ABL2 — 120 ClinVar variants
All ClinVar germline ABL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 114 flagged for review →
2 Benign · 2 Likely benign · 116 Uncertain significance
Full ABL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 114
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABL2 p.Ala1029Thr Uncertain significance Single submitter
- ABL2 p.Ala1076Thr Uncertain significance Single submitter
- ABL2 p.Ala38Ser Uncertain significance Single submitter
- ABL2 p.Ala445Thr Uncertain significance Single submitter
- ABL2 p.Ala622Thr Uncertain significance Single submitter
- ABL2 p.Ala710Val Uncertain significance Single submitter
- ABL2 p.Ala765Thr Uncertain significance Single submitter
- ABL2 p.Ala857Thr Uncertain significance Single submitter
- ABL2 p.Ala88Thr Uncertain significance Single submitter
- ABL2 p.Arg34Thr Uncertain significance Single submitter
- ABL2 p.Arg40Leu Uncertain significance Single submitter
- ABL2 p.Arg580Gln Uncertain significance Single submitter
- ABL2 p.Arg660Lys Uncertain significance Single submitter
- ABL2 p.Arg78Cys Uncertain significance Single submitter
- ABL2 p.Arg974Gln Uncertain significance Single submitter
- ABL2 p.Asn1060Ser Uncertain significance Single submitter
- ABL2 p.Asn1106Ser Uncertain significance Single submitter
- ABL2 p.Asn192Ser Uncertain significance Single submitter
- ABL2 p.Asn377Ser Uncertain significance Single submitter
- ABL2 p.Asn460Ser Uncertain significance Single submitter
- ABL2 p.Asn830Ser Uncertain significance Single submitter
- ABL2 p.Asp971Ala Uncertain significance Single submitter
- ABL2 p.Cys82Phe Uncertain significance Single submitter
- ABL2 p.Gln1013Arg Uncertain significance Single submitter
- ABL2 p.Gln1148Arg Uncertain significance Single submitter
- ABL2 p.Gln15His Uncertain significance Single submitter
- ABL2 p.Gln87Lys Uncertain significance Single submitter
- ABL2 p.Gln965His Uncertain significance Single submitter
- ABL2 p.Glu1087Asp Uncertain significance Single submitter
- ABL2 p.Glu338Gly Uncertain significance Single submitter
- ABL2 p.Gly122Asp Uncertain significance Single submitter
- ABL2 p.Gly193Val Uncertain significance Single submitter
- ABL2 p.Gly297Ser Uncertain significance Single submitter
- ABL2 p.Gly613Arg Uncertain significance Single submitter
- ABL2 p.Gly613Asp Uncertain significance Single submitter
- ABL2 p.Gly742Ala Uncertain significance Single submitter
- ABL2 p.Gly895Ser Uncertain significance Single submitter
- ABL2 p.Gly908Arg Uncertain significance Single submitter
- ABL2 p.Gly912Arg Uncertain significance Single submitter
- ABL2 p.His680Tyr Uncertain significance Single submitter
- ABL2 p.His927Gln Uncertain significance Single submitter
- ABL2 p.Ile574Thr Uncertain significance Single submitter
- ABL2 p.Ile871Val Uncertain significance Single submitter
- ABL2 p.Leu1095Ile Uncertain significance Single submitter
- ABL2 p.Leu852Ile Uncertain significance Single submitter
- ABL2 p.Leu992Val Uncertain significance Single submitter
- ABL2 p.Lys1057Arg Uncertain significance Single submitter
- ABL2 p.Lys280Gln Uncertain significance Single submitter
- ABL2 p.Lys293Arg Uncertain significance Single submitter
- ABL2 p.Met389Val Uncertain significance Single submitter
- ABL2 p.Met787Val Uncertain significance Single submitter
- ABL2 p.Met797Val Uncertain significance Single submitter
- ABL2 p.Met799Val Uncertain significance Single submitter
- ABL2 p.Met990Ile Uncertain significance Single submitter
- ABL2 p.Phe701Leu Uncertain significance Single submitter
- ABL2 p.Pro1047Ala Uncertain significance Single submitter
- ABL2 p.Pro1164Ala Uncertain significance Single submitter
- ABL2 p.Pro12Ser Uncertain significance Single submitter
- ABL2 p.Pro204Thr Uncertain significance Single submitter
- ABL2 p.Pro30Ser Uncertain significance Single submitter
- ABL2 p.Pro448Leu Uncertain significance Single submitter
- ABL2 p.Pro792Arg Uncertain significance Single submitter
- ABL2 p.Pro792Leu Uncertain significance Single submitter
- ABL2 p.Pro854Ala Uncertain significance Single submitter
- ABL2 p.Pro905Thr Uncertain significance Single submitter
- ABL2 p.Pro911Leu Uncertain significance Single submitter
- ABL2 p.Ser1033Arg Uncertain significance Single submitter
- ABL2 p.Ser1054Leu Uncertain significance Single submitter
- ABL2 p.Ser1097Thr Uncertain significance Single submitter
- ABL2 p.Ser210Leu Uncertain significance Single submitter
-
ABL2 p.Ser249Phe
Uncertain significance
Single submitter
Inborn genetic diseases
- ABL2 p.Ser634Gly Uncertain significance Single submitter
- ABL2 p.Ser789Ala Uncertain significance Single submitter
- ABL2 p.Ser962Pro Uncertain significance Single submitter
- ABL2 p.Thr1007Ala Uncertain significance Single submitter
- ABL2 p.Thr1101Ala Uncertain significance Single submitter
- ABL2 p.Thr42Lys Uncertain significance Single submitter
- ABL2 p.Thr664Ser Uncertain significance Single submitter
- ABL2 p.Thr686Met Uncertain significance Single submitter
- ABL2 p.Tyr495Cys Uncertain significance Single submitter
- ABL2 p.Tyr718Cys Uncertain significance Single submitter
- ABL2 p.Tyr80Cys Uncertain significance Single submitter
- ABL2 p.Val1124Glu Uncertain significance Single submitter
- ABL2 p.Val306Ile Uncertain significance Single submitter
- ABL2 p.Val966Ala Uncertain significance Single submitter
-
ABL2 p.Thr664Ile
Uncertain significance
No assertion criteria
ABL2-related condition
Predictors split 28
The independent predictors disagree with each other — read with care.
- ABL2 p.Ala1156Val Uncertain significance Single submitter
- ABL2 p.Arg1131Cys Uncertain significance Single submitter
- ABL2 p.Arg237Cys Uncertain significance Single submitter
- ABL2 p.Asp528Asn Uncertain significance Single submitter
- ABL2 p.Glu379Ala Uncertain significance Single submitter
- ABL2 p.Gly103Arg Uncertain significance Single submitter
- ABL2 p.Gly13Trp Uncertain significance Single submitter
- ABL2 p.Gly39Trp Uncertain significance Single submitter
- ABL2 p.Gly735Cys Uncertain significance Single submitter
- ABL2 p.Gly737Val Uncertain significance Single submitter
- ABL2 p.Gly742Arg Uncertain significance Single submitter
- ABL2 p.Lys716Asn Uncertain significance Single submitter
- ABL2 p.Met483Leu Uncertain significance Single submitter
- ABL2 p.Pro342Arg Uncertain significance Single submitter
- ABL2 p.Ser236Asn Uncertain significance Single submitter
- ABL2 p.Ser456Cys Uncertain significance Single submitter
- ABL2 p.Ser525Thr Uncertain significance Single submitter
- ABL2 p.Ser531Cys Uncertain significance Single submitter
- ABL2 p.Ser602Cys Uncertain significance Single submitter
- ABL2 p.Ser605Ile Uncertain significance Single submitter
- ABL2 p.Ser786Pro Uncertain significance Single submitter
- ABL2 p.Ser817Pro Uncertain significance Single submitter
- ABL2 p.Ser820Thr Uncertain significance Single submitter
- ABL2 p.Ser936Leu Uncertain significance Single submitter
- ABL2 p.Ser969Phe Uncertain significance Single submitter
- ABL2 p.Thr1007Ile Uncertain significance Single submitter
- ABL2 p.Val165Met Uncertain significance Single submitter
- ABL2 p.Val884Met Uncertain significance Single submitter
All ABL2 variants
Benign 2
- c.*4125A>G Multiple submitters
- p.Lys930Arg Multiple submitters
Likely benign 2
- p.Thr784Ser Multiple submitters
- p.Ser466= Single submitter
Uncertain significance 116
- p.Ala1029Thr Single submitter ⚠
- p.Ala1076Thr Single submitter ⚠
- p.Ala1156Val Single submitter ⚠
- p.Ala38Ser Single submitter ⚠
- p.Ala445Thr Single submitter ⚠
- p.Ala622Thr Single submitter ⚠
- p.Ala710Val Single submitter ⚠
- p.Ala765Thr Single submitter ⚠
- p.Ala857Thr Single submitter ⚠
- p.Ala88Thr Single submitter ⚠
- p.Arg1131Cys Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg34Thr Single submitter ⚠
- p.Arg40Leu Single submitter ⚠
- p.Arg580Gln Single submitter ⚠
- p.Arg660Lys Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Arg974Gln Single submitter ⚠
- p.Asn1060Ser Single submitter ⚠
- p.Asn1106Ser Single submitter ⚠
- p.Asn192Ser Single submitter ⚠
- p.Asn377Ser Single submitter ⚠
- p.Asn460Ser Single submitter ⚠
- p.Asn830Ser Single submitter ⚠
- p.Asp528Asn Single submitter ⚠
- p.Asp971Ala Single submitter ⚠
- p.Cys82Phe Single submitter ⚠
- p.Gln1013Arg Single submitter ⚠
- p.Gln1148Arg Single submitter ⚠
- p.Gln15His Single submitter ⚠
- p.Gln15Ter Single submitter Inborn genetic diseases
- p.Gln87Lys Single submitter ⚠
- p.Gln965His Single submitter ⚠
- p.Glu1087Asp Single submitter ⚠
- p.Glu338Gly Single submitter ⚠
- p.Glu379Ala Single submitter ⚠
- p.Gly103Arg Single submitter ⚠
- p.Gly122Asp Single submitter ⚠
- p.Gly13Trp Single submitter ⚠
- p.Gly193Val Single submitter ⚠
- p.Gly297Ser Single submitter ⚠
- p.Gly39Trp Single submitter ⚠
- p.Gly613Arg Single submitter ⚠
- p.Gly613Asp Single submitter ⚠
- p.Gly735Cys Single submitter ⚠
- p.Gly737Val Single submitter ⚠
- p.Gly742Ala Single submitter ⚠
- p.Gly742Arg Single submitter ⚠
- p.Gly895Ser Single submitter ⚠
- p.Gly908Arg Single submitter ⚠
- p.Gly912Arg Single submitter ⚠
- p.His680Tyr Single submitter ⚠
- p.His927Gln Single submitter ⚠
- p.Ile574Thr Single submitter ⚠
- p.Ile871Val Single submitter ⚠
- p.Leu1095Ile Single submitter ⚠
- p.Leu852Ile Single submitter ⚠
- p.Leu992Val Single submitter ⚠
- p.Lys1057Arg Single submitter ⚠
- p.Lys280Gln Single submitter ⚠
- p.Lys293Arg Single submitter ⚠
- p.Lys716Asn Single submitter ⚠
- p.Met389Val Single submitter ⚠
- p.Met483Leu Single submitter ⚠
- p.Met787Val Single submitter ⚠
- p.Met797Val Single submitter ⚠
- p.Met799Val Single submitter ⚠
- p.Met990Ile Single submitter ⚠
- p.Phe701Leu Single submitter ⚠
- p.Pro1047Ala Single submitter ⚠
- p.Pro1164Ala Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro204Thr Single submitter ⚠
- p.Pro30Ser Single submitter ⚠
- p.Pro342Arg Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Pro792Arg Single submitter ⚠
- p.Pro792Leu Single submitter ⚠
- p.Pro854Ala Single submitter ⚠
- p.Pro905Thr Single submitter ⚠
- p.Pro911Leu Single submitter ⚠
- p.Ser1033Arg Single submitter ⚠
- p.Ser1054Leu Single submitter ⚠
- p.Ser1097Thr Single submitter ⚠
- p.Ser210Leu Single submitter ⚠
- p.Ser236Asn Single submitter ⚠
- p.Ser249Phe Single submitter Inborn genetic diseases ⚠
- p.Ser456Cys Single submitter ⚠
- p.Ser525Thr Single submitter ⚠
- p.Ser531Cys Single submitter ⚠
- p.Ser602Cys Single submitter ⚠
- p.Ser605Ile Single submitter ⚠
- p.Ser634Gly Single submitter ⚠
- p.Ser786Pro Single submitter ⚠
- p.Ser789Ala Single submitter ⚠
- p.Ser817Pro Single submitter ⚠
- p.Ser820Thr Single submitter ⚠
- p.Ser936Leu Single submitter ⚠
- p.Ser962Pro Single submitter ⚠
- p.Ser969Phe Single submitter ⚠
- p.Thr1007Ala Single submitter ⚠
- p.Thr1007Ile Single submitter ⚠
- p.Thr1101Ala Single submitter ⚠
- p.Thr42Lys Single submitter ⚠
- p.Thr664Ser Single submitter ⚠
- p.Thr686Met Single submitter ⚠
- p.Tyr495Cys Single submitter ⚠
- p.Tyr718Cys Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Val1124Glu Single submitter ⚠
- p.Val165Met Single submitter ⚠
- p.Val306Ile Single submitter ⚠
- p.Val884Met Single submitter ⚠
- p.Val966Ala Single submitter ⚠
- p.Leu695= No assertion criteria
- p.Thr664Ile No assertion criteria ABL2-related condition ⚠