ACRBP — 69 ClinVar variants
All ClinVar germline ACRBP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
3 Likely benign · 66 Uncertain significance
Full ACRBP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACRBP p.Ala192Val Uncertain significance Single submitter
- ACRBP p.Ala244Thr Uncertain significance Single submitter
- ACRBP p.Ala24Thr Uncertain significance Single submitter
- ACRBP p.Ala324Gly Uncertain significance Single submitter
- ACRBP p.Ala345Val Uncertain significance Single submitter
- ACRBP p.Arg110Cys Uncertain significance Single submitter
- ACRBP p.Arg242Gln Uncertain significance Single submitter
- ACRBP p.Arg273Gln Uncertain significance Single submitter
- ACRBP p.Arg290Gln Uncertain significance Single submitter
- ACRBP p.Arg367Gln Uncertain significance Single submitter
- ACRBP p.Arg455Gln Uncertain significance Single submitter
- ACRBP p.Arg502Gln Uncertain significance Single submitter
- ACRBP p.Arg506His Uncertain significance Single submitter
- ACRBP p.Cys104Tyr Uncertain significance Single submitter
- ACRBP p.Gln181Arg Uncertain significance Single submitter
- ACRBP p.Glu139Lys Uncertain significance Single submitter
- ACRBP p.Glu44Gln Uncertain significance Single submitter
- ACRBP p.Glu57Gln Uncertain significance Single submitter
- ACRBP p.Gly188Val Uncertain significance Single submitter
- ACRBP p.Gly237Glu Uncertain significance Single submitter
- ACRBP p.Gly430Glu Uncertain significance Single submitter
- ACRBP p.Gly543Arg Uncertain significance Single submitter
- ACRBP p.His114Asn Uncertain significance Single submitter
- ACRBP p.Leu172Val Uncertain significance Single submitter
- ACRBP p.Leu437Phe Uncertain significance Single submitter
- ACRBP p.Leu537Val Uncertain significance Single submitter
- ACRBP p.Lys239Thr Uncertain significance Single submitter
- ACRBP p.Lys255Gln Uncertain significance Single submitter
- ACRBP p.Lys401Arg Uncertain significance Single submitter
- ACRBP p.Lys503Glu Uncertain significance Single submitter
- ACRBP p.Met282Thr Uncertain significance Single submitter
- ACRBP p.Pro132Ala Uncertain significance Single submitter
- ACRBP p.Pro152Ala Uncertain significance Single submitter
- ACRBP p.Pro169Ala Uncertain significance Single submitter
- ACRBP p.Pro207Arg Uncertain significance Single submitter
- ACRBP p.Pro320Ser Uncertain significance Single submitter
- ACRBP p.Ser141Ala Uncertain significance Single submitter
- ACRBP p.Ser145Leu Uncertain significance Single submitter
- ACRBP p.Ser32Ala Uncertain significance Single submitter
- ACRBP p.Ser359Leu Uncertain significance Single submitter
- ACRBP p.Ser359Pro Uncertain significance Single submitter
- ACRBP p.Ser92Cys Uncertain significance Single submitter
- ACRBP p.Thr278Pro Uncertain significance Single submitter
- ACRBP p.Thr448Ala Uncertain significance Single submitter
- ACRBP p.Thr53Ala Uncertain significance Single submitter
- ACRBP p.Trp308Gly Uncertain significance Single submitter
- ACRBP p.Tyr487Phe Uncertain significance Single submitter
- ACRBP p.Val405Phe Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ACRBP p.Arg162Cys Uncertain significance Single submitter
- ACRBP p.Arg393Gln Uncertain significance Single submitter
- ACRBP p.Arg45Cys Uncertain significance Single submitter
- ACRBP p.Arg500Cys Uncertain significance Single submitter
- ACRBP p.Asn501Lys Uncertain significance Single submitter
- ACRBP p.Gln191His Uncertain significance Single submitter
- ACRBP p.Gln209Arg Uncertain significance Single submitter
- ACRBP p.Glu194Gln Uncertain significance Single submitter
- ACRBP p.Glu202Asp Uncertain significance Single submitter
- ACRBP p.Glu533Asp Uncertain significance Single submitter
- ACRBP p.His195Asn Uncertain significance Single submitter
- ACRBP p.His82Gln Uncertain significance Single submitter
- ACRBP p.Leu539Pro Uncertain significance Single submitter
- ACRBP p.Phe534Leu Uncertain significance Single submitter
- ACRBP p.Pro473Ser Uncertain significance Single submitter
- ACRBP p.Ser185Phe Uncertain significance Single submitter
- ACRBP p.Thr148Met Uncertain significance Single submitter
- ACRBP p.Tyr307Cys Uncertain significance Single submitter
All ACRBP variants
Likely benign 3
- p.Ala6Thr Single submitter
- p.Arg427His Single submitter
- p.His257Gln Single submitter
Uncertain significance 66
- p.Ala192Val Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala24Thr Single submitter ⚠
- p.Ala324Gly Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg455Gln Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Arg500Cys Single submitter ⚠
- p.Arg502Gln Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Asn501Lys Single submitter ⚠
- p.Cys104Tyr Single submitter ⚠
- p.Gln181Arg Single submitter ⚠
- p.Gln191His Single submitter ⚠
- p.Gln209Arg Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu194Gln Single submitter ⚠
- p.Glu202Asp Single submitter ⚠
- p.Glu44Gln Single submitter ⚠
- p.Glu533Asp Single submitter ⚠
- p.Glu57Gln Single submitter ⚠
- p.Gly188Val Single submitter ⚠
- p.Gly237Glu Single submitter ⚠
- p.Gly430Glu Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.His114Asn Single submitter ⚠
- p.His195Asn Single submitter ⚠
- p.His82Gln Single submitter ⚠
- p.Leu172Val Single submitter ⚠
- p.Leu437Phe Single submitter ⚠
- p.Leu537Val Single submitter ⚠
- p.Leu539Pro Single submitter ⚠
- p.Lys239Thr Single submitter ⚠
- p.Lys255Gln Single submitter ⚠
- p.Lys401Arg Single submitter ⚠
- p.Lys503Glu Single submitter ⚠
- p.Met282Thr Single submitter ⚠
- p.Phe534Leu Single submitter ⚠
- p.Pro132Ala Single submitter ⚠
- p.Pro152Ala Single submitter ⚠
- p.Pro169Ala Single submitter ⚠
- p.Pro207Arg Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro473Ser Single submitter ⚠
- p.Ser141Ala Single submitter ⚠
- p.Ser145Leu Single submitter ⚠
- p.Ser185Phe Single submitter ⚠
- p.Ser32Ala Single submitter ⚠
- p.Ser359Leu Single submitter ⚠
- p.Ser359Pro Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Thr148Met Single submitter ⚠
- p.Thr278Pro Single submitter ⚠
- p.Thr448Ala Single submitter ⚠
- p.Thr53Ala Single submitter ⚠
- p.Trp308Gly Single submitter ⚠
- p.Tyr307Cys Single submitter ⚠
- p.Tyr487Phe Single submitter ⚠
- p.Val405Phe Single submitter ⚠