ABHD10 — 54 ClinVar variants
All ClinVar germline ABHD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Likely benign · 50 Uncertain significance
Full ABHD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABHD10 p.Ala106Gly Uncertain significance Single submitter
- ABHD10 p.Ala48Val Uncertain significance Single submitter
- ABHD10 p.Arg165Leu Uncertain significance Single submitter
- ABHD10 p.Arg44Gln Uncertain significance Single submitter
- ABHD10 p.Asn65Lys Uncertain significance Single submitter
- ABHD10 p.Gly150Glu Uncertain significance Single submitter
- ABHD10 p.Gly26Cys Uncertain significance Single submitter
- ABHD10 p.His227Arg Uncertain significance Single submitter
- ABHD10 p.Ile163Val Uncertain significance Single submitter
- ABHD10 p.Ile251Thr Uncertain significance Single submitter
- ABHD10 p.Ile38Met Uncertain significance Single submitter
- ABHD10 p.Ile81Thr Uncertain significance Single submitter
- ABHD10 p.Leu231Ser Uncertain significance Single submitter
- ABHD10 p.Met199Ile Uncertain significance Single submitter
- ABHD10 p.Met199Thr Uncertain significance Single submitter
- ABHD10 p.Met88Ile Uncertain significance Single submitter
- ABHD10 p.Pro27Ser Uncertain significance Single submitter
- ABHD10 p.Thr177Ile Uncertain significance Single submitter
- ABHD10 p.Thr91Ala Uncertain significance Single submitter
- ABHD10 p.Trp20Cys Uncertain significance Single submitter
- ABHD10 p.Trp45Cys Uncertain significance Single submitter
- ABHD10 p.Val252Ala Uncertain significance Single submitter
- ABHD10 p.Val9Leu Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- ABHD10 p.Ala10Val Uncertain significance Single submitter
- ABHD10 p.Ala11Asp Uncertain significance Single submitter
- ABHD10 p.Arg37Trp Uncertain significance Single submitter
- ABHD10 p.Asn187Asp Uncertain significance Single submitter
- ABHD10 p.Asp250Asn Uncertain significance Single submitter
- ABHD10 p.Asp262Asn Uncertain significance Single submitter
- ABHD10 p.Asp278Val Uncertain significance Single submitter
- ABHD10 p.Glu192Gly Uncertain significance Single submitter
- ABHD10 p.Glu226Gly Uncertain significance Single submitter
- ABHD10 p.Gly120Asp Uncertain significance Single submitter
- ABHD10 p.Gly246Ala Uncertain significance Single submitter
- ABHD10 p.His160Tyr Uncertain significance Single submitter
- ABHD10 p.Ile108Met Uncertain significance Single submitter
- ABHD10 p.Ile108Val Uncertain significance Single submitter
- ABHD10 p.Ile138Thr Uncertain significance Single submitter
- ABHD10 p.Ile173Thr Uncertain significance Single submitter
- ABHD10 p.Ile298Thr Uncertain significance Single submitter
- ABHD10 p.Leu172Val Uncertain significance Single submitter
- ABHD10 p.Leu6Ser Uncertain significance Single submitter
- ABHD10 p.Lys195Met Uncertain significance Single submitter
- ABHD10 p.Met88Thr Uncertain significance Single submitter
- ABHD10 p.Pro47Arg Uncertain significance Single submitter
- ABHD10 p.Ser125Arg Uncertain significance Single submitter
- ABHD10 p.Thr184Lys Uncertain significance Single submitter
- ABHD10 p.Thr293Ala Uncertain significance Single submitter
- ABHD10 p.Val170Met Likely benign Single submitter
- ABHD10 p.Val269Met Uncertain significance Single submitter
- ABHD10 p.Val33Met Uncertain significance Single submitter
All ABHD10 variants
Likely benign 4
- p.Leu193Val Single submitter
- p.Ser17Arg Single submitter
- p.Val170Met Single submitter ⚠
- p.Val175Ile Single submitter
Uncertain significance 50
- p.Ala106Gly Single submitter ⚠
- p.Ala10Val Single submitter ⚠
- p.Ala11Asp Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Arg165Leu Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Asn187Asp Single submitter ⚠
- p.Asn65Lys Single submitter ⚠
- p.Asp250Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp278Val Single submitter ⚠
- p.Glu192Gly Single submitter ⚠
- p.Glu226Gly Single submitter ⚠
- p.Gly120Asp Single submitter ⚠
- p.Gly150Glu Single submitter ⚠
- p.Gly246Ala Single submitter ⚠
- p.Gly26Cys Single submitter ⚠
- p.His160Tyr Single submitter ⚠
- p.His227Arg Single submitter ⚠
- p.Ile108Met Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile138Thr Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile173Thr Single submitter ⚠
- p.Ile251Thr Single submitter ⚠
- p.Ile298Thr Single submitter ⚠
- p.Ile38Met Single submitter ⚠
- p.Ile81Thr Single submitter ⚠
- p.Leu172Val Single submitter ⚠
- p.Leu231Ser Single submitter ⚠
- p.Leu6Ser Single submitter ⚠
- p.Lys195Met Single submitter ⚠
- p.Met199Ile Single submitter ⚠
- p.Met199Thr Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Met88Thr Single submitter ⚠
- p.Pro27Ser Single submitter ⚠
- p.Pro47Arg Single submitter ⚠
- p.Ser125Arg Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr184Lys Single submitter ⚠
- p.Thr293Ala Single submitter ⚠
- p.Thr91Ala Single submitter ⚠
- p.Trp20Cys Single submitter ⚠
- p.Trp45Cys Single submitter ⚠
- p.Val252Ala Single submitter ⚠
- p.Val269Met Single submitter ⚠
- p.Val33Met Single submitter ⚠
- p.Val9Leu Single submitter ⚠