ABCB10 — 108 ClinVar variants
All ClinVar germline ABCB10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
3 Benign · 2 Likely benign · 103 Uncertain significance
Full ABCB10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABCB10 p.Ala110Pro Uncertain significance Single submitter
- ABCB10 p.Ala280Val Uncertain significance Single submitter
- ABCB10 p.Ala300Pro Uncertain significance Single submitter
- ABCB10 p.Ala461Val Uncertain significance Single submitter
- ABCB10 p.Ala600Thr Uncertain significance Single submitter
- ABCB10 p.Ala643Val Uncertain significance Single submitter
- ABCB10 p.Ala65Ser Uncertain significance Single submitter
- ABCB10 p.Arg101Ser Uncertain significance Single submitter
- ABCB10 p.Arg10Leu Uncertain significance Single submitter
- ABCB10 p.Arg10Pro Uncertain significance Single submitter
- ABCB10 p.Arg232His Uncertain significance Single submitter
- ABCB10 p.Arg395Trp Uncertain significance Single submitter
- ABCB10 p.Arg50Gly Uncertain significance Single submitter
- ABCB10 p.Asn210His Uncertain significance Single submitter
- ABCB10 p.Asn478Asp Uncertain significance Single submitter
- ABCB10 p.Asp382Glu Uncertain significance Single submitter
- ABCB10 p.Glu375Lys Uncertain significance Single submitter
- ABCB10 p.Gly121Ser Uncertain significance Single submitter
- ABCB10 p.Gly136Glu Uncertain significance Single submitter
- ABCB10 p.Gly142Arg Uncertain significance Single submitter
- ABCB10 p.Gly142Glu Uncertain significance Single submitter
- ABCB10 p.Gly145Arg Uncertain significance Single submitter
- ABCB10 p.Gly21Ser Uncertain significance Single submitter
- ABCB10 p.Gly38Arg Uncertain significance Single submitter
- ABCB10 p.Gly406Arg Uncertain significance Single submitter
- ABCB10 p.Gly713Arg Uncertain significance Single submitter
- ABCB10 p.Ile304Leu Uncertain significance Single submitter
- ABCB10 p.Ile517Val Uncertain significance Single submitter
- ABCB10 p.Ile709Val Uncertain significance Single submitter
- ABCB10 p.Ile725Val Uncertain significance Single submitter
- ABCB10 p.Leu51Arg Uncertain significance Single submitter
- ABCB10 p.Leu86Arg Uncertain significance Single submitter
- ABCB10 p.Lys159Arg Uncertain significance Single submitter
- ABCB10 p.Lys630Asn Uncertain significance Single submitter
- ABCB10 p.Met307Thr Uncertain significance Single submitter
- ABCB10 p.Met371Ile Uncertain significance Single submitter
- ABCB10 p.Met385Val Uncertain significance Single submitter
- ABCB10 p.Phe118Cys Uncertain significance Single submitter
- ABCB10 p.Phe262Cys Uncertain significance Single submitter
- ABCB10 p.Phe513Ser Uncertain significance Single submitter
- ABCB10 p.Pro111Ser Uncertain significance Single submitter
- ABCB10 p.Pro119Leu Uncertain significance Single submitter
- ABCB10 p.Pro14Arg Uncertain significance Single submitter
- ABCB10 p.Pro155Arg Uncertain significance Single submitter
- ABCB10 p.Pro25Arg Uncertain significance Single submitter
- ABCB10 p.Pro323Ser Uncertain significance Single submitter
- ABCB10 p.Pro37Arg Uncertain significance Single submitter
- ABCB10 p.Pro56Ser Uncertain significance Single submitter
- ABCB10 p.Ser311Leu Uncertain significance Single submitter
- ABCB10 p.Ser70Gly Uncertain significance Single submitter
- ABCB10 p.Thr694Ile Uncertain significance Single submitter
- ABCB10 p.Trp68Cys Uncertain significance Single submitter
- ABCB10 p.Val175Phe Uncertain significance Single submitter
- ABCB10 p.Val26Ala Uncertain significance Single submitter
- ABCB10 p.Val322Ala Uncertain significance Single submitter
- ABCB10 p.Val36Leu Uncertain significance Single submitter
- ABCB10 p.Val428Gly Uncertain significance Single submitter
- ABCB10 p.Val526Leu Uncertain significance Single submitter
- ABCB10 p.Val564Gly Uncertain significance Single submitter
- ABCB10 p.Val62Phe Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- ABCB10 p.Ala388Gly Uncertain significance Single submitter
- ABCB10 p.Ala394Thr Uncertain significance Single submitter
- ABCB10 p.Ala503Asp Uncertain significance Single submitter
- ABCB10 p.Arg213His Uncertain significance Single submitter
- ABCB10 p.Arg22Trp Uncertain significance Single submitter
- ABCB10 p.Arg242Cys Uncertain significance Single submitter
- ABCB10 p.Arg242His Uncertain significance Single submitter
- ABCB10 p.Arg267Cys Uncertain significance Single submitter
- ABCB10 p.Arg274His Uncertain significance Single submitter
- ABCB10 p.Arg284Cys Uncertain significance Single submitter
- ABCB10 p.Arg334Gln Uncertain significance Single submitter
- ABCB10 p.Arg337Gln Uncertain significance Single submitter
- ABCB10 p.Arg357His Uncertain significance Single submitter
- ABCB10 p.Arg605Gly Uncertain significance Single submitter
- ABCB10 p.Arg617Trp Uncertain significance Single submitter
- ABCB10 p.Arg95His Uncertain significance Single submitter
- ABCB10 p.Asn202Ser Uncertain significance Single submitter
- ABCB10 p.Asn611Ser Uncertain significance Single submitter
- ABCB10 p.Asp143Asn Uncertain significance Single submitter
- ABCB10 p.Asp677Asn Uncertain significance Single submitter
- ABCB10 p.Glu506Gly Uncertain significance Single submitter
- ABCB10 p.His556Arg Uncertain significance Single submitter
- ABCB10 p.His715Asp Uncertain significance Single submitter
- ABCB10 p.Ile195Met Uncertain significance Single submitter
- ABCB10 p.Ile255Val Likely benign Single submitter
- ABCB10 p.Ile328Thr Uncertain significance Single submitter
- ABCB10 p.Leu218Phe Uncertain significance Single submitter
- ABCB10 p.Lys341Thr Uncertain significance Single submitter
- ABCB10 p.Lys495Glu Uncertain significance Single submitter
- ABCB10 p.Met436Ile Uncertain significance Single submitter
- ABCB10 p.Phe439Leu Uncertain significance Single submitter
- ABCB10 p.Pro312Ser Uncertain significance Single submitter
- ABCB10 p.Ser182Gly Uncertain significance Single submitter
- ABCB10 p.Ser453Leu Uncertain significance Single submitter
- ABCB10 p.Thr279Ser Uncertain significance Single submitter
- ABCB10 p.Thr44Ile Uncertain significance Single submitter
- ABCB10 p.Thr550Ala Uncertain significance Single submitter
- ABCB10 p.Thr684Met Uncertain significance Single submitter
- ABCB10 p.Tyr200Phe Uncertain significance Single submitter
- ABCB10 p.Val36Ile Uncertain significance Single submitter
- ABCB10 p.Val428Met Uncertain significance Single submitter
- ABCB10 p.Val481Phe Uncertain significance Single submitter
- ABCB10 p.Val507Leu Uncertain significance Single submitter
- ABCB10 p.Val507Met Uncertain significance Single submitter
All ABCB10 variants
Benign 3
- p.Asn478Lys Multiple submitters
- p.Thr179= Multiple submitters
- c.1646-24TTCCT[2] Single submitter
Likely benign 2
- p.Ile255Val Single submitter ⚠
- p.Pro518= Single submitter
Uncertain significance 103
- p.Ala110Pro Single submitter ⚠
- p.Ala280Val Single submitter ⚠
- p.Ala300Pro Single submitter ⚠
- p.Ala388Gly Single submitter ⚠
- p.Ala394Thr Single submitter ⚠
- p.Ala461Val Single submitter ⚠
- p.Ala503Asp Single submitter ⚠
- p.Ala600Thr Single submitter ⚠
- p.Ala643Val Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Arg101Ser Single submitter ⚠
- p.Arg10Leu Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg213His Single submitter ⚠
- p.Arg22Trp Single submitter ⚠
- p.Arg232His Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg267Cys Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Arg284Cys Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg337Gln Single submitter ⚠
- p.Arg357His Single submitter ⚠
- p.Arg395Trp Single submitter ⚠
- p.Arg50Gly Single submitter ⚠
- p.Arg605Gly Single submitter ⚠
- p.Arg617Trp Single submitter ⚠
- p.Arg95His Single submitter ⚠
- p.Asn202Ser Single submitter ⚠
- p.Asn210His Single submitter ⚠
- p.Asn478Asp Single submitter ⚠
- p.Asn611Ser Single submitter ⚠
- p.Asp143Asn Single submitter ⚠
- p.Asp382Glu Single submitter ⚠
- p.Asp677Asn Single submitter ⚠
- p.Glu375Lys Single submitter ⚠
- p.Glu506Gly Single submitter ⚠
- p.Gly121Ser Single submitter ⚠
- p.Gly136Glu Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly142Glu Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly21Ser Single submitter ⚠
- p.Gly38Arg Single submitter ⚠
- p.Gly406Arg Single submitter ⚠
- p.Gly713Arg Single submitter ⚠
- p.His556Arg Single submitter ⚠
- p.His715Asp Single submitter ⚠
- p.Ile195Met Single submitter ⚠
- p.Ile304Leu Single submitter ⚠
- p.Ile328Thr Single submitter ⚠
- p.Ile517Val Single submitter ⚠
- p.Ile709Val Single submitter ⚠
- p.Ile725Val Single submitter ⚠
- p.Leu218Phe Single submitter ⚠
- p.Leu51Arg Single submitter ⚠
- p.Leu86Arg Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Lys341Thr Single submitter ⚠
- p.Lys495Glu Single submitter ⚠
- p.Lys630Asn Single submitter ⚠
- p.Met307Thr Single submitter ⚠
- p.Met371Ile Single submitter ⚠
- p.Met385Val Single submitter ⚠
- p.Met436Ile Single submitter ⚠
- p.Phe118Cys Single submitter ⚠
- p.Phe262Cys Single submitter ⚠
- p.Phe439Leu Single submitter ⚠
- p.Phe513Ser Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro119Leu Single submitter ⚠
- p.Pro14Arg Single submitter ⚠
- p.Pro155Arg Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro312Ser Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro37Arg Single submitter ⚠
- p.Pro56Ser Single submitter ⚠
- p.Ser182Gly Single submitter ⚠
- p.Ser311Leu Single submitter ⚠
- p.Ser453Leu Single submitter ⚠
- p.Ser70Gly Single submitter ⚠
- p.Thr279Ser Single submitter ⚠
- p.Thr44Ile Single submitter ⚠
- p.Thr550Ala Single submitter ⚠
- p.Thr684Met Single submitter ⚠
- p.Thr694Ile Single submitter ⚠
- p.Trp68Cys Single submitter ⚠
- p.Tyr200Phe Single submitter ⚠
- p.Val175Phe Single submitter ⚠
- p.Val26Ala Single submitter ⚠
- p.Val322Ala Single submitter ⚠
- p.Val36Ile Single submitter ⚠
- p.Val36Leu Single submitter ⚠
- p.Val428Gly Single submitter ⚠
- p.Val428Met Single submitter ⚠
- p.Val481Phe Single submitter ⚠
- p.Val507Leu Single submitter ⚠
- p.Val507Met Single submitter ⚠
- p.Val526Leu Single submitter ⚠
- p.Val564Gly Single submitter ⚠
- p.Val62Phe Single submitter ⚠