ACIN1 — 173 ClinVar variants
All ClinVar germline ACIN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 168 flagged for review →
5 Likely benign · 168 Uncertain significance
Full ACIN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 168
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 98
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACIN1 c.-18C>T Uncertain significance Single submitter
- ACIN1 c.-23C>A Uncertain significance Single submitter
- ACIN1 p.Ala502Val Uncertain significance Single submitter
- ACIN1 p.Ala557Val Uncertain significance Single submitter
- ACIN1 p.Ala735Val Uncertain significance Single submitter
- ACIN1 p.Ala824Val Uncertain significance Single submitter
- ACIN1 p.Arg1074Gln Uncertain significance Single submitter
- ACIN1 p.Arg1074Trp Uncertain significance Single submitter
- ACIN1 p.Arg1158Gln Uncertain significance Single submitter
- ACIN1 p.Arg135Lys Uncertain significance Single submitter
- ACIN1 p.Arg142Ser Uncertain significance Single submitter
- ACIN1 p.Arg14Gln Uncertain significance Single submitter
- ACIN1 p.Arg164Lys Uncertain significance Single submitter
- ACIN1 p.Arg164Thr Uncertain significance Single submitter
- ACIN1 p.Arg168Gly Uncertain significance Single submitter
- ACIN1 p.Arg207Gly Uncertain significance Single submitter
- ACIN1 p.Arg338Gln Uncertain significance Single submitter
- ACIN1 p.Arg500Lys Uncertain significance Single submitter
- ACIN1 p.Arg511Ser Uncertain significance Single submitter
- ACIN1 p.Arg580Ser Uncertain significance Single submitter
- ACIN1 p.Arg650Gly Uncertain significance Single submitter
- ACIN1 p.Arg650His Uncertain significance Single submitter
- ACIN1 p.Arg669Pro Uncertain significance Single submitter
- ACIN1 p.Arg743His Uncertain significance Single submitter
- ACIN1 p.Asn564Asp Uncertain significance Single submitter
- ACIN1 p.Asn593Ser Uncertain significance Single submitter
- ACIN1 p.Asn721Ser Uncertain significance Single submitter
- ACIN1 p.Asn740Ser Uncertain significance Single submitter
- ACIN1 p.Asp400Asn Uncertain significance Single submitter
- ACIN1 p.Asp402Gly Uncertain significance Single submitter
- ACIN1 p.Asp517Asn Uncertain significance Single submitter
- ACIN1 p.Asp742Ala Uncertain significance Single submitter
- ACIN1 p.Cys633Phe Uncertain significance Single submitter
- ACIN1 p.Cys633Ser Uncertain significance Single submitter
- ACIN1 p.Gln1145Glu Uncertain significance Single submitter
- ACIN1 p.Gln194Glu Uncertain significance Single submitter
- ACIN1 p.Glu1052Asp Uncertain significance Single submitter
- ACIN1 p.Glu1208Ala Uncertain significance Single submitter
- ACIN1 p.Glu134Lys Uncertain significance Single submitter
- ACIN1 p.Glu183Gln Uncertain significance Single submitter
- ACIN1 p.Glu24Lys Uncertain significance Single submitter
- ACIN1 p.Glu348Gln Uncertain significance Single submitter
- ACIN1 p.Glu377Lys Uncertain significance Single submitter
- ACIN1 p.Glu3Asp Uncertain significance Single submitter
- ACIN1 p.Glu431Gln Uncertain significance Single submitter
- ACIN1 p.Glu463Gln Uncertain significance Single submitter
- ACIN1 p.Glu477Gly Uncertain significance Single submitter
- ACIN1 p.Glu486Ala Uncertain significance Single submitter
- ACIN1 p.Glu668Gln Uncertain significance Single submitter
- ACIN1 p.Glu681Gln Uncertain significance Single submitter
- ACIN1 p.Gly1013Arg Uncertain significance Single submitter
- ACIN1 p.Gly619Val Uncertain significance Single submitter
- ACIN1 p.Gly851Glu Uncertain significance Single submitter
- ACIN1 p.His6Asp Uncertain significance Single submitter
- ACIN1 p.Ile1055Met Uncertain significance Single submitter
- ACIN1 p.Ile380Arg Uncertain significance Single submitter
- ACIN1 p.Ile392Leu Uncertain significance Single submitter
- ACIN1 p.Ile484Val Uncertain significance Single submitter
- ACIN1 p.Ile734Val Uncertain significance Single submitter
- ACIN1 p.Ile952Val Uncertain significance Single submitter
- ACIN1 p.Ile987Thr Uncertain significance Single submitter
- ACIN1 p.Leu124Arg Uncertain significance Single submitter
- ACIN1 p.Leu343Pro Uncertain significance Single submitter
- ACIN1 p.Leu391Ile Uncertain significance Single submitter
- ACIN1 p.Leu445Val Uncertain significance Single submitter
- ACIN1 p.Leu4Val Uncertain significance Single submitter
- ACIN1 p.Leu651Arg Uncertain significance Single submitter
- ACIN1 p.Lys570Arg Uncertain significance Single submitter
- ACIN1 p.Lys673Gln Uncertain significance Single submitter
- ACIN1 p.Met261Lys Uncertain significance Single submitter
- ACIN1 p.Met261Thr Uncertain significance Single submitter
- ACIN1 p.Met383Ile Uncertain significance Single submitter
- ACIN1 p.Pro1070Leu Uncertain significance Single submitter
- ACIN1 p.Pro197Ser Uncertain significance Single submitter
- ACIN1 p.Pro266Leu Uncertain significance Single submitter
- ACIN1 p.Pro331Leu Uncertain significance Single submitter
- ACIN1 p.Pro357Ser Uncertain significance Single submitter
- ACIN1 p.Pro369Leu Uncertain significance Single submitter
- ACIN1 p.Pro508Ser Uncertain significance Single submitter
- ACIN1 p.Pro625Leu Uncertain significance Single submitter
- ACIN1 p.Pro744Thr Uncertain significance Single submitter
- ACIN1 p.Ser111Leu Uncertain significance Single submitter
- ACIN1 p.Ser185Gly Uncertain significance Single submitter
- ACIN1 p.Ser376Gly Uncertain significance Single submitter
- ACIN1 p.Ser455Pro Uncertain significance Single submitter
- ACIN1 p.Ser606Thr Uncertain significance Single submitter
- ACIN1 p.Ser642Pro Uncertain significance Single submitter
- ACIN1 p.Ser757Leu Uncertain significance Single submitter
- ACIN1 p.Thr34Ala Uncertain significance Single submitter
- ACIN1 p.Thr611Ala Uncertain significance Single submitter
- ACIN1 p.Thr772Ile Uncertain significance Single submitter
- ACIN1 p.Thr920Ile Uncertain significance Single submitter
- ACIN1 p.Trp2Gly Uncertain significance Single submitter
- ACIN1 p.Val121Glu Uncertain significance Single submitter
- ACIN1 p.Val16Leu Uncertain significance Single submitter
- ACIN1 p.Val23Ala Uncertain significance Single submitter
- ACIN1 p.Val627Leu Uncertain significance Single submitter
- ACIN1 p.Val768Ile Uncertain significance Single submitter
Predictors split 70
The independent predictors disagree with each other — read with care.
- ACIN1 p.Ala1089Thr Uncertain significance Single submitter
- ACIN1 p.Ala39Thr Uncertain significance Single submitter
- ACIN1 p.Arg1044His Uncertain significance Single submitter
- ACIN1 p.Arg1109Trp Uncertain significance Single submitter
- ACIN1 p.Arg1113Gln Uncertain significance Single submitter
- ACIN1 p.Arg1119Gln Uncertain significance Single submitter
- ACIN1 p.Arg1123Cys Uncertain significance Single submitter
- ACIN1 p.Arg1125His Uncertain significance Single submitter
- ACIN1 p.Arg1126Cys Uncertain significance Single submitter
- ACIN1 p.Arg1130Leu Uncertain significance Single submitter
- ACIN1 p.Arg1190Trp Uncertain significance Single submitter
- ACIN1 p.Arg1237Gly Uncertain significance Single submitter
- ACIN1 p.Arg1246Gln Uncertain significance Single submitter
- ACIN1 p.Arg1248Lys Uncertain significance Single submitter
- ACIN1 p.Arg1265His Uncertain significance Single submitter
- ACIN1 p.Arg1277Gln Uncertain significance Single submitter
- ACIN1 p.Arg172Ser Uncertain significance Single submitter
- ACIN1 p.Arg284Gly Uncertain significance Single submitter
- ACIN1 p.Arg3Ile Uncertain significance Single submitter
- ACIN1 p.Arg522Gln Uncertain significance Single submitter
- ACIN1 p.Arg536Cys Uncertain significance Single submitter
- ACIN1 p.Arg544Trp Uncertain significance Single submitter
- ACIN1 p.Arg586Cys Uncertain significance Single submitter
- ACIN1 p.Arg588His Uncertain significance Single submitter
- ACIN1 p.Arg650Cys Uncertain significance Single submitter
- ACIN1 p.Arg743Cys Uncertain significance Single submitter
- ACIN1 p.Arg838Cys Uncertain significance Single submitter
- ACIN1 p.Arg922His Uncertain significance Single submitter
- ACIN1 p.Arg93Cys Uncertain significance Single submitter
- ACIN1 p.Asp842Asn Uncertain significance Single submitter
- ACIN1 p.Gln81Arg Uncertain significance Single submitter
- ACIN1 p.Glu1030Lys Uncertain significance Single submitter
- ACIN1 p.Glu212Asp Uncertain significance Single submitter
- ACIN1 p.Glu221Lys Uncertain significance Single submitter
- ACIN1 p.Glu222Asp Uncertain significance Single submitter
- ACIN1 p.Glu249Asp Uncertain significance Single submitter
- ACIN1 p.Glu249Val Uncertain significance Single submitter
- ACIN1 p.Glu252Ala Uncertain significance Single submitter
- ACIN1 p.Glu300Lys Uncertain significance Single submitter
- ACIN1 p.Glu313Gly Uncertain significance Single submitter
- ACIN1 p.Glu384Lys Uncertain significance Single submitter
- ACIN1 p.Glu6Ala Uncertain significance Single submitter
- ACIN1 p.Gly1039Asp Uncertain significance Single submitter
- ACIN1 p.Gly50Arg Uncertain significance Single submitter
- ACIN1 p.Gly930Arg Uncertain significance Single submitter
- ACIN1 p.Gly975Arg Uncertain significance Single submitter
- ACIN1 p.Ile955Val Uncertain significance Single submitter
- ACIN1 p.Leu309Phe Uncertain significance Single submitter
- ACIN1 p.Leu460His Uncertain significance Single submitter
- ACIN1 p.Lys23Asn Uncertain significance Single submitter
- ACIN1 p.Lys247Asn Uncertain significance Single submitter
- ACIN1 p.Pro1045Thr Uncertain significance Single submitter
- ACIN1 p.Pro388Leu Uncertain significance Single submitter
- ACIN1 p.Pro730His Uncertain significance Single submitter
- ACIN1 p.Pro890Leu Uncertain significance Single submitter
- ACIN1 p.Ser144Trp Uncertain significance Single submitter
- ACIN1 p.Ser18Asn Uncertain significance Single submitter
- ACIN1 p.Ser285Cys Uncertain significance Single submitter
- ACIN1 p.Ser292Cys Uncertain significance Single submitter
- ACIN1 p.Ser328Cys Uncertain significance Single submitter
- ACIN1 p.Ser367Phe Uncertain significance Single submitter
- ACIN1 p.Ser531Cys Uncertain significance Single submitter
- ACIN1 p.Ser756Asn Uncertain significance Single submitter
- ACIN1 p.Ser837Phe Uncertain significance Single submitter
- ACIN1 p.Thr1263Ile Uncertain significance Single submitter
- ACIN1 p.Thr695Asn Uncertain significance Single submitter
- ACIN1 p.Thr718Ala Uncertain significance Single submitter
- ACIN1 p.Thr997Met Uncertain significance Single submitter
- ACIN1 p.Val714Met Uncertain significance Single submitter
- ACIN1 p.Val981Met Uncertain significance Single submitter
All ACIN1 variants
Likely benign 5
- p.Asp1247Glu Single submitter
- p.Gly22= Single submitter
- p.Leu346Gln Single submitter
- p.Pro187Ala Single submitter
- p.Val275= Single submitter
Uncertain significance 168
- c.-18C>T Single submitter ⚠
- c.-23C>A Single submitter ⚠
- p.Ala1089Thr Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala502Val Single submitter ⚠
- p.Ala557Val Single submitter ⚠
- p.Ala735Val Single submitter ⚠
- p.Ala824Val Single submitter ⚠
- p.Arg1044His Single submitter ⚠
- p.Arg1074Gln Single submitter ⚠
- p.Arg1074Trp Single submitter ⚠
- p.Arg1109Trp Single submitter ⚠
- p.Arg1113Gln Single submitter ⚠
- p.Arg1119Gln Single submitter ⚠
- p.Arg1123Cys Single submitter ⚠
- p.Arg1125His Single submitter ⚠
- p.Arg1126Cys Single submitter ⚠
- p.Arg1130Leu Single submitter ⚠
- p.Arg1158Gln Single submitter ⚠
- p.Arg1190Trp Single submitter ⚠
- p.Arg1237Gly Single submitter ⚠
- p.Arg1246Gln Single submitter ⚠
- p.Arg1248Lys Single submitter ⚠
- p.Arg1265His Single submitter ⚠
- p.Arg1277Gln Single submitter ⚠
- p.Arg135Lys Single submitter ⚠
- p.Arg142Ser Single submitter ⚠
- p.Arg14Gln Single submitter ⚠
- p.Arg164Lys Single submitter ⚠
- p.Arg164Thr Single submitter ⚠
- p.Arg168Gly Single submitter ⚠
- p.Arg172Ser Single submitter ⚠
- p.Arg207Gly Single submitter ⚠
- p.Arg284Gly Single submitter ⚠
- p.Arg338Gln Single submitter ⚠
- p.Arg3Ile Single submitter ⚠
- p.Arg500Lys Single submitter ⚠
- p.Arg511Ser Single submitter ⚠
- p.Arg522Gln Single submitter ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg544Trp Single submitter ⚠
- p.Arg580Ser Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg588His Single submitter ⚠
- p.Arg650Cys Single submitter ⚠
- p.Arg650Gly Single submitter ⚠
- p.Arg650His Single submitter ⚠
- p.Arg669Pro Single submitter ⚠
- p.Arg743Cys Single submitter ⚠
- p.Arg743His Single submitter ⚠
- p.Arg838Cys Single submitter ⚠
- p.Arg922His Single submitter ⚠
- p.Arg93Cys Single submitter ⚠
- p.Asn564Asp Single submitter ⚠
- p.Asn593Ser Single submitter ⚠
- p.Asn721Ser Single submitter ⚠
- p.Asn740Ser Single submitter ⚠
- p.Asp400Asn Single submitter ⚠
- p.Asp402Gly Single submitter ⚠
- p.Asp517Asn Single submitter ⚠
- p.Asp742Ala Single submitter ⚠
- p.Asp842Asn Single submitter ⚠
- p.Cys633Phe Single submitter ⚠
- p.Cys633Ser Single submitter ⚠
- p.Gln1145Glu Single submitter ⚠
- p.Gln194Glu Single submitter ⚠
- p.Gln81Arg Single submitter ⚠
- p.Glu1030Lys Single submitter ⚠
- p.Glu1052Asp Single submitter ⚠
- p.Glu1208Ala Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu183Gln Single submitter ⚠
- p.Glu212Asp Single submitter ⚠
- p.Glu221Lys Single submitter ⚠
- p.Glu222Asp Single submitter ⚠
- p.Glu249Asp Single submitter ⚠
- p.Glu249Val Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu252Ala Single submitter ⚠
- p.Glu300Lys Single submitter ⚠
- p.Glu313Gly Single submitter ⚠
- p.Glu348Gln Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu384Lys Single submitter ⚠
- p.Glu3Asp Single submitter ⚠
- p.Glu431Gln Single submitter ⚠
- p.Glu463Gln Single submitter ⚠
- p.Glu477Gly Single submitter ⚠
- p.Glu486Ala Single submitter ⚠
- p.Glu668Gln Single submitter ⚠
- p.Glu681Gln Single submitter ⚠
- p.Glu6Ala Single submitter ⚠
- p.Gly1013Arg Single submitter ⚠
- p.Gly1039Asp Single submitter ⚠
- p.Gly50Arg Single submitter ⚠
- p.Gly619Val Single submitter ⚠
- p.Gly851Glu Single submitter ⚠
- p.Gly930Arg Single submitter ⚠
- p.Gly975Arg Single submitter ⚠
- p.His6Asp Single submitter ⚠
- p.Ile1055Met Single submitter ⚠
- p.Ile380Arg Single submitter ⚠
- p.Ile392Leu Single submitter ⚠
- p.Ile484Val Single submitter ⚠
- p.Ile734Val Single submitter ⚠
- p.Ile952Val Single submitter ⚠
- p.Ile955Val Single submitter ⚠
- p.Ile987Thr Single submitter ⚠
- p.Leu124Arg Single submitter ⚠
- p.Leu309Phe Single submitter ⚠
- p.Leu343Pro Single submitter ⚠
- p.Leu391Ile Single submitter ⚠
- p.Leu445Val Single submitter ⚠
- p.Leu460His Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Leu651Arg Single submitter ⚠
- p.Lys23Asn Single submitter ⚠
- p.Lys247Asn Single submitter ⚠
- p.Lys570Arg Single submitter ⚠
- p.Lys673Gln Single submitter ⚠
- p.Met261Lys Single submitter ⚠
- p.Met261Thr Single submitter ⚠
- p.Met383Ile Single submitter ⚠
- p.Pro1045Thr Single submitter ⚠
- p.Pro1070Leu Single submitter ⚠
- p.Pro197Ser Single submitter ⚠
- p.Pro266Leu Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro357Ser Single submitter ⚠
- p.Pro369Leu Single submitter ⚠
- p.Pro388Leu Single submitter ⚠
- p.Pro508Ser Single submitter ⚠
- p.Pro625Leu Single submitter ⚠
- p.Pro730His Single submitter ⚠
- p.Pro744Thr Single submitter ⚠
- p.Pro890Leu Single submitter ⚠
- p.Ser111Leu Single submitter ⚠
- p.Ser144Trp Single submitter ⚠
- p.Ser185Gly Single submitter ⚠
- p.Ser18Asn Single submitter ⚠
- p.Ser285Cys Single submitter ⚠
- p.Ser292Cys Single submitter ⚠
- p.Ser328Cys Single submitter ⚠
- p.Ser367Phe Single submitter ⚠
- p.Ser376Gly Single submitter ⚠
- p.Ser455Pro Single submitter ⚠
- p.Ser531Cys Single submitter ⚠
- p.Ser606Thr Single submitter ⚠
- p.Ser642Pro Single submitter ⚠
- p.Ser756Asn Single submitter ⚠
- p.Ser757Leu Single submitter ⚠
- p.Ser837Phe Single submitter ⚠
- p.Thr1263Ile Single submitter ⚠
- p.Thr34Ala Single submitter ⚠
- p.Thr611Ala Single submitter ⚠
- p.Thr695Asn Single submitter ⚠
- p.Thr718Ala Single submitter ⚠
- p.Thr772Ile Single submitter ⚠
- p.Thr920Ile Single submitter ⚠
- p.Thr997Met Single submitter ⚠
- p.Trp2Gly Single submitter ⚠
- p.Val121Glu Single submitter ⚠
- p.Val16Leu Single submitter ⚠
- p.Val23Ala Single submitter ⚠
- p.Val627Leu Single submitter ⚠
- p.Val714Met Single submitter ⚠
- p.Val768Ile Single submitter ⚠
- p.Val981Met Single submitter ⚠