ACKR5 — 15 ClinVar variants
All ClinVar germline ACKR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Benign · 1 Likely benign · 13 Uncertain significance
Full ACKR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 8
The independent predictors disagree with each other — read with care.
- ACKR5 p.Arg254Trp Uncertain significance Single submitter
- ACKR5 p.Arg53Cys Uncertain significance Single submitter
- ACKR5 p.Arg53His Uncertain significance Single submitter
- ACKR5 p.Arg84Trp Uncertain significance Single submitter
- ACKR5 p.Phe327Leu Uncertain significance Single submitter
- ACKR5 p.Pro200Ser Uncertain significance Single submitter
- ACKR5 p.Ser181Leu Uncertain significance Single submitter
- ACKR5 p.Val266Ile Uncertain significance Single submitter
All ACKR5 variants
Benign 1
- p.Thr210= Multiple submitters
Likely benign 1
- p.Tyr338= Single submitter
Uncertain significance 13
- p.Ala371Gly Single submitter ⚠
- p.Arg254Trp Single submitter ⚠
- p.Arg53Cys Single submitter ⚠
- p.Arg53His Single submitter ⚠
- p.Arg80Ser Single submitter ⚠
- p.Arg84Trp Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.His284Asn Single submitter ⚠
- p.His376Asn Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Ser181Leu Single submitter ⚠
- p.Val266Ile Single submitter ⚠