ACKR2 — 8 ClinVar variants
All ClinVar germline ACKR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full ACKR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All ACKR2 variants
Uncertain significance 8
- p.Ala248Thr Single submitter ⚠
- p.His317Tyr Single submitter ⚠
- p.Ile56Val Single submitter ⚠
- p.Leu59Trp Single submitter ⚠
- p.Ser172Cys Single submitter ⚠
- p.Ser316Ile Single submitter ⚠
- p.Trp169Ser Single submitter ⚠
- p.Val192Met Single submitter ⚠