ACCSL — 87 ClinVar variants
All ClinVar germline ACCSL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
6 Likely benign · 81 Uncertain significance
Full ACCSL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACCSL p.Ala111Val Uncertain significance Single submitter
- ACCSL p.Ala87Val Uncertain significance Single submitter
- ACCSL p.Arg102Ser Uncertain significance Single submitter
- ACCSL p.Arg133His Uncertain significance Single submitter
- ACCSL p.Arg478Cys Uncertain significance Single submitter
- ACCSL p.Arg4Gln Uncertain significance Single submitter
- ACCSL p.Asn154Ser Uncertain significance Single submitter
- ACCSL p.Asn352Ser Uncertain significance Single submitter
- ACCSL p.Asp100Asn Uncertain significance Single submitter
- ACCSL p.Cys126Tyr Uncertain significance Single submitter
- ACCSL p.Gln553His Uncertain significance Single submitter
- ACCSL p.Glu359Asp Uncertain significance Single submitter
- ACCSL p.Glu555Ala Uncertain significance Single submitter
- ACCSL p.Glu91Gln Uncertain significance Single submitter
- ACCSL p.Gly103Val Uncertain significance Single submitter
- ACCSL p.Gly322Asp Uncertain significance Single submitter
- ACCSL p.Ile356Val Uncertain significance Single submitter
- ACCSL p.Ile357Val Uncertain significance Single submitter
- ACCSL p.Ile558Met Uncertain significance Single submitter
- ACCSL p.Leu311Ile Uncertain significance Single submitter
- ACCSL p.Lys279Asn Uncertain significance Single submitter
- ACCSL p.Phe372Leu Uncertain significance Single submitter
- ACCSL p.Pro11Ser Uncertain significance Single submitter
- ACCSL p.Ser148Leu Uncertain significance Single submitter
- ACCSL p.Ser289Arg Uncertain significance Single submitter
- ACCSL p.Trp207Arg Uncertain significance Single submitter
- ACCSL p.Trp391Arg Uncertain significance Single submitter
- ACCSL p.Tyr344Cys Uncertain significance Single submitter
- ACCSL p.Tyr455Cys Uncertain significance Single submitter
Predictors split 51
The independent predictors disagree with each other — read with care.
- ACCSL p.Ala248Val Uncertain significance Single submitter
- ACCSL p.Ala460Val Uncertain significance Single submitter
- ACCSL p.Arg138Cys Uncertain significance Single submitter
- ACCSL p.Arg214Gln Uncertain significance Single submitter
- ACCSL p.Arg219Gln Uncertain significance Single submitter
- ACCSL p.Arg321Gln Uncertain significance Single submitter
- ACCSL p.Arg321Gly Uncertain significance Single submitter
- ACCSL p.Arg403Cys Uncertain significance Single submitter
- ACCSL p.Arg456Leu Uncertain significance Single submitter
- ACCSL p.Arg456Trp Uncertain significance Single submitter
- ACCSL p.Arg506Cys Uncertain significance Single submitter
- ACCSL p.Arg538Gln Uncertain significance Single submitter
- ACCSL p.Arg538Trp Uncertain significance Single submitter
- ACCSL p.Arg545Pro Uncertain significance Single submitter
- ACCSL p.Arg77Trp Uncertain significance Single submitter
- ACCSL p.Asn411Lys Uncertain significance Single submitter
- ACCSL p.Asp141His Uncertain significance Single submitter
- ACCSL p.Asp193Tyr Uncertain significance Single submitter
- ACCSL p.Asp206His Uncertain significance Single submitter
- ACCSL p.Asp255Gly Uncertain significance Single submitter
- ACCSL p.Asp367Ala Uncertain significance Single submitter
- ACCSL p.Asp493Gly Uncertain significance Single submitter
- ACCSL p.Cys495Arg Uncertain significance Single submitter
- ACCSL p.Gln210Lys Uncertain significance Single submitter
- ACCSL p.Gln300Leu Uncertain significance Single submitter
- ACCSL p.Gly169Asp Uncertain significance Single submitter
- ACCSL p.Gly174Ser Uncertain significance Single submitter
- ACCSL p.Gly429Val Uncertain significance Single submitter
- ACCSL p.Gly481Asp Uncertain significance Single submitter
- ACCSL p.Ile171Val Uncertain significance Single submitter
- ACCSL p.Leu184Pro Uncertain significance Single submitter
- ACCSL p.Leu301Phe Uncertain significance Single submitter
- ACCSL p.Leu353Ile Uncertain significance Single submitter
- ACCSL p.Leu541Ser Uncertain significance Single submitter
- ACCSL p.Lys319Asn Uncertain significance Single submitter
- ACCSL p.Lys434Asn Uncertain significance Single submitter
- ACCSL p.Lys511Asn Uncertain significance Single submitter
- ACCSL p.Phe421Leu Uncertain significance Single submitter
- ACCSL p.Phe421Tyr Uncertain significance Single submitter
- ACCSL p.Pro331Ala Uncertain significance Single submitter
- ACCSL p.Ser124Asn Uncertain significance Single submitter
- ACCSL p.Ser369Phe Uncertain significance Single submitter
- ACCSL p.Thr200Ile Uncertain significance Single submitter
- ACCSL p.Thr229Ile Uncertain significance Single submitter
- ACCSL p.Thr41Met Uncertain significance Single submitter
- ACCSL p.Thr48Met Uncertain significance Single submitter
- ACCSL p.Tyr161His Uncertain significance Single submitter
- ACCSL p.Tyr224Cys Uncertain significance Single submitter
- ACCSL p.Tyr267Ser Uncertain significance Single submitter
- ACCSL p.Tyr483His Uncertain significance Single submitter
- ACCSL p.Val236Met Uncertain significance Single submitter
All ACCSL variants
Likely benign 6
- p.Ala87Thr Single submitter
- p.Arg350= Single submitter
- p.Arg516Cys Single submitter
- p.Glu472Lys Single submitter
- p.His297Gln Single submitter
- p.Ser426Gly Single submitter
Uncertain significance 81
- p.Ala111Val Single submitter ⚠
- p.Ala248Val Single submitter ⚠
- p.Ala460Val Single submitter ⚠
- p.Ala87Val Single submitter ⚠
- p.Arg102Ser Single submitter ⚠
- p.Arg133His Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg219Gln Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg321Gly Single submitter ⚠
- p.Arg403Cys Single submitter ⚠
- p.Arg456Leu Single submitter ⚠
- p.Arg456Trp Single submitter ⚠
- p.Arg478Cys Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg506Cys Single submitter ⚠
- p.Arg538Gln Single submitter ⚠
- p.Arg538Trp Single submitter ⚠
- p.Arg545Pro Single submitter ⚠
- p.Arg77Trp Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn352Ser Single submitter ⚠
- p.Asn411Lys Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp141His Single submitter ⚠
- p.Asp193Tyr Single submitter ⚠
- p.Asp206His Single submitter ⚠
- p.Asp255Gly Single submitter ⚠
- p.Asp367Ala Single submitter ⚠
- p.Asp493Gly Single submitter ⚠
- p.Cys126Tyr Single submitter ⚠
- p.Cys495Arg Single submitter ⚠
- p.Gln210Lys Single submitter ⚠
- p.Gln300Leu Single submitter ⚠
- p.Gln553His Single submitter ⚠
- p.Glu359Asp Single submitter ⚠
- p.Glu555Ala Single submitter ⚠
- p.Glu56Ter Single submitter
- p.Glu91Gln Single submitter ⚠
- p.Gly103Val Single submitter ⚠
- p.Gly169Asp Single submitter ⚠
- p.Gly174Ser Single submitter ⚠
- p.Gly322Asp Single submitter ⚠
- p.Gly429Val Single submitter ⚠
- p.Gly481Asp Single submitter ⚠
- p.Ile171Val Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Ile357Val Single submitter ⚠
- p.Ile558Met Single submitter ⚠
- p.Leu184Pro Single submitter ⚠
- p.Leu301Phe Single submitter ⚠
- p.Leu311Ile Single submitter ⚠
- p.Leu353Ile Single submitter ⚠
- p.Leu541Ser Single submitter ⚠
- p.Lys279Asn Single submitter ⚠
- p.Lys319Asn Single submitter ⚠
- p.Lys434Asn Single submitter ⚠
- p.Lys511Asn Single submitter ⚠
- p.Phe372Leu Single submitter ⚠
- p.Phe421Leu Single submitter ⚠
- p.Phe421Tyr Single submitter ⚠
- p.Pro11Ser Single submitter ⚠
- p.Pro331Ala Single submitter ⚠
- p.Ser124Asn Single submitter ⚠
- p.Ser148Leu Single submitter ⚠
- p.Ser289Arg Single submitter ⚠
- p.Ser369Phe Single submitter ⚠
- p.Thr200Ile Single submitter ⚠
- p.Thr229Ile Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Thr48Met Single submitter ⚠
- p.Trp207Arg Single submitter ⚠
- p.Trp391Arg Single submitter ⚠
- p.Tyr161His Single submitter ⚠
- p.Tyr224Cys Single submitter ⚠
- p.Tyr267Ser Single submitter ⚠
- p.Tyr344Cys Single submitter ⚠
- p.Tyr455Cys Single submitter ⚠
- p.Tyr483His Single submitter ⚠
- p.Val236Met Single submitter ⚠