AATF — 90 ClinVar variants
All ClinVar germline AATF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
90 Uncertain significance
Full AATF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- AATF p.Ala198Pro Uncertain significance Single submitter
- AATF p.Ala198Thr Uncertain significance Single submitter
- AATF p.Ala247Val Uncertain significance Single submitter
- AATF p.Ala314Val Uncertain significance Single submitter
- AATF p.Ala377Pro Uncertain significance Single submitter
- AATF p.Ala60Val Uncertain significance Single submitter
- AATF p.Arg287Lys Uncertain significance Single submitter
- AATF p.Arg334Gln Uncertain significance Single submitter
- AATF p.Arg35Gly Uncertain significance Single submitter
- AATF p.Arg363Thr Uncertain significance Single submitter
- AATF p.Arg408Gln Uncertain significance Single submitter
- AATF p.Arg414Cys Uncertain significance Single submitter
- AATF p.Arg418Gln Uncertain significance Single submitter
- AATF p.Arg474Gln Uncertain significance Single submitter
- AATF p.Asn482Ser Uncertain significance Single submitter
- AATF p.Asp175Gly Uncertain significance Single submitter
- AATF p.Asp184Gly Uncertain significance Single submitter
- AATF p.Asp206Gly Uncertain significance Single submitter
- AATF p.Asp347Asn Uncertain significance Single submitter
- AATF p.Gln245Glu Uncertain significance Single submitter
- AATF p.Gln88His Uncertain significance Single submitter
- AATF p.Glu21Gln Uncertain significance Single submitter
- AATF p.Glu329Lys Uncertain significance Single submitter
- AATF p.Glu437Asp Uncertain significance Single submitter
- AATF p.Glu542Gly Uncertain significance Single submitter
- AATF p.Glu556Gln Uncertain significance Single submitter
- AATF p.Glu83Val Uncertain significance Single submitter
- AATF p.Gly111Glu Uncertain significance Single submitter
- AATF p.Gly183Glu Uncertain significance Single submitter
- AATF p.Gly199Arg Uncertain significance Single submitter
- AATF p.Gly3Val Uncertain significance Single submitter
- AATF p.Gly436Arg Uncertain significance Single submitter
- AATF p.Gly54Arg Uncertain significance Single submitter
- AATF p.His449Arg Uncertain significance Single submitter
- AATF p.Ile494Val Uncertain significance Single submitter
- AATF p.Lys216Glu Uncertain significance Single submitter
- AATF p.Lys264Arg Uncertain significance Single submitter
- AATF p.Lys331Gln Uncertain significance Single submitter
- AATF p.Lys373Glu Uncertain significance Single submitter
- AATF p.Lys500Ile Uncertain significance Single submitter
- AATF p.Met164Val Uncertain significance Single submitter
- AATF p.Met401Thr Uncertain significance Single submitter
- AATF p.Phe298Ser Uncertain significance Single submitter
- AATF p.Phe50Leu Uncertain significance Single submitter
- AATF p.Pro269Leu Uncertain significance Single submitter
- AATF p.Pro553His Uncertain significance Single submitter
- AATF p.Pro553Ser Uncertain significance Single submitter
- AATF p.Ser170Gly Uncertain significance Single submitter
- AATF p.Ser214Arg Uncertain significance Single submitter
- AATF p.Ser93Thr Uncertain significance Single submitter
- AATF p.Thr310Ala Uncertain significance Single submitter
- AATF p.Thr310Lys Uncertain significance Single submitter
- AATF p.Thr412Ser Uncertain significance Single submitter
- AATF p.Thr476Ser Uncertain significance Single submitter
- AATF p.Thr67Met Uncertain significance Single submitter
- AATF p.Trp86Gly Uncertain significance Single submitter
- AATF p.Val337Ile Uncertain significance Single submitter
- AATF p.Val505Ile Uncertain significance Single submitter
- AATF p.Val53Leu Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- AATF p.Ala226Thr Uncertain significance Single submitter
- AATF p.Ala2Gly Uncertain significance Single submitter
- AATF p.Arg335Thr Uncertain significance Single submitter
- AATF p.Arg355Cys Uncertain significance Single submitter
- AATF p.Arg474Trp Uncertain significance Single submitter
- AATF p.Asp121Asn Uncertain significance Single submitter
- AATF p.Asp372Asn Uncertain significance Single submitter
- AATF p.Asp483Asn Uncertain significance Single submitter
- AATF p.Gln368Glu Uncertain significance Single submitter
- AATF p.Gln495Arg Uncertain significance Single submitter
- AATF p.Glu115Lys Uncertain significance Single submitter
- AATF p.Glu119Val Uncertain significance Single submitter
- AATF p.Glu176Lys Uncertain significance Single submitter
- AATF p.Glu30Lys Uncertain significance Single submitter
- AATF p.Glu317Lys Uncertain significance Single submitter
- AATF p.Gly123Arg Uncertain significance Single submitter
- AATF p.Ile472Leu Uncertain significance Single submitter
- AATF p.Ile472Met Uncertain significance Single submitter
- AATF p.Leu15Trp Uncertain significance Single submitter
- AATF p.Leu376Val Uncertain significance Single submitter
- AATF p.Leu65Trp Uncertain significance Single submitter
- AATF p.Leu7Pro Uncertain significance Single submitter
- AATF p.Met527Thr Uncertain significance Single submitter
- AATF p.Pro24Leu Uncertain significance Single submitter
- AATF p.Pro423Leu Uncertain significance Single submitter
- AATF p.Pro529Thr Uncertain significance Single submitter
- AATF p.Ser178Asn Uncertain significance Single submitter
- AATF p.Ser99Cys Uncertain significance Single submitter
- AATF p.Tyr348Cys Uncertain significance Single submitter
- AATF p.Val307Gly Uncertain significance Single submitter
- AATF p.Val419Leu Uncertain significance Single submitter
All AATF variants
Uncertain significance 90
- p.Ala198Pro Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala226Thr Single submitter ⚠
- p.Ala247Val Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Ala377Pro Single submitter ⚠
- p.Ala60Val Single submitter ⚠
- p.Arg287Lys Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg335Thr Single submitter ⚠
- p.Arg355Cys Single submitter ⚠
- p.Arg35Gly Single submitter ⚠
- p.Arg363Thr Single submitter ⚠
- p.Arg408Gln Single submitter ⚠
- p.Arg414Cys Single submitter ⚠
- p.Arg418Gln Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg474Trp Single submitter ⚠
- p.Asn482Ser Single submitter ⚠
- p.Asp121Asn Single submitter ⚠
- p.Asp175Gly Single submitter ⚠
- p.Asp184Gly Single submitter ⚠
- p.Asp206Gly Single submitter ⚠
- p.Asp347Asn Single submitter ⚠
- p.Asp372Asn Single submitter ⚠
- p.Asp483Asn Single submitter ⚠
- p.Gln245Glu Single submitter ⚠
- p.Gln368Glu Single submitter ⚠
- p.Gln495Arg Single submitter ⚠
- p.Gln88His Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu119Val Single submitter ⚠
- p.Glu176Lys Single submitter ⚠
- p.Glu21Gln Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu437Asp Single submitter ⚠
- p.Glu542Gly Single submitter ⚠
- p.Glu556Gln Single submitter ⚠
- p.Glu83Val Single submitter ⚠
- p.Gly111Glu Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly183Glu Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly3Val Single submitter ⚠
- p.Gly436Arg Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.His449Arg Single submitter ⚠
- p.Ile472Leu Single submitter ⚠
- p.Ile472Met Single submitter ⚠
- p.Ile494Val Single submitter ⚠
- p.Leu15Trp Single submitter ⚠
- p.Leu376Val Single submitter ⚠
- p.Leu65Trp Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys216Glu Single submitter ⚠
- p.Lys264Arg Single submitter ⚠
- p.Lys331Gln Single submitter ⚠
- p.Lys373Glu Single submitter ⚠
- p.Lys500Ile Single submitter ⚠
- p.Met164Val Single submitter ⚠
- p.Met401Thr Single submitter ⚠
- p.Met527Thr Single submitter ⚠
- p.Phe298Ser Single submitter ⚠
- p.Phe50Leu Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro269Leu Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Pro529Thr Single submitter ⚠
- p.Pro553His Single submitter ⚠
- p.Pro553Ser Single submitter ⚠
- p.Ser170Gly Single submitter ⚠
- p.Ser178Asn Single submitter ⚠
- p.Ser214Arg Single submitter ⚠
- p.Ser93Thr Single submitter ⚠
- p.Ser99Cys Single submitter ⚠
- p.Thr310Ala Single submitter ⚠
- p.Thr310Lys Single submitter ⚠
- p.Thr412Ser Single submitter ⚠
- p.Thr476Ser Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Trp86Gly Single submitter ⚠
- p.Tyr348Cys Single submitter ⚠
- p.Val307Gly Single submitter ⚠
- p.Val337Ile Single submitter ⚠
- p.Val419Leu Single submitter ⚠
- p.Val505Ile Single submitter ⚠
- p.Val53Leu Single submitter ⚠