ABCF3 — 94 ClinVar variants
All ClinVar germline ABCF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
2 Likely benign · 92 Uncertain significance
Full ABCF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABCF3 p.Ala280Thr Uncertain significance Single submitter
- ABCF3 p.Ala697Thr Uncertain significance Single submitter
- ABCF3 p.Arg112Lys Uncertain significance Single submitter
- ABCF3 p.Arg204Leu Uncertain significance Single submitter
- ABCF3 p.Arg205Cys Uncertain significance Single submitter
- ABCF3 p.Arg419Trp Uncertain significance Single submitter
- ABCF3 p.Arg520His Uncertain significance Single submitter
- ABCF3 p.Arg549Thr Uncertain significance Single submitter
- ABCF3 p.Arg591His Uncertain significance Single submitter
- ABCF3 p.Asn182Ile Uncertain significance Single submitter
- ABCF3 p.Asn422Asp Uncertain significance Single submitter
- ABCF3 p.Asp101Gly Uncertain significance Single submitter
- ABCF3 p.Asp189Asn Uncertain significance Single submitter
- ABCF3 p.Asp347Gly Uncertain significance Single submitter
- ABCF3 p.Asp352Glu Uncertain significance Single submitter
- ABCF3 p.Asp39Glu Uncertain significance Single submitter
- ABCF3 p.Gln274Glu Uncertain significance Single submitter
- ABCF3 p.Gln66Pro Uncertain significance Single submitter
- ABCF3 p.Glu256Lys Uncertain significance Single submitter
- ABCF3 p.Gly684Ser Uncertain significance Single submitter
- ABCF3 p.Ile491Val Uncertain significance Single submitter
- ABCF3 p.Leu130Ile Uncertain significance Single submitter
- ABCF3 p.Leu295Arg Uncertain significance Single submitter
- ABCF3 p.Leu348Phe Uncertain significance Single submitter
- ABCF3 p.Leu420Pro Uncertain significance Single submitter
- ABCF3 p.Leu47Val Uncertain significance Single submitter
- ABCF3 p.Leu538Phe Uncertain significance Single submitter
- ABCF3 p.Lys294Arg Uncertain significance Single submitter
- ABCF3 p.Met222Leu Uncertain significance Single submitter
- ABCF3 p.Met320Ile Uncertain significance Single submitter
- ABCF3 p.Met534Ile Uncertain significance Single submitter
- ABCF3 p.Met605Thr Uncertain significance Single submitter
- ABCF3 p.Pro374Arg Uncertain significance Single submitter
- ABCF3 p.Ser10Arg Uncertain significance Single submitter
- ABCF3 p.Ser169Thr Uncertain significance Single submitter
- ABCF3 p.Ser170Ala Uncertain significance Single submitter
- ABCF3 p.Ser175Phe Uncertain significance Single submitter
- ABCF3 p.Ser235Thr Uncertain significance Single submitter
- ABCF3 p.Ser259Arg Uncertain significance Single submitter
- ABCF3 p.Ser259Ile Uncertain significance Single submitter
- ABCF3 p.Ser415Asn Uncertain significance Single submitter
- ABCF3 p.Thr376Asn Uncertain significance Single submitter
- ABCF3 p.Val19Ile Uncertain significance Single submitter
- ABCF3 p.Val476Ile Uncertain significance Single submitter
-
ABCF3 p.Arg443Trp
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 48
The independent predictors disagree with each other — read with care.
- ABCF3 p.Ala128Ser Uncertain significance Single submitter
- ABCF3 p.Ala196Val Uncertain significance Single submitter
- ABCF3 p.Ala280Val Likely benign Single submitter
- ABCF3 p.Ala293Thr Uncertain significance Single submitter
- ABCF3 p.Ala303Gly Uncertain significance Single submitter
- ABCF3 p.Ala312Gly Uncertain significance Single submitter
- ABCF3 p.Ala312Thr Uncertain significance Single submitter
- ABCF3 p.Ala391Thr Uncertain significance Single submitter
- ABCF3 p.Ala574Thr Uncertain significance Single submitter
- ABCF3 p.Ala63Thr Uncertain significance Single submitter
- ABCF3 p.Arg204His Uncertain significance Single submitter
- ABCF3 p.Arg326Trp Uncertain significance Single submitter
- ABCF3 p.Arg384Cys Uncertain significance Single submitter
- ABCF3 p.Arg384His Uncertain significance Single submitter
- ABCF3 p.Arg406Gln Uncertain significance Single submitter
- ABCF3 p.Arg580Cys Uncertain significance Single submitter
- ABCF3 p.Arg585Trp Uncertain significance Single submitter
- ABCF3 p.Arg596Trp Uncertain significance Single submitter
- ABCF3 p.Arg704Cys Uncertain significance Single submitter
- ABCF3 p.Arg704His Uncertain significance Single submitter
- ABCF3 p.Arg705Cys Uncertain significance Single submitter
- ABCF3 p.Arg705His Uncertain significance Single submitter
- ABCF3 p.Asn449Ser Uncertain significance Single submitter
- ABCF3 p.Asn70His Uncertain significance Single submitter
- ABCF3 p.Asp21Val Uncertain significance Single submitter
- ABCF3 p.Asp247Gly Uncertain significance Single submitter
- ABCF3 p.Asp263Tyr Uncertain significance Single submitter
- ABCF3 p.Asp263Val Uncertain significance Single submitter
- ABCF3 p.Asp301Glu Uncertain significance Single submitter
- ABCF3 p.Glu124Lys Uncertain significance Single submitter
- ABCF3 p.Glu290Val Uncertain significance Single submitter
- ABCF3 p.Glu46Gln Uncertain significance Single submitter
- ABCF3 p.Gly684Cys Uncertain significance Single submitter
- ABCF3 p.Ile557Met Uncertain significance Single submitter
- ABCF3 p.Phe484Ser Uncertain significance Single submitter
- ABCF3 p.Pro324Leu Uncertain significance Single submitter
- ABCF3 p.Ser488Leu Uncertain significance Single submitter
- ABCF3 p.Ser509Ile Uncertain significance Single submitter
- ABCF3 p.Ser561Cys Uncertain significance Single submitter
- ABCF3 p.Ser617Gly Uncertain significance Single submitter
- ABCF3 p.Thr248Asn Uncertain significance Single submitter
- ABCF3 p.Thr372Met Uncertain significance Single submitter
- ABCF3 p.Tyr292Ser Uncertain significance Single submitter
- ABCF3 p.Tyr69Cys Uncertain significance Single submitter
- ABCF3 p.Val239Ile Uncertain significance Single submitter
- ABCF3 p.Val380Ile Uncertain significance Single submitter
- ABCF3 p.Val513Met Uncertain significance Single submitter
- ABCF3 p.Val575Leu Uncertain significance Single submitter
All ABCF3 variants
Likely benign 2
- p.Ala280Val Single submitter ⚠
- p.Leu464= Single submitter
Uncertain significance 92
- p.Ala128Ser Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala303Gly Single submitter ⚠
- p.Ala312Gly Single submitter ⚠
- p.Ala312Thr Single submitter ⚠
- p.Ala391Thr Single submitter ⚠
- p.Ala574Thr Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Ala697Thr Single submitter ⚠
- p.Arg112Lys Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Arg204Leu Single submitter ⚠
- p.Arg205Cys Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg406Gln Single submitter ⚠
- p.Arg419Trp Single submitter ⚠
- p.Arg520His Single submitter ⚠
- p.Arg549Thr Single submitter ⚠
- p.Arg580Cys Single submitter ⚠
- p.Arg585Trp Single submitter ⚠
- p.Arg591His Single submitter ⚠
- p.Arg596Trp Single submitter ⚠
- p.Arg704Cys Single submitter ⚠
- p.Arg704His Single submitter ⚠
- p.Arg705Cys Single submitter ⚠
- p.Arg705His Single submitter ⚠
- p.Asn182Ile Single submitter ⚠
- p.Asn422Asp Single submitter ⚠
- p.Asn449Ser Single submitter ⚠
- p.Asn70His Single submitter ⚠
- p.Asp101Gly Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp21Val Single submitter ⚠
- p.Asp247Gly Single submitter ⚠
- p.Asp263Tyr Single submitter ⚠
- p.Asp263Val Single submitter ⚠
- p.Asp301Glu Single submitter ⚠
- p.Asp347Gly Single submitter ⚠
- p.Asp352Glu Single submitter ⚠
- p.Asp39Glu Single submitter ⚠
- p.Gln274Glu Single submitter ⚠
- p.Gln66Pro Single submitter ⚠
- p.Glu124Lys Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu290Val Single submitter ⚠
- p.Glu46Gln Single submitter ⚠
- p.Gly684Cys Single submitter ⚠
- p.Gly684Ser Single submitter ⚠
- p.Ile491Val Single submitter ⚠
- p.Ile557Met Single submitter ⚠
- p.Leu130Ile Single submitter ⚠
- p.Leu295Arg Single submitter ⚠
- p.Leu348Phe Single submitter ⚠
- p.Leu420Pro Single submitter ⚠
- p.Leu47Val Single submitter ⚠
- p.Leu538Phe Single submitter ⚠
- p.Lys294Arg Single submitter ⚠
- p.Met222Leu Single submitter ⚠
- p.Met320Ile Single submitter ⚠
- p.Met534Ile Single submitter ⚠
- p.Met605Thr Single submitter ⚠
- p.Phe484Ser Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro374Arg Single submitter ⚠
- p.Ser10Arg Single submitter ⚠
- p.Ser169Thr Single submitter ⚠
- p.Ser170Ala Single submitter ⚠
- p.Ser175Phe Single submitter ⚠
- p.Ser235Thr Single submitter ⚠
- p.Ser259Arg Single submitter ⚠
- p.Ser259Ile Single submitter ⚠
- p.Ser415Asn Single submitter ⚠
- p.Ser488Leu Single submitter ⚠
- p.Ser509Ile Single submitter ⚠
- p.Ser561Cys Single submitter ⚠
- p.Ser617Gly Single submitter ⚠
- p.Thr248Asn Single submitter ⚠
- p.Thr372Met Single submitter ⚠
- p.Thr376Asn Single submitter ⚠
- p.Tyr292Ser Single submitter ⚠
- p.Tyr69Cys Single submitter ⚠
- p.Val19Ile Single submitter ⚠
- p.Val239Ile Single submitter ⚠
- p.Val380Ile Single submitter ⚠
- p.Val476Ile Single submitter ⚠
- p.Val513Met Single submitter ⚠
- p.Val575Leu Single submitter ⚠
- p.Arg443Trp No assertion criteria prostate cancer ⚠