ABCB9 — 153 ClinVar variants
All ClinVar germline ABCB9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 136 flagged for review →
18 Likely benign · 135 Uncertain significance
Full ABCB9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 136
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABCB9 p.Ala151Val Uncertain significance Single submitter
- ABCB9 p.Ala169Thr Uncertain significance Single submitter
- ABCB9 p.Ala364Val Uncertain significance Single submitter
- ABCB9 p.Ala368Val Uncertain significance Single submitter
- ABCB9 p.Ala447Thr Uncertain significance Single submitter
- ABCB9 p.Ala641Ser Uncertain significance Single submitter
- ABCB9 p.Ala641Thr Uncertain significance Single submitter
- ABCB9 p.Ala698Val Uncertain significance Single submitter
- ABCB9 p.Ala6Val Uncertain significance Single submitter
- ABCB9 p.Ala707Thr Uncertain significance Single submitter
- ABCB9 p.Ala73Val Uncertain significance Single submitter
- ABCB9 p.Ala760Thr Uncertain significance Single submitter
- ABCB9 p.Arg108His Uncertain significance Single submitter
- ABCB9 p.Arg112Gln Uncertain significance Single submitter
- ABCB9 p.Arg112Trp Uncertain significance Single submitter
- ABCB9 p.Arg141Gln Uncertain significance Single submitter
- ABCB9 p.Arg246Trp Uncertain significance Single submitter
- ABCB9 p.Arg260Cys Uncertain significance Single submitter
- ABCB9 p.Arg288Cys Uncertain significance Single submitter
- ABCB9 p.Arg514His Uncertain significance Single submitter
- ABCB9 p.Arg562Gln Uncertain significance Single submitter
- ABCB9 p.Arg659Trp Uncertain significance Single submitter
- ABCB9 p.Asn71Asp Uncertain significance Single submitter
- ABCB9 p.Asp184Asn Uncertain significance Single submitter
- ABCB9 p.Asp492Asn Uncertain significance Single submitter
- ABCB9 p.Asp574Asn Uncertain significance Single submitter
- ABCB9 p.Gln224Arg Uncertain significance Single submitter
- ABCB9 p.Glu167Lys Uncertain significance Single submitter
- ABCB9 p.Glu757Lys Uncertain significance Single submitter
- ABCB9 p.Gly143Arg Uncertain significance Single submitter
- ABCB9 p.Gly215Ser Uncertain significance Single submitter
- ABCB9 p.Gly247Val Uncertain significance Single submitter
- ABCB9 p.Gly431Arg Uncertain significance Single submitter
- ABCB9 p.Gly561Asp Uncertain significance Single submitter
- ABCB9 p.Gly623Ser Uncertain significance Single submitter
- ABCB9 p.Ile216Val Uncertain significance Single submitter
- ABCB9 p.Ile245Val Uncertain significance Single submitter
- ABCB9 p.Ile253Thr Uncertain significance Single submitter
- ABCB9 p.Ile338Leu Uncertain significance Single submitter
- ABCB9 p.Ile570Val Uncertain significance Single submitter
- ABCB9 p.Leu174Pro Uncertain significance Single submitter
- ABCB9 p.Leu299Val Uncertain significance Single submitter
- ABCB9 p.Leu689Pro Uncertain significance Single submitter
- ABCB9 p.Leu88Phe Uncertain significance Single submitter
- ABCB9 p.Lys376Arg Uncertain significance Single submitter
- ABCB9 p.Lys765Arg Uncertain significance Single submitter
- ABCB9 p.Met14Val Uncertain significance Single submitter
- ABCB9 p.Met459Thr Uncertain significance Single submitter
- ABCB9 p.Met98Ile Uncertain significance Single submitter
- ABCB9 p.Met98Thr Uncertain significance Single submitter
- ABCB9 p.Met98Val Uncertain significance Single submitter
- ABCB9 p.Phe187Leu Uncertain significance Single submitter
- ABCB9 p.Phe276Leu Uncertain significance Single submitter
- ABCB9 p.Phe511Leu Uncertain significance Single submitter
- ABCB9 p.Pro110Leu Uncertain significance Single submitter
- ABCB9 p.Pro149Ser Uncertain significance Single submitter
- ABCB9 p.Pro165Leu Uncertain significance Single submitter
- ABCB9 p.Pro487Gln Uncertain significance Single submitter
- ABCB9 p.Ser46Leu Uncertain significance Single submitter
- ABCB9 p.Ser494Ile Uncertain significance Single submitter
- ABCB9 p.Ser494Thr Uncertain significance Single submitter
- ABCB9 p.Thr139Ala Uncertain significance Single submitter
- ABCB9 p.Thr315Met Uncertain significance Single submitter
- ABCB9 p.Thr515Ile Uncertain significance Single submitter
- ABCB9 p.Thr670Ala Uncertain significance Single submitter
- ABCB9 p.Trp326Arg Uncertain significance Single submitter
- ABCB9 p.Val121Leu Uncertain significance Single submitter
- ABCB9 p.Val189Leu Uncertain significance Single submitter
- ABCB9 p.Val197Met Uncertain significance Single submitter
- ABCB9 p.Val270Met Uncertain significance Single submitter
- ABCB9 p.Val390Leu Uncertain significance Single submitter
- ABCB9 p.Val462Met Uncertain significance Single submitter
- ABCB9 p.Val47Met Uncertain significance Single submitter
- ABCB9 p.Val712Leu Uncertain significance Single submitter
- ABCB9 p.Val8Leu Uncertain significance Single submitter
- ABCB9 p.Val93Met Uncertain significance Single submitter
- ABCB9 p.Val99Ala Uncertain significance Single submitter
Predictors split 59
The independent predictors disagree with each other — read with care.
- ABCB9 p.Ala64Thr Uncertain significance Single submitter
- ABCB9 p.Arg211Gly Uncertain significance Single submitter
- ABCB9 p.Arg281His Uncertain significance Single submitter
- ABCB9 p.Arg2Trp Uncertain significance Single submitter
- ABCB9 p.Arg393Trp Uncertain significance Single submitter
- ABCB9 p.Arg39Cys Uncertain significance Single submitter
- ABCB9 p.Arg39His Uncertain significance Single submitter
- ABCB9 p.Arg403Gly Uncertain significance Single submitter
- ABCB9 p.Arg485Gln Uncertain significance Single submitter
- ABCB9 p.Arg503Gln Uncertain significance Single submitter
- ABCB9 p.Arg514Cys Uncertain significance Single submitter
- ABCB9 p.Arg562Trp Uncertain significance Single submitter
- ABCB9 p.Arg594Cys Uncertain significance Single submitter
- ABCB9 p.Arg717Cys Uncertain significance Single submitter
- ABCB9 p.Arg717His Uncertain significance Single submitter
- ABCB9 p.Arg740Gln Uncertain significance Single submitter
- ABCB9 p.Arg78Trp Uncertain significance Single submitter
- ABCB9 p.Arg80Trp Uncertain significance Single submitter
- ABCB9 p.Asn305Ser Uncertain significance Single submitter
- ABCB9 p.Asn554Tyr Uncertain significance Single submitter
- ABCB9 p.Asp492Tyr Uncertain significance Single submitter
- ABCB9 p.Asp498Asn Uncertain significance Single submitter
- ABCB9 p.Gln439His Uncertain significance Single submitter
- ABCB9 p.Glu676Lys Uncertain significance Single submitter
- ABCB9 p.Glu678Gln Uncertain significance Single submitter
- ABCB9 p.Gly248Ser Uncertain significance Single submitter
- ABCB9 p.Gly438Arg Uncertain significance Single submitter
- ABCB9 p.Gly443Ser Uncertain significance Single submitter
- ABCB9 p.Gly532Ser Uncertain significance Single submitter
- ABCB9 p.Gly567Ser Uncertain significance Single submitter
- ABCB9 p.Gly631Ser Uncertain significance Single submitter
- ABCB9 p.Gly687Asp Uncertain significance Single submitter
- ABCB9 p.Gly732Ser Uncertain significance Single submitter
- ABCB9 p.His518Leu Uncertain significance Single submitter
- ABCB9 p.Ile596Val Uncertain significance Single submitter
- ABCB9 p.Leu324Phe Uncertain significance Single submitter
- ABCB9 p.Leu455Val Uncertain significance Single submitter
- ABCB9 p.Lys348Glu Uncertain significance Single submitter
- ABCB9 p.Phe13Ser Uncertain significance Single submitter
- ABCB9 p.Pro531Leu Uncertain significance Single submitter
- ABCB9 p.Pro76Leu Uncertain significance Single submitter
- ABCB9 p.Ser291Leu Uncertain significance Single submitter
- ABCB9 p.Ser467Gly Uncertain significance Single submitter
- ABCB9 p.Ser72Gly Uncertain significance Single submitter
- ABCB9 p.Thr173Met Uncertain significance Single submitter
- ABCB9 p.Thr203Ala Uncertain significance Single submitter
- ABCB9 p.Thr209Met Uncertain significance Single submitter
- ABCB9 p.Thr22Met Uncertain significance Single submitter
- ABCB9 p.Thr22Pro Uncertain significance Single submitter
- ABCB9 p.Thr535Met Uncertain significance Single submitter
- ABCB9 p.Tyr208His Uncertain significance Single submitter
- ABCB9 p.Val16Met Likely benign Single submitter
- ABCB9 p.Val189Met Uncertain significance Single submitter
- ABCB9 p.Val465Ile Uncertain significance Single submitter
- ABCB9 p.Val473Ala Uncertain significance Single submitter
- ABCB9 p.Val590Leu Uncertain significance Single submitter
- ABCB9 p.Val613Ala Uncertain significance Single submitter
- ABCB9 p.Val718Ile Uncertain significance Single submitter
- ABCB9 p.Val89Met Uncertain significance Single submitter
All ABCB9 variants
Likely benign 18
- p.Ala698= Single submitter
- p.Ala707= Single submitter
- p.Ala729= Single submitter
- p.Ala748= Single submitter
- p.Arg2Gln Single submitter
- p.Arg717= Single submitter
- p.Asn756= Single submitter
- p.Gly744= Single submitter
- p.His706= Single submitter
- p.Ile253Val Single submitter
- p.Leu689= Single submitter
- p.Leu709= Single submitter
- p.Ser530Cys Single submitter
- p.Thr693= Single submitter
- p.Thr703= Single submitter
- p.Val16Met Single submitter ⚠
- p.Val230Ile Single submitter
- p.Val232Met Single submitter
Uncertain significance 135
- p.Ala151Val Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala364Val Single submitter ⚠
- p.Ala368Val Single submitter ⚠
- p.Ala447Thr Single submitter ⚠
- p.Ala641Ser Single submitter ⚠
- p.Ala641Thr Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala698Val Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala707Thr Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Ala760Thr Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg112Trp Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg211Gly Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Arg260Cys Single submitter ⚠
- p.Arg281His Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg2Trp Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg403Gly Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Arg503Gln Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg514His Single submitter ⚠
- p.Arg562Gln Single submitter ⚠
- p.Arg562Trp Single submitter ⚠
- p.Arg594Cys Single submitter ⚠
- p.Arg659Trp Single submitter ⚠
- p.Arg717Cys Single submitter ⚠
- p.Arg717His Single submitter ⚠
- p.Arg740Gln Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn305Ser Single submitter ⚠
- p.Asn554Tyr Single submitter ⚠
- p.Asn71Asp Single submitter ⚠
- p.Asp184Asn Single submitter ⚠
- p.Asp492Asn Single submitter ⚠
- p.Asp492Tyr Single submitter ⚠
- p.Asp498Asn Single submitter ⚠
- p.Asp574Asn Single submitter ⚠
- p.Gln224Arg Single submitter ⚠
- p.Gln439His Single submitter ⚠
- p.Glu167Lys Single submitter ⚠
- p.Glu676Lys Single submitter ⚠
- p.Glu678Gln Single submitter ⚠
- p.Glu757Lys Single submitter ⚠
- p.Gly143Arg Single submitter ⚠
- p.Gly215Ser Single submitter ⚠
- p.Gly247Val Single submitter ⚠
- p.Gly248Ser Single submitter ⚠
- p.Gly431Arg Single submitter ⚠
- p.Gly438Arg Single submitter ⚠
- p.Gly443Ser Single submitter ⚠
- p.Gly532Ser Single submitter ⚠
- p.Gly561Asp Single submitter ⚠
- p.Gly567Ser Single submitter ⚠
- p.Gly623Ser Single submitter ⚠
- p.Gly631Ser Single submitter ⚠
- p.Gly687Asp Single submitter ⚠
- p.Gly732Ser Single submitter ⚠
- p.His518Leu Single submitter ⚠
- p.Ile216Val Single submitter ⚠
- p.Ile245Val Single submitter ⚠
- p.Ile253Thr Single submitter ⚠
- p.Ile338Leu Single submitter ⚠
- p.Ile570Val Single submitter ⚠
- p.Ile596Val Single submitter ⚠
- p.Leu174Pro Single submitter ⚠
- p.Leu299Val Single submitter ⚠
- p.Leu324Phe Single submitter ⚠
- p.Leu455Val Single submitter ⚠
- p.Leu689Pro Single submitter ⚠
- p.Leu88Phe Single submitter ⚠
- p.Lys348Glu Single submitter ⚠
- p.Lys376Arg Single submitter ⚠
- p.Lys765Arg Single submitter ⚠
- p.Met14Val Single submitter ⚠
- p.Met459Thr Single submitter ⚠
- p.Met98Ile Single submitter ⚠
- p.Met98Thr Single submitter ⚠
- p.Met98Val Single submitter ⚠
- p.Phe13Ser Single submitter ⚠
- p.Phe187Leu Single submitter ⚠
- p.Phe276Leu Single submitter ⚠
- p.Phe511Leu Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro487Gln Single submitter ⚠
- p.Pro531Leu Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser291Leu Single submitter ⚠
- p.Ser467Gly Single submitter ⚠
- p.Ser46Leu Single submitter ⚠
- p.Ser494Ile Single submitter ⚠
- p.Ser494Thr Single submitter ⚠
- p.Ser72Gly Single submitter ⚠
- p.Thr139Ala Single submitter ⚠
- p.Thr173Met Single submitter ⚠
- p.Thr203Ala Single submitter ⚠
- p.Thr209Met Single submitter ⚠
- p.Thr22Met Single submitter ⚠
- p.Thr22Pro Single submitter ⚠
- p.Thr315Met Single submitter ⚠
- p.Thr515Ile Single submitter ⚠
- p.Thr535Met Single submitter ⚠
- p.Thr670Ala Single submitter ⚠
- p.Trp326Arg Single submitter ⚠
- p.Tyr208His Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val189Leu Single submitter ⚠
- p.Val189Met Single submitter ⚠
- p.Val197Met Single submitter ⚠
- p.Val270Met Single submitter ⚠
- p.Val390Leu Single submitter ⚠
- p.Val462Met Single submitter ⚠
- p.Val465Ile Single submitter ⚠
- p.Val473Ala Single submitter ⚠
- p.Val47Met Single submitter ⚠
- p.Val590Leu Single submitter ⚠
- p.Val613Ala Single submitter ⚠
- p.Val712Leu Single submitter ⚠
- p.Val718Ile Single submitter ⚠
- p.Val89Met Single submitter ⚠
- p.Val8Leu Single submitter ⚠
- p.Val93Met Single submitter ⚠
- p.Val99Ala Single submitter ⚠