ACAD11 — 107 ClinVar variants
All ClinVar germline ACAD11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 96 flagged for review →
1 Benign · 9 Likely benign · 97 Uncertain significance
Full ACAD11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 96
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACAD11 p.Ala191Thr Uncertain significance Single submitter
- ACAD11 p.Ala550Pro Uncertain significance Single submitter
- ACAD11 p.Ala680Gly Uncertain significance Single submitter
- ACAD11 p.Ala725Pro Uncertain significance Single submitter
- ACAD11 p.Arg678Leu Uncertain significance Single submitter
- ACAD11 p.Arg716Gln Uncertain significance Single submitter
- ACAD11 p.Asn279Asp Uncertain significance Single submitter
- ACAD11 p.Asn55Lys Uncertain significance Single submitter
- ACAD11 p.Asp10Tyr Uncertain significance Single submitter
- ACAD11 p.Asp211Asn Uncertain significance Single submitter
- ACAD11 p.Asp254Gly Uncertain significance Single submitter
- ACAD11 p.Asp413His Uncertain significance Single submitter
- ACAD11 p.Asp757His Uncertain significance Single submitter
- ACAD11 p.Asp771Asn Uncertain significance Single submitter
- ACAD11 p.Cys636Arg Uncertain significance Single submitter
- ACAD11 p.Gln365His Uncertain significance Single submitter
- ACAD11 p.Glu278Ala Uncertain significance Single submitter
- ACAD11 p.Glu431Gln Uncertain significance Single submitter
- ACAD11 p.Glu758Gly Uncertain significance Single submitter
- ACAD11 p.Gly474Glu Uncertain significance Single submitter
- ACAD11 p.His157Tyr Uncertain significance Single submitter
- ACAD11 p.Ile282Leu Uncertain significance Single submitter
- ACAD11 p.Ile384Ser Uncertain significance Single submitter
- ACAD11 p.Ile394Val Uncertain significance Single submitter
- ACAD11 p.Ile97Thr Uncertain significance Single submitter
- ACAD11 p.Lys488Asn Uncertain significance Single submitter
- ACAD11 p.Lys536Asn Uncertain significance Single submitter
- ACAD11 p.Lys546Gln Uncertain significance Single submitter
- ACAD11 p.Lys683Asn Uncertain significance Single submitter
- ACAD11 p.Phe404Leu Uncertain significance Single submitter
- ACAD11 p.Pro265Leu Uncertain significance Single submitter
- ACAD11 p.Pro364Ser Uncertain significance Single submitter
- ACAD11 p.Ser694Asn Uncertain significance Single submitter
- ACAD11 p.Thr456Arg Uncertain significance Single submitter
- ACAD11 p.Thr655Ile Uncertain significance Single submitter
- ACAD11 p.Tyr405Cys Uncertain significance Single submitter
- ACAD11 p.Val447Leu Uncertain significance Single submitter
- ACAD11 p.Val447Met Uncertain significance Single submitter
Predictors split 58
The independent predictors disagree with each other — read with care.
- ACAD11 p.Ala516Val Uncertain significance Single submitter
- ACAD11 p.Ala646Thr Uncertain significance Single submitter
- ACAD11 p.Ala741Val Uncertain significance Single submitter
- ACAD11 p.Ala765Thr Uncertain significance Single submitter
- ACAD11 p.Ala93Gly Uncertain significance Single submitter
- ACAD11 p.Arg130Cys Uncertain significance Single submitter
- ACAD11 p.Arg236Gln Uncertain significance Single submitter
- ACAD11 p.Arg525Gln Uncertain significance Single submitter
- ACAD11 p.Arg555Gly Uncertain significance Single submitter
- ACAD11 p.Arg607Gln Uncertain significance Single submitter
- ACAD11 p.Arg627Cys Uncertain significance Single submitter
- ACAD11 p.Arg678Cys Uncertain significance Single submitter
- ACAD11 p.Arg685Cys Uncertain significance Single submitter
- ACAD11 p.Arg751His Uncertain significance Single submitter
- ACAD11 p.Asn55Ser Uncertain significance Single submitter
- ACAD11 p.Gln17Pro Uncertain significance Single submitter
- ACAD11 p.Gln380Leu Uncertain significance Single submitter
- ACAD11 p.Gln48Arg Uncertain significance Single submitter
- ACAD11 p.Glu141Gly Uncertain significance Single submitter
- ACAD11 p.Glu768Gln Uncertain significance Single submitter
- ACAD11 p.Gly443Arg Uncertain significance Single submitter
- ACAD11 p.Gly534Ser Uncertain significance Single submitter
- ACAD11 p.His18Leu Uncertain significance Single submitter
- ACAD11 p.His564Tyr Uncertain significance Single submitter
- ACAD11 p.Ile248Thr Uncertain significance Single submitter
- ACAD11 p.Ile549Thr Uncertain significance Single submitter
- ACAD11 p.Ile679Val Uncertain significance Single submitter
- ACAD11 p.Ile780Thr Uncertain significance Single submitter
- ACAD11 p.Leu309Phe Uncertain significance Single submitter
- ACAD11 p.Leu354His Uncertain significance Single submitter
- ACAD11 p.Leu481Val Uncertain significance Single submitter
- ACAD11 p.Leu689Val Uncertain significance Single submitter
- ACAD11 p.Lys399Arg Uncertain significance Single submitter
- ACAD11 p.Lys414Glu Uncertain significance Single submitter
- ACAD11 p.Met198Ile Uncertain significance Single submitter
- ACAD11 p.Met476Val Uncertain significance Single submitter
- ACAD11 p.Met650Thr Uncertain significance Single submitter
- ACAD11 p.Phe340Cys Uncertain significance Single submitter
- ACAD11 p.Pro16Ser Uncertain significance Single submitter
- ACAD11 p.Pro346Ser Uncertain significance Single submitter
- ACAD11 p.Pro439Ser Uncertain significance Single submitter
- ACAD11 p.Pro463Ala Uncertain significance Single submitter
- ACAD11 p.Ser163Pro Uncertain significance Single submitter
- ACAD11 p.Ser202Leu Uncertain significance Single submitter
- ACAD11 p.Ser202Trp Uncertain significance Single submitter
- ACAD11 p.Ser24Cys Uncertain significance Single submitter
- ACAD11 p.Ser284Leu Uncertain significance Single submitter
- ACAD11 p.Ser694Gly Uncertain significance Single submitter
- ACAD11 p.Thr111Asn Uncertain significance Single submitter
- ACAD11 p.Thr556Ala Uncertain significance Single submitter
- ACAD11 p.Thr611Arg Uncertain significance Single submitter
- ACAD11 p.Thr747Ile Uncertain significance Single submitter
- ACAD11 p.Thr777Ile Uncertain significance Single submitter
- ACAD11 p.Trp415Leu Uncertain significance Single submitter
- ACAD11 p.Tyr59Cys Uncertain significance Single submitter
- ACAD11 p.Val447Gly Uncertain significance Single submitter
- ACAD11 p.Val669Asp Uncertain significance Single submitter
- ACAD11 p.Val718Leu Uncertain significance Single submitter
All ACAD11 variants
Benign 1
- p.His157= Single submitter
Likely benign 9
- p.Ala643= Single submitter
- p.Arg563= Single submitter
- p.Arg770Gln Single submitter
- p.Asp10Asn Single submitter
- p.Gln155Arg Single submitter
- p.Gly274Ser Single submitter
- p.Leu25= Single submitter
- p.Thr368Ser Single submitter
- p.Val120Ile Single submitter
Uncertain significance 97
- p.Ala191Thr Single submitter ⚠
- p.Ala516Val Single submitter ⚠
- p.Ala550Pro Single submitter ⚠
- p.Ala646Thr Single submitter ⚠
- p.Ala680Gly Single submitter ⚠
- p.Ala725Pro Single submitter ⚠
- p.Ala741Val Single submitter ⚠
- p.Ala765Thr Single submitter ⚠
- p.Ala93Gly Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg525Gln Single submitter ⚠
- p.Arg555Gly Single submitter ⚠
- p.Arg607Gln Single submitter ⚠
- p.Arg627Cys Single submitter ⚠
- p.Arg678Cys Single submitter ⚠
- p.Arg678Leu Single submitter ⚠
- p.Arg685Cys Single submitter ⚠
- p.Arg716Gln Single submitter ⚠
- p.Arg751His Single submitter ⚠
- p.Asn279Asp Single submitter ⚠
- p.Asn55Lys Single submitter ⚠
- p.Asn55Ser Single submitter ⚠
- p.Asp10Tyr Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Asp254Gly Single submitter ⚠
- p.Asp413His Single submitter ⚠
- p.Asp757His Single submitter ⚠
- p.Asp771Asn Single submitter ⚠
- p.Cys636Arg Single submitter ⚠
- p.Gln17Pro Single submitter ⚠
- p.Gln365His Single submitter ⚠
- p.Gln380Leu Single submitter ⚠
- p.Gln48Arg Single submitter ⚠
- p.Glu141Gly Single submitter ⚠
- p.Glu278Ala Single submitter ⚠
- p.Glu431Gln Single submitter ⚠
- p.Glu758Gly Single submitter ⚠
- p.Glu768Gln Single submitter ⚠
- p.Gly443Arg Single submitter ⚠
- p.Gly474Glu Single submitter ⚠
- p.Gly534Ser Single submitter ⚠
- p.His157Tyr Single submitter ⚠
- p.His18Leu Single submitter ⚠
- p.His564Tyr Single submitter ⚠
- p.Ile248Thr Single submitter ⚠
- p.Ile282Leu Single submitter ⚠
- p.Ile384Ser Single submitter ⚠
- p.Ile394Val Single submitter ⚠
- p.Ile549Thr Single submitter ⚠
- p.Ile679Val Single submitter ⚠
- p.Ile780Thr Single submitter ⚠
- p.Ile97Thr Single submitter ⚠
- p.Leu309Phe Single submitter ⚠
- p.Leu354His Single submitter ⚠
- p.Leu481= Single submitter
- p.Leu481Val Single submitter ⚠
- p.Leu689Val Single submitter ⚠
- p.Lys399Arg Single submitter ⚠
- p.Lys414Glu Single submitter ⚠
- p.Lys488Asn Single submitter ⚠
- p.Lys536Asn Single submitter ⚠
- p.Lys546Gln Single submitter ⚠
- p.Lys683Asn Single submitter ⚠
- p.Met198Ile Single submitter ⚠
- p.Met476Val Single submitter ⚠
- p.Met650Thr Single submitter ⚠
- p.Phe340Cys Single submitter ⚠
- p.Phe404Leu Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro265Leu Single submitter ⚠
- p.Pro346Ser Single submitter ⚠
- p.Pro364Ser Single submitter ⚠
- p.Pro439Ser Single submitter ⚠
- p.Pro463Ala Single submitter ⚠
- p.Ser163Pro Single submitter ⚠
- p.Ser202Leu Single submitter ⚠
- p.Ser202Trp Single submitter ⚠
- p.Ser24Cys Single submitter ⚠
- p.Ser284Leu Single submitter ⚠
- p.Ser694Asn Single submitter ⚠
- p.Ser694Gly Single submitter ⚠
- p.Thr111Asn Single submitter ⚠
- p.Thr456Arg Single submitter ⚠
- p.Thr556Ala Single submitter ⚠
- p.Thr611Arg Single submitter ⚠
- p.Thr655Ile Single submitter ⚠
- p.Thr747Ile Single submitter ⚠
- p.Thr777Ile Single submitter ⚠
- p.Trp415Leu Single submitter ⚠
- p.Tyr405Cys Single submitter ⚠
- p.Tyr59Cys Single submitter ⚠
- p.Val447Gly Single submitter ⚠
- p.Val447Leu Single submitter ⚠
- p.Val447Met Single submitter ⚠
- p.Val669Asp Single submitter ⚠
- p.Val718Leu Single submitter ⚠