ACRV1 — 26 ClinVar variants
All ClinVar germline ACRV1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Likely benign · 25 Uncertain significance
Full ACRV1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACRV1 p.Ala100Val Uncertain significance Single submitter
- ACRV1 p.Ala169Thr Uncertain significance Single submitter
- ACRV1 p.Ala194Thr Uncertain significance Single submitter
- ACRV1 p.Arg204His Uncertain significance Single submitter
- ACRV1 p.Gln259His Uncertain significance Single submitter
- ACRV1 p.Glu134Gln Uncertain significance Single submitter
- ACRV1 p.Glu97Gly Uncertain significance Single submitter
- ACRV1 p.Gly111Asp Uncertain significance Single submitter
- ACRV1 p.Ile265Thr Uncertain significance Single submitter
- ACRV1 p.Leu124His Uncertain significance Single submitter
- ACRV1 p.Leu124Phe Uncertain significance Single submitter
- ACRV1 p.Leu130Trp Uncertain significance Single submitter
- ACRV1 p.Leu26Ile Uncertain significance Single submitter
- ACRV1 p.Lys77Gln Uncertain significance Single submitter
- ACRV1 p.Pro119Ala Uncertain significance Single submitter
- ACRV1 p.Thr208Ser Uncertain significance Single submitter
- ACRV1 p.Thr58Ile Uncertain significance Single submitter
-
ACRV1 p.Thr208Ile
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 7
The independent predictors disagree with each other — read with care.
- ACRV1 p.Gly14Arg Uncertain significance Single submitter
- ACRV1 p.Gly171Val Uncertain significance Single submitter
- ACRV1 p.His168Tyr Uncertain significance Single submitter
- ACRV1 p.Phe223Cys Uncertain significance Single submitter
- ACRV1 p.Phe223Ser Uncertain significance Single submitter
- ACRV1 p.Ser160Leu Uncertain significance Single submitter
- ACRV1 p.Ser59Cys Uncertain significance Single submitter
All ACRV1 variants
Likely benign 1
- p.Glu42= Single submitter
Uncertain significance 25
- p.Ala100Val Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala194Thr Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Gln259His Single submitter ⚠
- p.Glu134Gln Single submitter ⚠
- p.Glu97Gly Single submitter ⚠
- p.Gly111Asp Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.Gly171Val Single submitter ⚠
- p.His168Tyr Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Leu124His Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Leu130Trp Single submitter ⚠
- p.Leu26Ile Single submitter ⚠
- p.Lys77Gln Single submitter ⚠
- p.Phe223Cys Single submitter ⚠
- p.Phe223Ser Single submitter ⚠
- p.Pro119Ala Single submitter ⚠
- p.Ser160Leu Single submitter ⚠
- p.Ser59Cys Single submitter ⚠
- p.Thr208Ser Single submitter ⚠
- p.Thr58Ile Single submitter ⚠
- p.Thr208Ile No assertion criteria prostate cancer ⚠