ACAD10 — 155 ClinVar variants
All ClinVar germline ACAD10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 148 flagged for review →
11 Likely benign · 144 Uncertain significance
Full ACAD10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 148
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACAD10 p.Ala1014Val Uncertain significance Single submitter
- ACAD10 p.Ala1048Val Uncertain significance Single submitter
- ACAD10 p.Ala222Ser Uncertain significance Single submitter
- ACAD10 p.Ala593Thr Uncertain significance Single submitter
- ACAD10 p.Ala597Thr Uncertain significance Single submitter
- ACAD10 p.Ala978Val Uncertain significance Single submitter
- ACAD10 p.Arg1010Pro Uncertain significance Single submitter
- ACAD10 p.Arg1058His Uncertain significance Single submitter
- ACAD10 p.Arg603Gln Uncertain significance Single submitter
- ACAD10 p.Arg669Pro Uncertain significance Single submitter
- ACAD10 p.Asn297His Uncertain significance Single submitter
- ACAD10 p.Asn345Asp Uncertain significance Single submitter
- ACAD10 p.Asn715Lys Uncertain significance Single submitter
- ACAD10 p.Asn715Ser Uncertain significance Single submitter
- ACAD10 p.Asn85Asp Uncertain significance Single submitter
- ACAD10 p.Asp212Asn Uncertain significance Single submitter
- ACAD10 p.Asp982Glu Uncertain significance Single submitter
- ACAD10 p.Cys500Arg Uncertain significance Single submitter
- ACAD10 p.Glu665Asp Uncertain significance Single submitter
- ACAD10 p.Gly252Cys Uncertain significance Single submitter
- ACAD10 p.Gly284Asp Uncertain significance Single submitter
- ACAD10 p.Gly294Arg Uncertain significance Single submitter
- ACAD10 p.Gly58Ala Uncertain significance Single submitter
- ACAD10 p.Gly904Ala Uncertain significance Single submitter
- ACAD10 p.Gly906Val Uncertain significance Single submitter
- ACAD10 p.Gly927Arg Uncertain significance Single submitter
- ACAD10 p.Gly985Glu Uncertain significance Single submitter
- ACAD10 p.His28Tyr Uncertain significance Single submitter
- ACAD10 p.His450Arg Uncertain significance Single submitter
- ACAD10 p.His847Arg Uncertain significance Single submitter
- ACAD10 p.Ile209Val Uncertain significance Single submitter
- ACAD10 p.Ile387Val Uncertain significance Single submitter
- ACAD10 p.Ile398Val Uncertain significance Single submitter
- ACAD10 p.Ile654Val Uncertain significance Single submitter
- ACAD10 p.Leu21Arg Uncertain significance Single submitter
- ACAD10 p.Leu270Ser Uncertain significance Single submitter
- ACAD10 p.Leu489Ser Uncertain significance Single submitter
- ACAD10 p.Leu732Pro Uncertain significance Single submitter
- ACAD10 p.Lys173Glu Uncertain significance Single submitter
- ACAD10 p.Lys941Arg Uncertain significance Single submitter
- ACAD10 p.Lys941Thr Uncertain significance Single submitter
- ACAD10 p.Met744Ile Uncertain significance Single submitter
- ACAD10 p.Phe167Tyr Uncertain significance Single submitter
- ACAD10 p.Phe464Ile Uncertain significance Single submitter
- ACAD10 p.Phe532Cys Uncertain significance Single submitter
- ACAD10 p.Phe556Ser Uncertain significance Single submitter
- ACAD10 p.Pro342Arg Uncertain significance Single submitter
- ACAD10 p.Pro492Thr Uncertain significance Single submitter
- ACAD10 p.Pro526Arg Uncertain significance Single submitter
- ACAD10 p.Pro55Ala Uncertain significance Single submitter
- ACAD10 p.Ser554Cys Uncertain significance Single submitter
- ACAD10 p.Ser660Pro Uncertain significance Single submitter
- ACAD10 p.Ser747Phe Uncertain significance Single submitter
- ACAD10 p.Ser963Leu Uncertain significance Single submitter
- ACAD10 p.Thr1049Met Uncertain significance Single submitter
- ACAD10 p.Val478Gly Uncertain significance Single submitter
- ACAD10 p.Val478Met Uncertain significance Single submitter
- ACAD10 p.Val965Leu Uncertain significance Single submitter
- ACAD10 p.Val965Met Uncertain significance Single submitter
Predictors split 89
The independent predictors disagree with each other — read with care.
- ACAD10 p.Ala1000Ser Uncertain significance Single submitter
- ACAD10 p.Ala44Val Uncertain significance Single submitter
- ACAD10 p.Ala910Val Uncertain significance Single submitter
- ACAD10 p.Ala961Val Uncertain significance Single submitter
- ACAD10 p.Arg1006Gln Uncertain significance Single submitter
- ACAD10 p.Arg1010His Uncertain significance Single submitter
- ACAD10 p.Arg1034Gln Uncertain significance Single submitter
- ACAD10 p.Arg1047Trp Uncertain significance Single submitter
- ACAD10 p.Arg1058Cys Uncertain significance Single submitter
- ACAD10 p.Arg11His Uncertain significance Single submitter
- ACAD10 p.Arg146Trp Uncertain significance Single submitter
- ACAD10 p.Arg172Gln Uncertain significance Single submitter
- ACAD10 p.Arg307Cys Uncertain significance Single submitter
- ACAD10 p.Arg385Gln Uncertain significance Single submitter
- ACAD10 p.Arg420Cys Uncertain significance Single submitter
- ACAD10 p.Arg453Cys Uncertain significance Single submitter
- ACAD10 p.Arg453His Likely benign Single submitter
- ACAD10 p.Arg669Trp Uncertain significance Single submitter
- ACAD10 p.Arg778Cys Uncertain significance Single submitter
- ACAD10 p.Arg789Cys Uncertain significance Single submitter
- ACAD10 p.Arg852Trp Uncertain significance Single submitter
- ACAD10 p.Arg870Gln Uncertain significance Single submitter
- ACAD10 p.Arg870Trp Uncertain significance Single submitter
- ACAD10 p.Arg888Gln Uncertain significance Single submitter
- ACAD10 p.Arg893Cys Uncertain significance Single submitter
- ACAD10 p.Arg893His Likely benign Single submitter
- ACAD10 p.Arg943Cys Uncertain significance Single submitter
- ACAD10 p.Arg964His Uncertain significance Single submitter
- ACAD10 p.Arg971Gln Uncertain significance Single submitter
- ACAD10 p.Asn898Ser Uncertain significance Single submitter
- ACAD10 p.Asp1023Asn Uncertain significance Single submitter
- ACAD10 p.Asp467Asn Uncertain significance Single submitter
- ACAD10 p.Gln775Leu Uncertain significance Single submitter
- ACAD10 p.Glu1044Lys Uncertain significance Single submitter
- ACAD10 p.Glu441Gly Uncertain significance Single submitter
- ACAD10 p.Glu587Lys Uncertain significance Single submitter
- ACAD10 p.Glu725Gln Uncertain significance Single submitter
- ACAD10 p.Glu725Lys Uncertain significance Single submitter
- ACAD10 p.Gly202Ser Uncertain significance Single submitter
- ACAD10 p.Gly215Glu Uncertain significance Single submitter
- ACAD10 p.Gly246Asp Uncertain significance Single submitter
- ACAD10 p.Gly83Cys Uncertain significance Single submitter
- ACAD10 p.Ile356Thr Uncertain significance Single submitter
- ACAD10 p.Ile54Ser Uncertain significance Single submitter
- ACAD10 p.Ile75Thr Uncertain significance Single submitter
- ACAD10 p.Leu309Ile Uncertain significance Single submitter
- ACAD10 p.Leu469Val Uncertain significance Single submitter
- ACAD10 p.Leu486Val Uncertain significance Single submitter
- ACAD10 p.Lys165Asn Uncertain significance Single submitter
- ACAD10 p.Lys707Asn Uncertain significance Single submitter
- ACAD10 p.Lys896Glu Uncertain significance Single submitter
- ACAD10 p.Lys987Thr Uncertain significance Single submitter
- ACAD10 p.Met440Thr Uncertain significance Single submitter
- ACAD10 p.Met49Arg Uncertain significance Single submitter
- ACAD10 p.Met534Val Uncertain significance Single submitter
- ACAD10 p.Met764Thr Uncertain significance Single submitter
- ACAD10 p.Met899Ile Uncertain significance Single submitter
- ACAD10 p.Met936Val Uncertain significance Single submitter
- ACAD10 p.Phe1029Leu Uncertain significance Single submitter
- ACAD10 p.Phe159Val Uncertain significance Single submitter
- ACAD10 p.Phe91Leu Uncertain significance Single submitter
- ACAD10 p.Pro1025Ser Uncertain significance Single submitter
- ACAD10 p.Pro169Ser Uncertain significance Single submitter
- ACAD10 p.Pro316Ser Uncertain significance Single submitter
- ACAD10 p.Pro374Leu Uncertain significance Single submitter
- ACAD10 p.Pro452Ala Uncertain significance Single submitter
- ACAD10 p.Pro476Thr Likely benign Single submitter
- ACAD10 p.Pro895Ser Uncertain significance Single submitter
- ACAD10 p.Ser400Asn Uncertain significance Single submitter
- ACAD10 p.Ser507Cys Uncertain significance Single submitter
- ACAD10 p.Ser637Gly Uncertain significance Single submitter
- ACAD10 p.Ser687Gly Uncertain significance Single submitter
- ACAD10 p.Thr236Ile Uncertain significance Single submitter
- ACAD10 p.Thr24Asn Uncertain significance Single submitter
- ACAD10 p.Thr457Asn Uncertain significance Single submitter
- ACAD10 p.Thr521Ile Uncertain significance Single submitter
- ACAD10 p.Thr746Lys Uncertain significance Single submitter
- ACAD10 p.Thr761Met Uncertain significance Single submitter
- ACAD10 p.Thr873Lys Uncertain significance Single submitter
- ACAD10 p.Thr873Met Uncertain significance Single submitter
- ACAD10 p.Thr955Lys Uncertain significance Single submitter
- ACAD10 p.Thr97Ile Uncertain significance Single submitter
- ACAD10 p.Tyr417Cys Uncertain significance Single submitter
- ACAD10 p.Val117Met Uncertain significance Single submitter
- ACAD10 p.Val470Met Uncertain significance Single submitter
- ACAD10 p.Val481Ile Uncertain significance Single submitter
- ACAD10 p.Val496Ala Uncertain significance Single submitter
- ACAD10 p.Val768Met Uncertain significance Single submitter
-
ACAD10 p.Arg789His
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All ACAD10 variants
Likely benign 11
- p.Arg11Cys Single submitter
- p.Arg130Gln Single submitter
- p.Arg257Gln Single submitter
- p.Arg453His Single submitter ⚠
- p.Arg893His Single submitter ⚠
- p.Asp463Asn Single submitter
- p.Gln627Leu Single submitter
- p.Gly100Asp Single submitter
- p.Ile178Val Single submitter
- p.Pro476Thr Single submitter ⚠
- p.Arg789His No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 144
- p.Ala1000Ser Single submitter ⚠
- p.Ala1014Val Single submitter ⚠
- p.Ala1048Val Single submitter ⚠
- p.Ala222Ser Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Ala593Thr Single submitter ⚠
- p.Ala597Thr Single submitter ⚠
- p.Ala910Val Single submitter ⚠
- p.Ala961Val Single submitter ⚠
- p.Ala978Val Single submitter ⚠
- p.Arg1006Gln Single submitter ⚠
- p.Arg1010His Single submitter ⚠
- p.Arg1010Pro Single submitter ⚠
- p.Arg1034Gln Single submitter ⚠
- p.Arg1047Trp Single submitter ⚠
- p.Arg1058Cys Single submitter ⚠
- p.Arg1058His Single submitter ⚠
- p.Arg11His Single submitter ⚠
- p.Arg146Trp Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg307Cys Single submitter ⚠
- p.Arg385Gln Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg453Cys Single submitter ⚠
- p.Arg603Gln Single submitter ⚠
- p.Arg669Pro Single submitter ⚠
- p.Arg669Trp Single submitter ⚠
- p.Arg778Cys Single submitter ⚠
- p.Arg789Cys Single submitter ⚠
- p.Arg852Trp Single submitter ⚠
- p.Arg870Gln Single submitter ⚠
- p.Arg870Trp Single submitter ⚠
- p.Arg888Gln Single submitter ⚠
- p.Arg893Cys Single submitter ⚠
- p.Arg943Cys Single submitter ⚠
- p.Arg964His Single submitter ⚠
- p.Arg971Gln Single submitter ⚠
- p.Asn297His Single submitter ⚠
- p.Asn345Asp Single submitter ⚠
- p.Asn715Lys Single submitter ⚠
- p.Asn715Ser Single submitter ⚠
- p.Asn85Asp Single submitter ⚠
- p.Asn898Ser Single submitter ⚠
- p.Asp1023Asn Single submitter ⚠
- p.Asp212Asn Single submitter ⚠
- p.Asp467Asn Single submitter ⚠
- p.Asp982Glu Single submitter ⚠
- p.Cys500Arg Single submitter ⚠
- p.Gln775Leu Single submitter ⚠
- p.Glu1044Lys Single submitter ⚠
- p.Glu441Gly Single submitter ⚠
- p.Glu587Lys Single submitter ⚠
- p.Glu665Asp Single submitter ⚠
- p.Glu725Gln Single submitter ⚠
- p.Glu725Lys Single submitter ⚠
- p.Gly202Ser Single submitter ⚠
- p.Gly215Glu Single submitter ⚠
- p.Gly246Asp Single submitter ⚠
- p.Gly252Cys Single submitter ⚠
- p.Gly284Asp Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly58Ala Single submitter ⚠
- p.Gly83Cys Single submitter ⚠
- p.Gly904Ala Single submitter ⚠
- p.Gly906Val Single submitter ⚠
- p.Gly927Arg Single submitter ⚠
- p.Gly985Glu Single submitter ⚠
- p.His28Tyr Single submitter ⚠
- p.His450Arg Single submitter ⚠
- p.His847Arg Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Ile387Val Single submitter ⚠
- p.Ile398Val Single submitter ⚠
- p.Ile54Ser Single submitter ⚠
- p.Ile654Val Single submitter ⚠
- p.Ile75Thr Single submitter ⚠
- p.Leu21Arg Single submitter ⚠
- p.Leu270Ser Single submitter ⚠
- p.Leu309Ile Single submitter ⚠
- p.Leu469Val Single submitter ⚠
- p.Leu486Val Single submitter ⚠
- p.Leu489Ser Single submitter ⚠
- p.Leu732Pro Single submitter ⚠
- p.Lys165Asn Single submitter ⚠
- p.Lys173Glu Single submitter ⚠
- p.Lys707Asn Single submitter ⚠
- p.Lys896Glu Single submitter ⚠
- p.Lys941Arg Single submitter ⚠
- p.Lys941Thr Single submitter ⚠
- p.Lys987Thr Single submitter ⚠
- p.Met440Thr Single submitter ⚠
- p.Met49Arg Single submitter ⚠
- p.Met534Val Single submitter ⚠
- p.Met744Ile Single submitter ⚠
- p.Met764Thr Single submitter ⚠
- p.Met899Ile Single submitter ⚠
- p.Met936Val Single submitter ⚠
- p.Phe1029Leu Single submitter ⚠
- p.Phe159Val Single submitter ⚠
- p.Phe167Tyr Single submitter ⚠
- p.Phe464Ile Single submitter ⚠
- p.Phe532Cys Single submitter ⚠
- p.Phe556Ser Single submitter ⚠
- p.Phe91Leu Single submitter ⚠
- p.Pro1025Ser Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Pro316Ser Single submitter ⚠
- p.Pro342Arg Single submitter ⚠
- p.Pro374Leu Single submitter ⚠
- p.Pro452Ala Single submitter ⚠
- p.Pro492Thr Single submitter ⚠
- p.Pro526Arg Single submitter ⚠
- p.Pro55Ala Single submitter ⚠
- p.Pro895Ser Single submitter ⚠
- p.Ser400Asn Single submitter ⚠
- p.Ser507Cys Single submitter ⚠
- p.Ser554Cys Single submitter ⚠
- p.Ser637Gly Single submitter ⚠
- p.Ser660Pro Single submitter ⚠
- p.Ser687Gly Single submitter ⚠
- p.Ser747Phe Single submitter ⚠
- p.Ser963Leu Single submitter ⚠
- p.Thr1049Met Single submitter ⚠
- p.Thr236Ile Single submitter ⚠
- p.Thr24Asn Single submitter ⚠
- p.Thr457Asn Single submitter ⚠
- p.Thr521Ile Single submitter ⚠
- p.Thr746Lys Single submitter ⚠
- p.Thr761Met Single submitter ⚠
- p.Thr873Lys Single submitter ⚠
- p.Thr873Met Single submitter ⚠
- p.Thr955Lys Single submitter ⚠
- p.Thr97Ile Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Val117Met Single submitter ⚠
- p.Val470Met Single submitter ⚠
- p.Val478Gly Single submitter ⚠
- p.Val478Met Single submitter ⚠
- p.Val481Ile Single submitter ⚠
- p.Val496Ala Single submitter ⚠
- p.Val768Met Single submitter ⚠
- p.Val965Leu Single submitter ⚠
- p.Val965Met Single submitter ⚠