ABLIM2 — 130 ClinVar variants
All ClinVar germline ABLIM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →
2 Benign · 7 Likely benign · 121 Uncertain significance
Full ABLIM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 120
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABLIM2 p.Ala144Thr Uncertain significance Single submitter
- ABLIM2 p.Ala288Val Uncertain significance Single submitter
- ABLIM2 p.Ala476Ser Uncertain significance Single submitter
- ABLIM2 p.Ala565Asp Uncertain significance Single submitter
- ABLIM2 p.Ala97Val Uncertain significance Single submitter
- ABLIM2 p.Arg327Cys Uncertain significance Single submitter
- ABLIM2 p.Arg355Gln Uncertain significance Single submitter
- ABLIM2 p.Arg37Gln Uncertain significance Single submitter
- ABLIM2 p.Arg560Gln Uncertain significance Single submitter
- ABLIM2 p.Arg595His Uncertain significance Single submitter
- ABLIM2 p.Arg629Leu Uncertain significance Single submitter
- ABLIM2 p.Asn273Asp Uncertain significance Single submitter
- ABLIM2 p.Asn561Ser Uncertain significance Single submitter
- ABLIM2 p.Asn563His Uncertain significance Single submitter
- ABLIM2 p.Asn563Ser Uncertain significance Single submitter
- ABLIM2 p.Asp105Asn Uncertain significance Single submitter
- ABLIM2 p.Asp343Tyr Uncertain significance Single submitter
- ABLIM2 p.Asp512Val Uncertain significance Single submitter
- ABLIM2 p.Asp527Glu Uncertain significance Single submitter
- ABLIM2 p.Asp570Glu Uncertain significance Single submitter
- ABLIM2 p.Asp74Glu Uncertain significance Single submitter
- ABLIM2 p.Cys153Tyr Uncertain significance Single submitter
- ABLIM2 p.Cys212Tyr Uncertain significance Single submitter
- ABLIM2 p.Gln447His Uncertain significance Single submitter
- ABLIM2 p.Glu190Lys Uncertain significance Single submitter
- ABLIM2 p.Glu349Lys Uncertain significance Single submitter
- ABLIM2 p.Glu34Lys Uncertain significance Single submitter
- ABLIM2 p.Glu482Asp Uncertain significance Single submitter
- ABLIM2 p.Glu59Lys Uncertain significance Single submitter
- ABLIM2 p.Gly119Arg Uncertain significance Single submitter
- ABLIM2 p.Gly149Ser Uncertain significance Single submitter
- ABLIM2 p.Gly209Ser Uncertain significance Single submitter
- ABLIM2 p.Gly568Glu Uncertain significance Single submitter
- ABLIM2 p.Gly61Ser Uncertain significance Single submitter
- ABLIM2 p.Gly80Ser Uncertain significance Single submitter
- ABLIM2 p.Gly99Arg Uncertain significance Single submitter
- ABLIM2 p.His145Pro Uncertain significance Single submitter
- ABLIM2 p.Ile192Asn Uncertain significance Single submitter
- ABLIM2 p.Ile70Thr Uncertain significance Single submitter
- ABLIM2 p.Leu638Pro Uncertain significance Single submitter
- ABLIM2 p.Lys171Arg Uncertain significance Single submitter
- ABLIM2 p.Met251Ile Uncertain significance Single submitter
- ABLIM2 p.Phe116Leu Uncertain significance Single submitter
- ABLIM2 p.Phe116Val Uncertain significance Single submitter
- ABLIM2 p.Phe245Ile Uncertain significance Single submitter
- ABLIM2 p.Pro118His Uncertain significance Single submitter
- ABLIM2 p.Pro13Arg Uncertain significance Single submitter
- ABLIM2 p.Pro233Ser Uncertain significance Single submitter
- ABLIM2 p.Pro295Leu Uncertain significance Single submitter
- ABLIM2 p.Pro317Arg Uncertain significance Single submitter
- ABLIM2 p.Pro441Leu Uncertain significance Single submitter
- ABLIM2 p.Pro450Ser Uncertain significance Single submitter
- ABLIM2 p.Pro456Ala Uncertain significance Single submitter
- ABLIM2 p.Ser439Asn Uncertain significance Single submitter
- ABLIM2 p.Ser5Leu Uncertain significance Single submitter
- ABLIM2 p.Ser96Leu Uncertain significance Single submitter
- ABLIM2 p.Thr20Met Uncertain significance Single submitter
- ABLIM2 p.Thr458Ala Uncertain significance Single submitter
- ABLIM2 p.Thr506Ala Uncertain significance Single submitter
- ABLIM2 p.Tyr102Cys Uncertain significance Single submitter
- ABLIM2 p.Tyr231His Uncertain significance Single submitter
- ABLIM2 p.Val111Ile Uncertain significance Single submitter
- ABLIM2 p.Val138Leu Uncertain significance Single submitter
- ABLIM2 p.Val167Leu Uncertain significance Single submitter
- ABLIM2 p.Val223Met Uncertain significance Single submitter
- ABLIM2 p.Val38Met Uncertain significance Single submitter
- ABLIM2 p.Val455Ile Uncertain significance Single submitter
- ABLIM2 p.Val455Phe Uncertain significance Single submitter
- ABLIM2 p.Val460Ile Uncertain significance Single submitter
- ABLIM2 p.Val602Met Uncertain significance Single submitter
Predictors split 50
The independent predictors disagree with each other — read with care.
- ABLIM2 p.Ala206Thr Likely benign Single submitter
- ABLIM2 p.Ala21Val Uncertain significance Single submitter
- ABLIM2 p.Arg211Cys Uncertain significance Single submitter
- ABLIM2 p.Arg211His Uncertain significance Single submitter
- ABLIM2 p.Arg361Gln Uncertain significance Single submitter
- ABLIM2 p.Arg361Trp Uncertain significance Single submitter
- ABLIM2 p.Arg375His Uncertain significance Single submitter
- ABLIM2 p.Arg388His Uncertain significance Single submitter
- ABLIM2 p.Arg428Trp Uncertain significance Single submitter
- ABLIM2 p.Arg451Cys Uncertain significance Single submitter
- ABLIM2 p.Arg593Gln Uncertain significance Single submitter
- ABLIM2 p.Arg595Cys Uncertain significance Single submitter
- ABLIM2 p.Arg595Gly Uncertain significance Single submitter
- ABLIM2 p.Arg595Leu Uncertain significance Single submitter
- ABLIM2 p.Arg65Gln Uncertain significance Single submitter
- ABLIM2 p.Asp586Val Uncertain significance Single submitter
- ABLIM2 p.Gln164Glu Uncertain significance Single submitter
- ABLIM2 p.Glu625Gln Uncertain significance Single submitter
- ABLIM2 p.Glu625Lys Uncertain significance Single submitter
- ABLIM2 p.Glu626Gln Uncertain significance Single submitter
- ABLIM2 p.Gly157Ser Uncertain significance Single submitter
- ABLIM2 p.Gly163Ser Uncertain significance Single submitter
- ABLIM2 p.Gly176Val Uncertain significance Single submitter
- ABLIM2 p.Gly242Ser Uncertain significance Single submitter
- ABLIM2 p.Gly293Val Uncertain significance Single submitter
- ABLIM2 p.Gly427Asp Uncertain significance Single submitter
- ABLIM2 p.Ile258Met Uncertain significance Single submitter
- ABLIM2 p.Ile582Met Uncertain significance Single submitter
- ABLIM2 p.Leu197Gln Uncertain significance Single submitter
- ABLIM2 p.Lys194Gln Uncertain significance Single submitter
- ABLIM2 p.Lys41Arg Uncertain significance Single submitter
- ABLIM2 p.Met244Ile Uncertain significance Single submitter
- ABLIM2 p.Phe84Val Uncertain significance Single submitter
- ABLIM2 p.Pro13Leu Uncertain significance Single submitter
- ABLIM2 p.Pro613Ser Uncertain significance Single submitter
- ABLIM2 p.Ser139Leu Uncertain significance Single submitter
- ABLIM2 p.Ser142Arg Uncertain significance Single submitter
- ABLIM2 p.Ser17Leu Uncertain significance Single submitter
- ABLIM2 p.Ser424Asn Uncertain significance Single submitter
- ABLIM2 p.Ser623Arg Uncertain significance Single submitter
- ABLIM2 p.Thr26Met Uncertain significance Single submitter
- ABLIM2 p.Thr605Met Uncertain significance Single submitter
- ABLIM2 p.Val108Met Uncertain significance Single submitter
- ABLIM2 p.Val111Gly Uncertain significance Single submitter
- ABLIM2 p.Val138Ile Uncertain significance Single submitter
- ABLIM2 p.Val140Met Likely benign Single submitter
- ABLIM2 p.Val435Met Uncertain significance Single submitter
- ABLIM2 p.Val590Ile Uncertain significance Single submitter
- ABLIM2 p.Val596Ala Uncertain significance Single submitter
- ABLIM2 p.Val619Ala Uncertain significance Single submitter
All ABLIM2 variants
Benign 2
- c.763+4C>T Multiple submitters
- c.763+5A>G Multiple submitters
Likely benign 7
- p.Ala206Thr Single submitter ⚠
- p.Ala226= Single submitter
- p.Cys215= Single submitter
- p.Leu98= Single submitter
- p.Met130Val Single submitter
- p.Met577Thr Single submitter
- p.Val140Met Single submitter ⚠
Uncertain significance 121
- p.Ala144Thr Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala476Ser Single submitter ⚠
- p.Ala565Asp Single submitter ⚠
- p.Ala97Val Single submitter ⚠
- p.Arg211Cys Single submitter ⚠
- p.Arg211His Single submitter ⚠
- p.Arg327Cys Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg361Gln Single submitter ⚠
- p.Arg361Trp Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg428Trp Single submitter ⚠
- p.Arg451Cys Single submitter ⚠
- p.Arg560Gln Single submitter ⚠
- p.Arg593Gln Single submitter ⚠
- p.Arg595Cys Single submitter ⚠
- p.Arg595Gly Single submitter ⚠
- p.Arg595His Single submitter ⚠
- p.Arg595Leu Single submitter ⚠
- p.Arg629Leu Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Asn273Asp Single submitter ⚠
- p.Asn561Ser Single submitter ⚠
- p.Asn563His Single submitter ⚠
- p.Asn563Ser Single submitter ⚠
- p.Asp105Asn Single submitter ⚠
- p.Asp343Tyr Single submitter ⚠
- p.Asp512Val Single submitter ⚠
- p.Asp527Glu Single submitter ⚠
- p.Asp570Glu Single submitter ⚠
- p.Asp586Val Single submitter ⚠
- p.Asp74Glu Single submitter ⚠
- p.Cys153Tyr Single submitter ⚠
- p.Cys212Tyr Single submitter ⚠
- p.Gln164Glu Single submitter ⚠
- p.Gln447His Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu482Asp Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Glu625Gln Single submitter ⚠
- p.Glu625Lys Single submitter ⚠
- p.Glu626Gln Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly163Ser Single submitter ⚠
- p.Gly176Val Single submitter ⚠
- p.Gly209Ser Single submitter ⚠
- p.Gly242Ser Single submitter ⚠
- p.Gly293Val Single submitter ⚠
- p.Gly427Asp Single submitter ⚠
- p.Gly568Glu Single submitter ⚠
- p.Gly61Ser Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His145Pro Single submitter ⚠
- p.Ile192Asn Single submitter ⚠
- p.Ile258Met Single submitter ⚠
- p.Ile582Met Single submitter ⚠
- p.Ile70Thr Single submitter ⚠
- p.Leu197Gln Single submitter ⚠
- p.Leu638Pro Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys194Gln Single submitter ⚠
- p.Lys41Arg Single submitter ⚠
- p.Met244Ile Single submitter ⚠
- p.Met251Ile Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Phe116Val Single submitter ⚠
- p.Phe245Ile Single submitter ⚠
- p.Phe84Val Single submitter ⚠
- p.Pro118His Single submitter ⚠
- p.Pro13Arg Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro233Ser Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro317Arg Single submitter ⚠
- p.Pro441Leu Single submitter ⚠
- p.Pro450Ser Single submitter ⚠
- p.Pro456Ala Single submitter ⚠
- p.Pro613Ser Single submitter ⚠
- p.Ser139Leu Single submitter ⚠
- p.Ser142Arg Single submitter ⚠
- p.Ser17Leu Single submitter ⚠
- p.Ser394Asn Single submitter
- p.Ser398Asn Single submitter
- p.Ser424Asn Single submitter ⚠
- p.Ser439Asn Single submitter ⚠
- p.Ser5Leu Single submitter ⚠
- p.Ser623Arg Single submitter ⚠
- p.Ser96Leu Single submitter ⚠
- p.Thr20Met Single submitter ⚠
- p.Thr26Met Single submitter ⚠
- p.Thr458Ala Single submitter ⚠
- p.Thr506Ala Single submitter ⚠
- p.Thr605Met Single submitter ⚠
- p.Tyr102Cys Single submitter ⚠
- p.Tyr231His Single submitter ⚠
- p.Val108Met Single submitter ⚠
- p.Val111Gly Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val138Leu Single submitter ⚠
- p.Val167Leu Single submitter ⚠
- p.Val223Met Single submitter ⚠
- p.Val38Met Single submitter ⚠
- p.Val412Ala Single submitter
- p.Val435Met Single submitter ⚠
- p.Val455Ile Single submitter ⚠
- p.Val455Phe Single submitter ⚠
- p.Val460Ile Single submitter ⚠
- p.Val590Ile Single submitter ⚠
- p.Val596Ala Single submitter ⚠
- p.Val602Met Single submitter ⚠
- p.Val619Ala Single submitter ⚠