ACSL3 — 69 ClinVar variants
All ClinVar germline ACSL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 1 Benign/Likely benign · 4 Likely benign · 62 Uncertain significance
Full ACSL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACSL3 p.Ala544Thr Uncertain significance Single submitter
- ACSL3 p.Arg108His Uncertain significance Single submitter
- ACSL3 p.Arg348Cys Uncertain significance Single submitter
- ACSL3 p.Arg389Gln Uncertain significance Single submitter
- ACSL3 p.Arg435Gln Uncertain significance Single submitter
- ACSL3 p.Arg446Cys Uncertain significance Single submitter
- ACSL3 p.Arg579Gly Uncertain significance Single submitter
- ACSL3 p.Arg637Leu Uncertain significance Single submitter
- ACSL3 p.Asn3Ser Uncertain significance Single submitter
- ACSL3 p.Asp280Gly Uncertain significance Single submitter
- ACSL3 p.Asp696Glu Uncertain significance Single submitter
- ACSL3 p.Gln131Arg Uncertain significance Single submitter
- ACSL3 p.Gln557Arg Uncertain significance Single submitter
- ACSL3 p.Glu46Lys Uncertain significance Single submitter
- ACSL3 p.His27Tyr Uncertain significance Single submitter
- ACSL3 p.His345Asn Uncertain significance Single submitter
- ACSL3 p.Ile162Val Uncertain significance Single submitter
- ACSL3 p.Ile21Val Uncertain significance Single submitter
- ACSL3 p.Ile284Thr Uncertain significance Single submitter
- ACSL3 p.Ile349Val Uncertain significance Single submitter
- ACSL3 p.Ile35Val Uncertain significance Single submitter
- ACSL3 p.Ile465Val Uncertain significance Single submitter
- ACSL3 p.Leu193Ile Uncertain significance Single submitter
- ACSL3 p.Leu508Phe Uncertain significance Single submitter
- ACSL3 p.Met387Ile Uncertain significance Single submitter
- ACSL3 p.Pro570Ser Uncertain significance Single submitter
- ACSL3 p.Ser361Tyr Uncertain significance Single submitter
- ACSL3 p.Thr458Ala Uncertain significance Single submitter
- ACSL3 p.Tyr617His Uncertain significance Single submitter
- ACSL3 p.Val621Phe Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ACSL3 p.Lys265Arg Likely benign Multiple submitters
- ACSL3 p.Ala163Ser Uncertain significance Single submitter
- ACSL3 p.Ala176Val Uncertain significance Single submitter
- ACSL3 p.Ala201Thr Uncertain significance Single submitter
- ACSL3 p.Ala599Val Uncertain significance Single submitter
- ACSL3 p.Arg435Trp Uncertain significance Single submitter
- ACSL3 p.Asn101Ile Uncertain significance Single submitter
- ACSL3 p.Asn303Ser Uncertain significance Single submitter
- ACSL3 p.Gln360Arg Uncertain significance Single submitter
- ACSL3 p.Gln360Glu Uncertain significance Single submitter
- ACSL3 p.Glu171Asp Uncertain significance Single submitter
- ACSL3 p.Glu647Asp Uncertain significance Single submitter
- ACSL3 p.Gly566Ala Uncertain significance Single submitter
- ACSL3 p.His254Arg Uncertain significance Single submitter
- ACSL3 p.His254Leu Uncertain significance Single submitter
- ACSL3 p.Ile123Asn Uncertain significance Single submitter
- ACSL3 p.Ile164Val Uncertain significance Single submitter
- ACSL3 p.Ile21Thr Uncertain significance Single submitter
- ACSL3 p.Ile565Val Uncertain significance Single submitter
- ACSL3 p.Lys96Glu Uncertain significance Single submitter
- ACSL3 p.Met256Val Uncertain significance Single submitter
- ACSL3 p.Phe432Ser Uncertain significance Single submitter
- ACSL3 p.Pro20Arg Uncertain significance Single submitter
- ACSL3 p.Pro354Ser Uncertain significance Single submitter
- ACSL3 p.Pro40Ala Uncertain significance Single submitter
- ACSL3 p.Pro83Ser Uncertain significance Single submitter
- ACSL3 p.Ser337Gly Uncertain significance Single submitter
- ACSL3 p.Ser368Asn Uncertain significance Single submitter
- ACSL3 p.Ser668Pro Uncertain significance Single submitter
- ACSL3 p.Thr458Ile Uncertain significance Single submitter
- ACSL3 p.Tyr33Cys Uncertain significance Single submitter
- ACSL3 p.Tyr82Phe Uncertain significance Single submitter
- ACSL3 p.Val253Met Uncertain significance Single submitter
All ACSL3 variants
Benign/Likely benign 1
- p.Thr11= Multiple submitters
Likely benign 4
- p.Lys265Arg Multiple submitters ⚠
- p.Arg424His Single submitter
- p.Asn425Ser Single submitter
- p.Met268Val Single submitter
Uncertain significance 62
- p.Ala163Ser Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala201Thr Single submitter ⚠
- p.Ala544Thr Single submitter ⚠
- p.Ala599Val Single submitter ⚠
- p.Arg108His Single submitter ⚠
- p.Arg348Cys Single submitter ⚠
- p.Arg389Gln Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Arg435Trp Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg579Gly Single submitter ⚠
- p.Arg637Leu Single submitter ⚠
- p.Asn101Ile Single submitter ⚠
- p.Asn303Ser Single submitter ⚠
- p.Asn3Ser Single submitter ⚠
- p.Asp280Gly Single submitter ⚠
- p.Asp696Glu Single submitter ⚠
- p.Gln131Arg Single submitter ⚠
- p.Gln360Arg Single submitter ⚠
- p.Gln360Glu Single submitter ⚠
- p.Gln557Arg Single submitter ⚠
- p.Glu171Asp Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu647Asp Single submitter ⚠
- p.Gly566Ala Single submitter ⚠
- p.His254Arg Single submitter ⚠
- p.His254Leu Single submitter ⚠
- p.His27Tyr Single submitter ⚠
- p.His345Asn Single submitter ⚠
- p.Ile123Asn Single submitter ⚠
- p.Ile162Val Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile21Thr Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Ile284Thr Single submitter ⚠
- p.Ile349Val Single submitter ⚠
- p.Ile35Val Single submitter ⚠
- p.Ile465Val Single submitter ⚠
- p.Ile565Val Single submitter ⚠
- p.Leu193Ile Single submitter ⚠
- p.Leu508Phe Single submitter ⚠
- p.Lys96Glu Single submitter ⚠
- p.Met256Val Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Phe432Ser Single submitter ⚠
- p.Pro20Arg Single submitter ⚠
- p.Pro354Ser Single submitter ⚠
- p.Pro40Ala Single submitter ⚠
- p.Pro570Ser Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Ser337Gly Single submitter ⚠
- p.Ser361Tyr Single submitter ⚠
- p.Ser368Asn Single submitter ⚠
- p.Ser668Pro Single submitter ⚠
- p.Thr458Ala Single submitter ⚠
- p.Thr458Ile Single submitter ⚠
- p.Tyr33Cys Single submitter ⚠
- p.Tyr617His Single submitter ⚠
- p.Tyr82Phe Single submitter ⚠
- p.Val253Met Single submitter ⚠
- p.Val621Phe Single submitter ⚠