single submitter ⚠
- p.Asp340Glu Single submitter ⚠
- p.Asp378Glu Single submitter ⚠
- p.Cys232Ser Single submitter ⚠
- p.Cys232Trp Single submitter ⚠
- p.Gln176His Single submitter ⚠
- p.Glu160Asp Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Glu356Lys Single submitter ⚠
- p.Glu437Asp Single submitter ⚠
- p.Glu439Asp Single submitter ⚠
- p.Glu489Gln Single submitter ⚠
- p.Glu68Asp Single submitter ⚠
- p.Gly132Arg Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly318Ser Single submitter ⚠
- p.Gly331Cys Single submitter ⚠
- p.Gly96Val Single submitter ⚠
- p.His52Pro Single submitter ⚠
- p.Leu116Phe Single submitter ⚠
- p.Leu133Val Single submitter ⚠
- p.Leu192Arg Single submitter ⚠
- p.Leu336Arg Single submitter ⚠
- p.Leu435Pro Single submitter ⚠
- p.Leu83Gln Single submitter ⚠
- p.Lys248Gln Single submitter ⚠
- p.Met3Ile Single submitter ⚠
- p.Phe172Ser Single submitter ⚠
- p.Phe58Leu Single submitter ⚠
- p.Pro131His Single submitter ⚠
- p.Pro177His Single submitter ⚠
- p.Pro209Leu Single submitter ⚠
- p.Pro235Thr Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro426Ala Single submitter ⚠
- p.Pro426Ser Single submitter ⚠
- p.Pro449Ala Single submitter ⚠
- p.Ser122Leu Single submitter ⚠
- p.Ser258Thr Single submitter ⚠
- p.Ser294Asn Single submitter ⚠
- p.Ser317Thr Single submitter ⚠
- p.Ser369Phe Single submitter ⚠
- p.Ser482Thr Single submitter ⚠
- p.Thr102Ser Single submitter ⚠
- p.Thr278Asn Single submitter ⚠
- p.Thr48Met Single submitter ⚠
- p.Thr87Ile Single submitter ⚠
- p.Val199Met Single submitter ⚠
- p.Val375Ile Single submitter ⚠
- p.Val460Leu Single submitter ⚠
- p.Val488Glu Single submitter ⚠