ABCG4 — 61 ClinVar variants
All ClinVar germline ABCG4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
3 Benign · 4 Likely benign · 54 Uncertain significance
Full ABCG4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABCG4 p.Ala17Pro Uncertain significance Single submitter
- ABCG4 p.Ala19Thr Uncertain significance Single submitter
- ABCG4 p.Ala19Val Uncertain significance Single submitter
- ABCG4 p.Ala212Thr Uncertain significance Single submitter
- ABCG4 p.Ala234Ser Uncertain significance Single submitter
- ABCG4 p.Ala28Thr Uncertain significance Single submitter
- ABCG4 p.Ala5Val Uncertain significance Single submitter
- ABCG4 p.Arg502His Uncertain significance Single submitter
- ABCG4 p.Arg94Cys Uncertain significance Single submitter
- ABCG4 p.Arg94His Uncertain significance Single submitter
- ABCG4 p.Arg94Leu Uncertain significance Single submitter
- ABCG4 p.Arg95Gln Uncertain significance Single submitter
- ABCG4 p.Glu311Lys Uncertain significance Single submitter
- ABCG4 p.Glu346Lys Uncertain significance Single submitter
- ABCG4 p.Gly249Trp Uncertain significance Single submitter
- ABCG4 p.Gly425Ser Uncertain significance Single submitter
- ABCG4 p.Gly525Arg Uncertain significance Single submitter
- ABCG4 p.Ile361Thr Uncertain significance Single submitter
- ABCG4 p.Leu264Phe Uncertain significance Single submitter
- ABCG4 p.Leu383Pro Uncertain significance Single submitter
- ABCG4 p.Leu6Val Uncertain significance Single submitter
- ABCG4 p.Met454Leu Uncertain significance Single submitter
- ABCG4 p.Met618Thr Uncertain significance Single submitter
- ABCG4 p.Phe396Leu Uncertain significance Single submitter
- ABCG4 p.Pro300Arg Uncertain significance Single submitter
- ABCG4 p.Pro483Leu Uncertain significance Single submitter
- ABCG4 p.Thr23Lys Uncertain significance Single submitter
- ABCG4 p.Thr34Ile Uncertain significance Single submitter
- ABCG4 p.Thr35Ala Uncertain significance Single submitter
- ABCG4 p.Thr511Ile Uncertain significance Single submitter
- ABCG4 p.Thr541Ile Uncertain significance Single submitter
- ABCG4 p.Tyr291His Uncertain significance Single submitter
- ABCG4 p.Val22Leu Uncertain significance Single submitter
- ABCG4 p.Val347Ile Uncertain significance Single submitter
- ABCG4 p.Val404Met Uncertain significance Single submitter
- ABCG4 p.Val578Met Uncertain significance Single submitter
-
ABCG4 p.Arg79Ser
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 18
The independent predictors disagree with each other — read with care.
- ABCG4 p.Ala470Gly Uncertain significance Single submitter
- ABCG4 p.Arg600Gln Likely benign Single submitter
- ABCG4 p.Arg641Gln Uncertain significance Single submitter
- ABCG4 p.Arg641Trp Uncertain significance Single submitter
- ABCG4 p.Glu62Asp Uncertain significance Single submitter
- ABCG4 p.Gly189Ser Uncertain significance Single submitter
- ABCG4 p.Ile253Met Uncertain significance Single submitter
- ABCG4 p.Ile402Thr Uncertain significance Single submitter
- ABCG4 p.Met222Val Uncertain significance Single submitter
- ABCG4 p.Phe453Leu Uncertain significance Single submitter
- ABCG4 p.Pro154Leu Uncertain significance Single submitter
- ABCG4 p.Ser554Gly Uncertain significance Single submitter
- ABCG4 p.Thr389Met Uncertain significance Single submitter
- ABCG4 p.Val164Phe Uncertain significance Single submitter
- ABCG4 p.Val240Ala Uncertain significance Single submitter
- ABCG4 p.Val452Ile Uncertain significance Single submitter
- ABCG4 p.Val490Met Uncertain significance Single submitter
- ABCG4 p.Val571Ile Uncertain significance Single submitter
All ABCG4 variants
Benign 3
- p.Asn345= Multiple submitters
- p.Lys178= Multiple submitters
- p.Pro352Leu Multiple submitters
Likely benign 4
- p.Ala334Thr Single submitter
- p.Arg600Gln Single submitter ⚠
- p.Asp415Asn Single submitter
- p.Val284Met Single submitter
Uncertain significance 54
- p.Ala17Pro Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Ala19Val Single submitter ⚠
- p.Ala212Thr Single submitter ⚠
- p.Ala234Ser Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala470Gly Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Arg502His Single submitter ⚠
- p.Arg641Gln Single submitter ⚠
- p.Arg641Trp Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Arg94Leu Single submitter ⚠
- p.Arg95Gln Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu346Lys Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.Gly189Ser Single submitter ⚠
- p.Gly249Trp Single submitter ⚠
- p.Gly425Ser Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.Ile253Met Single submitter ⚠
- p.Ile361Thr Single submitter ⚠
- p.Ile402Thr Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu383Pro Single submitter ⚠
- p.Leu6Val Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Met454Leu Single submitter ⚠
- p.Met618Thr Single submitter ⚠
- p.Phe396Leu Single submitter ⚠
- p.Phe453Leu Single submitter ⚠
- p.Pro154Leu Single submitter ⚠
- p.Pro300Arg Single submitter ⚠
- p.Pro483Leu Single submitter ⚠
- p.Ser554Gly Single submitter ⚠
- p.Thr23Lys Single submitter ⚠
- p.Thr34Ile Single submitter ⚠
- p.Thr35Ala Single submitter ⚠
- p.Thr389Met Single submitter ⚠
- p.Thr511Ile Single submitter ⚠
- p.Thr541Ile Single submitter ⚠
- p.Tyr291His Single submitter ⚠
- p.Val164Phe Single submitter ⚠
- p.Val22Leu Single submitter ⚠
- p.Val240Ala Single submitter ⚠
- p.Val347Ile Single submitter ⚠
- p.Val404Met Single submitter ⚠
- p.Val452Ile Single submitter ⚠
- p.Val490Met Single submitter ⚠
- p.Val571Ile Single submitter ⚠
- p.Val578Met Single submitter ⚠
- p.Arg79Ser No assertion criteria prostate cancer ⚠