A4GNT — 57 ClinVar variants
All ClinVar germline A4GNT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
5 Likely benign · 52 Uncertain significance
Full A4GNT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- A4GNT p.Ala141Thr Uncertain significance Single submitter
- A4GNT p.Ala186Asp Uncertain significance Single submitter
- A4GNT p.Ala186Thr Uncertain significance Single submitter
- A4GNT p.Arg154Cys Uncertain significance Single submitter
- A4GNT p.Arg154Ser Uncertain significance Single submitter
- A4GNT p.Arg188Trp Uncertain significance Single submitter
- A4GNT p.Arg298Gln Uncertain significance Single submitter
- A4GNT p.Asn180Lys Uncertain significance Single submitter
-
A4GNT p.Asn192Asp
Uncertain significance
Single submitter
Inborn genetic diseases
- A4GNT p.Asn282Ser Uncertain significance Single submitter
- A4GNT p.Asp112Asn Uncertain significance Single submitter
- A4GNT p.Asp151Asn Uncertain significance Single submitter
- A4GNT p.Asp322Asn Uncertain significance Single submitter
- A4GNT p.Cys249Tyr Uncertain significance Single submitter
- A4GNT p.Gln295Glu Uncertain significance Single submitter
- A4GNT p.Glu309Gln Uncertain significance Single submitter
- A4GNT p.Gly297Arg Uncertain significance Single submitter
- A4GNT p.His256Gln Uncertain significance Single submitter
- A4GNT p.His65Arg Uncertain significance Single submitter
- A4GNT p.Ile52Val Uncertain significance Single submitter
- A4GNT p.Leu146Phe Uncertain significance Single submitter
- A4GNT p.Leu204Ser Uncertain significance Single submitter
- A4GNT p.Lys37Asn Uncertain significance Single submitter
- A4GNT p.Met96Lys Uncertain significance Single submitter
- A4GNT p.Phe19Leu Uncertain significance Single submitter
- A4GNT p.Pro64Leu Uncertain significance Single submitter
- A4GNT p.Ser280Asn Uncertain significance Single submitter
- A4GNT p.Ser280Thr Uncertain significance Single submitter
- A4GNT p.Trp133Arg Uncertain significance Single submitter
- A4GNT p.Trp220Ser Uncertain significance Single submitter
- A4GNT p.Tyr102Phe Uncertain significance Single submitter
- A4GNT p.Tyr271Cys Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- A4GNT p.Ala141Pro Uncertain significance Single submitter
- A4GNT p.Arg270His Uncertain significance Single submitter
- A4GNT p.Arg298Trp Uncertain significance Single submitter
- A4GNT p.Arg313Cys Uncertain significance Single submitter
- A4GNT p.Asn251His Uncertain significance Single submitter
- A4GNT p.Gly297Glu Uncertain significance Single submitter
- A4GNT p.Ile219Met Uncertain significance Single submitter
- A4GNT p.Leu198Phe Uncertain significance Single submitter
- A4GNT p.Leu232Phe Uncertain significance Single submitter
- A4GNT p.Met231Ile Uncertain significance Single submitter
- A4GNT p.Met293Arg Uncertain significance Single submitter
- A4GNT p.Phe195Leu Uncertain significance Single submitter
- A4GNT p.Pro118Leu Uncertain significance Single submitter
- A4GNT p.Pro129Ala Uncertain significance Single submitter
- A4GNT p.Pro202Leu Uncertain significance Single submitter
- A4GNT p.Pro257Leu Uncertain significance Single submitter
- A4GNT p.Ser93Phe Uncertain significance Single submitter
- A4GNT p.Ser98Pro Likely benign Single submitter
- A4GNT p.Tyr21Cys Uncertain significance Single submitter
- A4GNT p.Tyr312Cys Uncertain significance Single submitter
- A4GNT p.Val114Ile Uncertain significance Single submitter
All A4GNT variants
Likely benign 5
- p.Arg266Ter Multiple submitters
- p.Arg188Gln Single submitter
- p.His214Gln Single submitter
- p.Ile194Val Single submitter
- p.Ser98Pro Single submitter ⚠
Uncertain significance 52
- p.Ala141Pro Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala186Asp Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg154Ser Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg270His Single submitter ⚠
- p.Arg298Gln Single submitter ⚠
- p.Arg298Trp Single submitter ⚠
- p.Arg313Cys Single submitter ⚠
- p.Asn180Lys Single submitter ⚠
- p.Asn192Asp Single submitter Inborn genetic diseases ⚠
- p.Asn251His Single submitter ⚠
- p.Asn282Ser Single submitter ⚠
- p.Asp112Asn Single submitter ⚠
- p.Asp151Asn Single submitter ⚠
- p.Asp322Asn Single submitter ⚠
- p.Cys249Tyr Single submitter ⚠
- p.Gln295Glu Single submitter ⚠
- p.Glu309Gln Single submitter ⚠
- p.Gly297Arg Single submitter ⚠
- p.Gly297Glu Single submitter ⚠
- p.His256Gln Single submitter ⚠
- p.His65Arg Single submitter ⚠
- p.Ile219Met Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Leu204Ser Single submitter ⚠
- p.Leu232Phe Single submitter ⚠
- p.Lys37Asn Single submitter ⚠
- p.Met231Ile Single submitter ⚠
- p.Met293Arg Single submitter ⚠
- p.Met96Lys Single submitter ⚠
- p.Phe195Leu Single submitter ⚠
- p.Phe19Leu Single submitter ⚠
- p.Pro118Leu Single submitter ⚠
- p.Pro129Ala Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Ser280Asn Single submitter ⚠
- p.Ser280Thr Single submitter ⚠
- p.Ser93Phe Single submitter ⚠
- p.Trp133Arg Single submitter ⚠
- p.Trp220Ser Single submitter ⚠
- p.Tyr102Phe Single submitter ⚠
- p.Tyr21Cys Single submitter ⚠
- p.Tyr271Cys Single submitter ⚠
- p.Tyr312Cys Single submitter ⚠
- p.Val114Ile Single submitter ⚠