ABLIM3 — 124 ClinVar variants
All ClinVar germline ABLIM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 119 flagged for review →
3 Benign · 121 Uncertain significance
Full ABLIM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 119
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ABLIM3 p.Ala166Gly Uncertain significance Single submitter
- ABLIM3 p.Ala371Asp Uncertain significance Single submitter
- ABLIM3 p.Ala600Pro Uncertain significance Single submitter
- ABLIM3 p.Arg238Cys Uncertain significance Single submitter
- ABLIM3 p.Arg25Cys Uncertain significance Single submitter
- ABLIM3 p.Arg266Trp Uncertain significance Single submitter
- ABLIM3 p.Arg36His Uncertain significance Single submitter
- ABLIM3 p.Arg513His Uncertain significance Single submitter
- ABLIM3 p.Arg596Gly Uncertain significance Single submitter
- ABLIM3 p.Arg86Gln Uncertain significance Single submitter
- ABLIM3 p.Arg99Cys Uncertain significance Single submitter
- ABLIM3 p.Asp338Asn Uncertain significance Single submitter
- ABLIM3 p.Asp509Glu Uncertain significance Single submitter
- ABLIM3 p.Asp512Glu Uncertain significance Single submitter
- ABLIM3 p.Asp606Asn Uncertain significance Single submitter
- ABLIM3 p.Cys261Tyr Uncertain significance Single submitter
- ABLIM3 p.Cys54Tyr Uncertain significance Single submitter
- ABLIM3 p.Glu223Lys Uncertain significance Single submitter
- ABLIM3 p.Glu255Lys Uncertain significance Single submitter
- ABLIM3 p.Glu268Ala Uncertain significance Single submitter
- ABLIM3 p.Glu268Lys Uncertain significance Single submitter
- ABLIM3 p.Glu348Lys Uncertain significance Single submitter
- ABLIM3 p.Glu362Lys Uncertain significance Single submitter
- ABLIM3 p.Glu508Ala Uncertain significance Single submitter
- ABLIM3 p.Glu675Gln Uncertain significance Single submitter
- ABLIM3 p.Gly125Ser Uncertain significance Single submitter
- ABLIM3 p.Gly153Arg Uncertain significance Single submitter
- ABLIM3 p.Gly161Cys Uncertain significance Single submitter
- ABLIM3 p.Gly161Ser Uncertain significance Single submitter
- ABLIM3 p.Gly194Asp Uncertain significance Single submitter
- ABLIM3 p.Gly91Ser Uncertain significance Single submitter
- ABLIM3 p.His228Tyr Uncertain significance Single submitter
- ABLIM3 p.His332Leu Uncertain significance Single submitter
- ABLIM3 p.His38Gln Uncertain significance Single submitter
- ABLIM3 p.Ile117Thr Uncertain significance Single submitter
- ABLIM3 p.Ile117Val Uncertain significance Single submitter
- ABLIM3 p.Ile474Met Uncertain significance Single submitter
- ABLIM3 p.Ile474Val Uncertain significance Single submitter
- ABLIM3 p.Ile580Phe Uncertain significance Single submitter
- ABLIM3 p.Leu350Arg Uncertain significance Single submitter
- ABLIM3 p.Leu364Val Uncertain significance Single submitter
- ABLIM3 p.Leu579Arg Uncertain significance Single submitter
- ABLIM3 p.Lys120Arg Uncertain significance Single submitter
- ABLIM3 p.Lys429Arg Uncertain significance Single submitter
- ABLIM3 p.Lys528Gln Uncertain significance Single submitter
- ABLIM3 p.Met387Ile Uncertain significance Single submitter
- ABLIM3 p.Met515Arg Uncertain significance Single submitter
- ABLIM3 p.Met562Thr Uncertain significance Single submitter
- ABLIM3 p.Pro445Leu Uncertain significance Single submitter
- ABLIM3 p.Pro578Leu Uncertain significance Single submitter
- ABLIM3 p.Pro578Ser Uncertain significance Single submitter
- ABLIM3 p.Pro598Ser Uncertain significance Single submitter
- ABLIM3 p.Pro6Arg Uncertain significance Single submitter
- ABLIM3 p.Ser140Asn Uncertain significance Single submitter
- ABLIM3 p.Ser349Trp Uncertain significance Single submitter
- ABLIM3 p.Ser536Asn Uncertain significance Single submitter
- ABLIM3 p.Ser576Gly Uncertain significance Single submitter
- ABLIM3 p.Thr352Ile Uncertain significance Single submitter
- ABLIM3 p.Thr423Ala Uncertain significance Single submitter
- ABLIM3 p.Thr455Ile Uncertain significance Single submitter
- ABLIM3 p.Thr543Ala Uncertain significance Single submitter
- ABLIM3 p.Thr549Ala Uncertain significance Single submitter
- ABLIM3 p.Thr597Ala Uncertain significance Single submitter
- ABLIM3 p.Tyr490His Uncertain significance Single submitter
- ABLIM3 p.Tyr78His Uncertain significance Single submitter
- ABLIM3 p.Val20Ile Uncertain significance Single submitter
- ABLIM3 p.Val321Ile Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- ABLIM3 p.Arg513Cys Uncertain significance Multiple submitters
- ABLIM3 p.Ala297Val Uncertain significance Single submitter
- ABLIM3 p.Arg15Trp Uncertain significance Single submitter
- ABLIM3 p.Arg215Gln Uncertain significance Single submitter
- ABLIM3 p.Arg266Gln Uncertain significance Single submitter
- ABLIM3 p.Arg323Cys Uncertain significance Single submitter
- ABLIM3 p.Arg323His Uncertain significance Single submitter
- ABLIM3 p.Arg367Gln Uncertain significance Single submitter
- ABLIM3 p.Arg367Gly Uncertain significance Single submitter
- ABLIM3 p.Arg367Leu Uncertain significance Single submitter
- ABLIM3 p.Arg370Gln Uncertain significance Single submitter
- ABLIM3 p.Arg384Gln Uncertain significance Single submitter
- ABLIM3 p.Arg393Cys Uncertain significance Single submitter
- ABLIM3 p.Arg407Gln Uncertain significance Single submitter
- ABLIM3 p.Arg449Trp Uncertain significance Single submitter
- ABLIM3 p.Arg498Gln Uncertain significance Single submitter
- ABLIM3 p.Arg534Trp Uncertain significance Single submitter
- ABLIM3 p.Arg546Gln Uncertain significance Single submitter
- ABLIM3 p.Arg552Trp Uncertain significance Single submitter
- ABLIM3 p.Arg667Gln Uncertain significance Single submitter
- ABLIM3 p.Arg681Gln Uncertain significance Single submitter
- ABLIM3 p.Arg81Cys Uncertain significance Single submitter
- ABLIM3 p.Arg81His Uncertain significance Single submitter
- ABLIM3 p.Arg86Trp Uncertain significance Single submitter
- ABLIM3 p.Arg99His Uncertain significance Single submitter
- ABLIM3 p.Asp325Asn Uncertain significance Single submitter
- ABLIM3 p.Asp87Ala Uncertain significance Single submitter
- ABLIM3 p.Cys296Tyr Uncertain significance Single submitter
- ABLIM3 p.Glu320Lys Uncertain significance Single submitter
- ABLIM3 p.Glu404Lys Uncertain significance Single submitter
- ABLIM3 p.Glu652Lys Uncertain significance Single submitter
- ABLIM3 p.His430Asn Uncertain significance Single submitter
- ABLIM3 p.Ile143Phe Uncertain significance Single submitter
- ABLIM3 p.Ile303Thr Uncertain significance Single submitter
- ABLIM3 p.Ile465Thr Uncertain significance Single submitter
- ABLIM3 p.Lys155Glu Uncertain significance Single submitter
- ABLIM3 p.Pro284Arg Uncertain significance Single submitter
- ABLIM3 p.Pro374Leu Uncertain significance Single submitter
- ABLIM3 p.Pro380Leu Uncertain significance Single submitter
- ABLIM3 p.Pro445Ser Uncertain significance Single submitter
- ABLIM3 p.Ser136Tyr Uncertain significance Single submitter
- ABLIM3 p.Ser140Arg Uncertain significance Single submitter
- ABLIM3 p.Ser280Pro Uncertain significance Single submitter
- ABLIM3 p.Ser419Tyr Uncertain significance Single submitter
- ABLIM3 p.Ser570Leu Uncertain significance Single submitter
- ABLIM3 p.Ser583Pro Uncertain significance Single submitter
- ABLIM3 p.Ser84Asn Uncertain significance Single submitter
- ABLIM3 p.Thr457Asn Uncertain significance Single submitter
- ABLIM3 p.Thr489Ile Uncertain significance Single submitter
- ABLIM3 p.Tyr398Cys Uncertain significance Single submitter
- ABLIM3 p.Tyr399Cys Uncertain significance Single submitter
- ABLIM3 p.Val107Met Uncertain significance Single submitter
All ABLIM3 variants
Uncertain significance 121
- p.Arg513Cys Multiple submitters ⚠
- p.Ala166Gly Single submitter ⚠
- p.Ala297Val Single submitter ⚠
- p.Ala371Asp Single submitter ⚠
- p.Ala600Pro Single submitter ⚠
- p.Arg15Trp Single submitter ⚠
- p.Arg215Gln Single submitter ⚠
- p.Arg238Cys Single submitter ⚠
- p.Arg25Cys Single submitter ⚠
- p.Arg266Gln Single submitter ⚠
- p.Arg266Trp Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg367Gly Single submitter ⚠
- p.Arg367Leu Single submitter ⚠
- p.Arg36His Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg384Gln Single submitter ⚠
- p.Arg393Cys Single submitter ⚠
- p.Arg407Gln Single submitter ⚠
- p.Arg449Trp Single submitter ⚠
- p.Arg498Gln Single submitter ⚠
- p.Arg513His Single submitter ⚠
- p.Arg534Trp Single submitter ⚠
- p.Arg546Gln Single submitter ⚠
- p.Arg552Trp Single submitter ⚠
- p.Arg596Gly Single submitter ⚠
- p.Arg667Gln Single submitter ⚠
- p.Arg681Gln Single submitter ⚠
- p.Arg81Cys Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Arg86Gln Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Asp338Asn Single submitter ⚠
- p.Asp509Glu Single submitter ⚠
- p.Asp512Glu Single submitter ⚠
- p.Asp606Asn Single submitter ⚠
- p.Asp87Ala Single submitter ⚠
- p.Cys261Tyr Single submitter ⚠
- p.Cys296Tyr Single submitter ⚠
- p.Cys54Tyr Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu268Ala Single submitter ⚠
- p.Glu268Lys Single submitter ⚠
- p.Glu320Lys Single submitter ⚠
- p.Glu348Lys Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu404Lys Single submitter ⚠
- p.Glu508Ala Single submitter ⚠
- p.Glu652Lys Single submitter ⚠
- p.Glu675Gln Single submitter ⚠
- p.Gly125Ser Single submitter ⚠
- p.Gly153Arg Single submitter ⚠
- p.Gly161Cys Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly194Asp Single submitter ⚠
- p.Gly91Ser Single submitter ⚠
- p.His228Tyr Single submitter ⚠
- p.His332Leu Single submitter ⚠
- p.His38Gln Single submitter ⚠
- p.His430Asn Single submitter ⚠
- p.Ile117Thr Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile143Phe Single submitter ⚠
- p.Ile303Thr Single submitter ⚠
- p.Ile465Thr Single submitter ⚠
- p.Ile474Met Single submitter ⚠
- p.Ile474Val Single submitter ⚠
- p.Ile580Phe Single submitter ⚠
- p.Leu350Arg Single submitter ⚠
- p.Leu364Val Single submitter ⚠
- p.Leu579Arg Single submitter ⚠
- p.Lys120Arg Single submitter ⚠
- p.Lys155Glu Single submitter ⚠
- p.Lys429Arg Single submitter ⚠
- p.Lys528Gln Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Met515Arg Single submitter ⚠
- p.Met562Thr Single submitter ⚠
- p.Pro284Arg Single submitter ⚠
- p.Pro374Leu Single submitter ⚠
- p.Pro380Leu Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro445Ser Single submitter ⚠
- p.Pro578Leu Single submitter ⚠
- p.Pro578Ser Single submitter ⚠
- p.Pro598Ser Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Ser136Tyr Single submitter ⚠
- p.Ser140Arg Single submitter ⚠
- p.Ser140Asn Single submitter ⚠
- p.Ser280Pro Single submitter ⚠
- p.Ser349Trp Single submitter ⚠
- p.Ser419Tyr Single submitter ⚠
- p.Ser536Asn Single submitter ⚠
- p.Ser570Leu Single submitter ⚠
- p.Ser576Gly Single submitter ⚠
- p.Ser583Pro Single submitter ⚠
- p.Ser84Asn Single submitter ⚠
- p.Thr352Ile Single submitter ⚠
- p.Thr423Ala Single submitter ⚠
- p.Thr455Ile Single submitter ⚠
- p.Thr457Asn Single submitter ⚠
- p.Thr489Ile Single submitter ⚠
- p.Thr543Ala Single submitter ⚠
- p.Thr549Ala Single submitter ⚠
- p.Thr597Ala Single submitter ⚠
- p.Tyr398Cys Single submitter ⚠
- p.Tyr399Cys Single submitter ⚠
- p.Tyr490His Single submitter ⚠
- p.Tyr78His Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val20Ile Single submitter ⚠
- p.Val321Ile Single submitter ⚠
- p.Leu555= No assertion criteria
- p.Lys528= No assertion criteria