ACP3 — 61 ClinVar variants
All ClinVar germline ACP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
2 Benign · 7 Likely benign · 52 Uncertain significance
Full ACP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACP3 p.Ala4Thr Uncertain significance Single submitter
- ACP3 p.Ala9Thr Uncertain significance Single submitter
- ACP3 p.Arg111Gln Uncertain significance Single submitter
- ACP3 p.Arg111Trp Uncertain significance Single submitter
- ACP3 p.Arg159Gly Uncertain significance Single submitter
- ACP3 p.Arg257Ser Uncertain significance Single submitter
- ACP3 p.Arg273Thr Uncertain significance Single submitter
- ACP3 p.Arg28Gly Uncertain significance Single submitter
- ACP3 p.Cys351Ser Uncertain significance Single submitter
- ACP3 p.Cys372Tyr Uncertain significance Single submitter
- ACP3 p.Gln379Lys Uncertain significance Single submitter
- ACP3 p.Gln72Glu Uncertain significance Single submitter
- ACP3 p.Ile188Met Uncertain significance Single submitter
- ACP3 p.Ile50Val Uncertain significance Single submitter
- ACP3 p.Ile58Thr Uncertain significance Single submitter
- ACP3 p.Ile85Thr Uncertain significance Single submitter
- ACP3 p.Leu202Ile Uncertain significance Single submitter
- ACP3 p.Leu213Ser Uncertain significance Single submitter
- ACP3 p.Leu244Gln Uncertain significance Single submitter
- ACP3 p.Lys193Glu Uncertain significance Single submitter
- ACP3 p.Lys322Arg Uncertain significance Single submitter
- ACP3 p.Met117Val Uncertain significance Single submitter
- ACP3 p.Phe24Ser Uncertain significance Single submitter
- ACP3 p.Pro140Leu Uncertain significance Single submitter
- ACP3 p.Pro224Thr Uncertain significance Single submitter
- ACP3 p.Pro5Leu Uncertain significance Single submitter
- ACP3 p.Tyr310Ser Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- ACP3 p.Ala116Ser Uncertain significance Single submitter
- ACP3 p.Ala121Ser Uncertain significance Single submitter
- ACP3 p.Ala311Thr Uncertain significance Single submitter
- ACP3 p.Arg163Cys Uncertain significance Single submitter
- ACP3 p.Arg163His Uncertain significance Single submitter
- ACP3 p.Arg332Gln Uncertain significance Single submitter
- ACP3 p.Arg332Trp Uncertain significance Single submitter
- ACP3 p.Asp211Asn Uncertain significance Single submitter
- ACP3 p.Glu166Lys Uncertain significance Single submitter
- ACP3 p.Glu338Lys Uncertain significance Single submitter
- ACP3 p.Glu60Gln Uncertain significance Single submitter
- ACP3 p.Glu83Gly Uncertain significance Single submitter
- ACP3 p.Gly128Cys Uncertain significance Single submitter
- ACP3 p.Gly305Arg Uncertain significance Single submitter
- ACP3 p.Leu137Ile Uncertain significance Single submitter
- ACP3 p.Leu246Pro Uncertain significance Single submitter
- ACP3 p.Lys36Arg Uncertain significance Single submitter
- ACP3 p.Met117Thr Uncertain significance Single submitter
- ACP3 p.Met75Lys Uncertain significance Single submitter
- ACP3 p.Pro157Ser Uncertain significance Single submitter
- ACP3 p.Thr335Lys Uncertain significance Single submitter
- ACP3 p.Thr370Met Uncertain significance Single submitter
- ACP3 p.Thr52Ile Uncertain significance Single submitter
- ACP3 p.Tyr247Cys Uncertain significance Single submitter
- ACP3 p.Val109Ile Likely benign Single submitter
All ACP3 variants
Benign 2
- p.Asp301Glu Multiple submitters
- p.Gly128= Single submitter
Likely benign 7
- c.121-4T>C Single submitter
- p.Arg236Lys Single submitter
- p.Leu6Val Single submitter
- p.Leu73= Single submitter
- p.Lys173= Single submitter
- p.Tyr280His Single submitter
- p.Val109Ile Single submitter ⚠
Uncertain significance 52
- p.Ala116Ser Single submitter ⚠
- p.Ala121Ser Single submitter ⚠
- p.Ala311Thr Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg111Gln Single submitter ⚠
- p.Arg111Trp Single submitter ⚠
- p.Arg159Gly Single submitter ⚠
- p.Arg163Cys Single submitter ⚠
- p.Arg163His Single submitter ⚠
- p.Arg257Ser Single submitter ⚠
- p.Arg273Thr Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg332Trp Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Cys351Ser Single submitter ⚠
- p.Cys372Tyr Single submitter ⚠
- p.Gln379Lys Single submitter ⚠
- p.Gln72Glu Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu338Lys Single submitter ⚠
- p.Glu60Gln Single submitter ⚠
- p.Glu83Gly Single submitter ⚠
- p.Gly128Cys Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Ile188Met Single submitter ⚠
- p.Ile50Val Single submitter ⚠
- p.Ile58Thr Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu137Ile Single submitter ⚠
- p.Leu202Ile Single submitter ⚠
- p.Leu213Ser Single submitter ⚠
- p.Leu244Gln Single submitter ⚠
- p.Leu246Pro Single submitter ⚠
- p.Lys193Glu Single submitter ⚠
- p.Lys322Arg Single submitter ⚠
- p.Lys36Arg Single submitter ⚠
- p.Met117Thr Single submitter ⚠
- p.Met117Val Single submitter ⚠
- p.Met75Lys Single submitter ⚠
- p.Phe24Ser Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro157Ser Single submitter ⚠
- p.Pro224Thr Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Thr335Lys Single submitter ⚠
- p.Thr370Met Single submitter ⚠
- p.Thr52Ile Single submitter ⚠
- p.Tyr247Cys Single submitter ⚠
- p.Tyr310Ser Single submitter ⚠
- p.Ile284del No assertion criteria mediastinal germ cell tumor