ACSL6 — 83 ClinVar variants
All ClinVar germline ACSL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
4 Benign · 7 Likely benign · 72 Uncertain significance
Full ACSL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACSL6 p.Ala418Ser Uncertain significance Single submitter
- ACSL6 p.Arg212Cys Uncertain significance Single submitter
- ACSL6 p.Arg336Lys Uncertain significance Single submitter
- ACSL6 p.Arg36Gln Uncertain significance Single submitter
- ACSL6 p.Arg397Trp Uncertain significance Single submitter
- ACSL6 p.Arg412Leu Uncertain significance Single submitter
- ACSL6 p.Arg427Gln Uncertain significance Single submitter
- ACSL6 p.Arg48His Uncertain significance Single submitter
- ACSL6 p.Arg604Gln Uncertain significance Single submitter
- ACSL6 p.Asn512His Uncertain significance Single submitter
- ACSL6 p.Asn600Asp Uncertain significance Single submitter
- ACSL6 p.Asp278Asn Uncertain significance Single submitter
- ACSL6 p.Asp278Val Uncertain significance Single submitter
- ACSL6 p.Gln105His Uncertain significance Single submitter
- ACSL6 p.Glu676Gln Uncertain significance Single submitter
- ACSL6 p.Gly267Arg Uncertain significance Single submitter
- ACSL6 p.Gly615Ala Uncertain significance Single submitter
- ACSL6 p.Ile211Val Uncertain significance Single submitter
- ACSL6 p.Ile683Leu Uncertain significance Single submitter
- ACSL6 p.Leu415Gln Uncertain significance Single submitter
- ACSL6 p.Leu509Ile Uncertain significance Single submitter
- ACSL6 p.Lys140Arg Uncertain significance Single submitter
- ACSL6 p.Met350Thr Uncertain significance Single submitter
- ACSL6 p.Phe417Ser Uncertain significance Single submitter
- ACSL6 p.Phe442Cys Uncertain significance Single submitter
- ACSL6 p.Phe69Leu Uncertain significance Single submitter
- ACSL6 p.Pro201Leu Uncertain significance Single submitter
- ACSL6 p.Pro465Ser Uncertain significance Single submitter
- ACSL6 p.Pro697Ala Uncertain significance Single submitter
- ACSL6 p.Ser126Asn Uncertain significance Single submitter
- ACSL6 p.Ser323Leu Uncertain significance Single submitter
- ACSL6 p.Thr171Ser Uncertain significance Single submitter
- ACSL6 p.Thr53Ala Uncertain significance Single submitter
- ACSL6 p.Thr551Met Uncertain significance Single submitter
- ACSL6 p.Tyr483Cys Uncertain significance Single submitter
- ACSL6 p.Tyr544Cys Uncertain significance Single submitter
- ACSL6 p.Val269Asp Uncertain significance Single submitter
- ACSL6 p.Val318Met Uncertain significance Single submitter
- ACSL6 p.Val359Ile Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- ACSL6 p.Ala507Val Uncertain significance Single submitter
- ACSL6 p.Ala609Val Uncertain significance Single submitter
- ACSL6 p.Arg122Cys Uncertain significance Single submitter
- ACSL6 p.Arg122His Uncertain significance Single submitter
- ACSL6 p.Arg182Gln Uncertain significance Single submitter
- ACSL6 p.Arg365His Uncertain significance Single submitter
- ACSL6 p.Arg374His Uncertain significance Single submitter
- ACSL6 p.Arg48Cys Uncertain significance Single submitter
- ACSL6 p.Arg97Gln Uncertain significance Single submitter
- ACSL6 p.Asp434Glu Uncertain significance Single submitter
- ACSL6 p.Glu425Ala Uncertain significance Single submitter
- ACSL6 p.Gly267Trp Uncertain significance Single submitter
- ACSL6 p.Gly429Arg Uncertain significance Single submitter
- ACSL6 p.Gly529Arg Uncertain significance Single submitter
- ACSL6 p.His237Arg Uncertain significance Single submitter
- ACSL6 p.His71Gln Uncertain significance Single submitter
- ACSL6 p.Ile175Met Uncertain significance Single submitter
- ACSL6 p.Ile598Thr Uncertain significance Single submitter
- ACSL6 p.Leu233Arg Uncertain significance Single submitter
- ACSL6 p.Lys656Asn Uncertain significance Single submitter
-
ACSL6 p.Lys668Glu
Uncertain significance
Single submitter
ACSL6-related disorder
- ACSL6 p.Met197Val Uncertain significance Single submitter
- ACSL6 p.Met380Val Uncertain significance Single submitter
- ACSL6 p.Pro289His Uncertain significance Single submitter
- ACSL6 p.Pro289Thr Uncertain significance Single submitter
- ACSL6 p.Pro78Leu Uncertain significance Single submitter
- ACSL6 p.Ser51Leu Uncertain significance Single submitter
- ACSL6 p.Val120Leu Uncertain significance Single submitter
-
ACSL6 p.Val223Met
Uncertain significance
Single submitter
ACSL6-related disorder
- ACSL6 p.Val276Met Uncertain significance Single submitter
- ACSL6 p.Val505Ile Uncertain significance Single submitter
- ACSL6 p.Val623Ile Uncertain significance Single submitter
-
ACSL6 p.Arg412Cys
Likely benign
No assertion criteria
ACSL6-related disorder
All ACSL6 variants
Benign 4
- c.991-9C>G Single submitter
- p.Pro78= Single submitter
- c.865-8C>G No assertion criteria ACSL6-related disorder
- p.Ile566= No assertion criteria ACSL6-related disorder
Likely benign 7
- p.Val56= Single submitter
- p.Ala152= No assertion criteria ACSL6-related disorder
- p.Arg412Cys No assertion criteria ACSL6-related disorder ⚠
- p.Glu17= No assertion criteria ACSL6-related disorder
- p.Thr3= No assertion criteria ACSL6-related disorder
- p.Thr651Ala No assertion criteria ACSL6-related disorder
- p.Val151Met No assertion criteria ACSL6-related disorder
Uncertain significance 72
- p.Ala418Ser Single submitter ⚠
- p.Ala507Val Single submitter ⚠
- p.Ala609Val Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg336Lys Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Arg397Trp Single submitter ⚠
- p.Arg412Leu Single submitter ⚠
- p.Arg427Gln Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg604Gln Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Asn512His Single submitter ⚠
- p.Asn600Asp Single submitter ⚠
- p.Asp278Asn Single submitter ⚠
- p.Asp278Val Single submitter ⚠
- p.Asp434Glu Single submitter ⚠
- p.Gln105His Single submitter ⚠
- p.Glu425Ala Single submitter ⚠
- p.Glu676Gln Single submitter ⚠
- p.Gly267Arg Single submitter ⚠
- p.Gly267Trp Single submitter ⚠
- p.Gly429Arg Single submitter ⚠
- p.Gly529Arg Single submitter ⚠
- p.Gly615Ala Single submitter ⚠
- p.His237Arg Single submitter ⚠
- p.His71Gln Single submitter ⚠
- p.Ile175Met Single submitter ⚠
- p.Ile211Val Single submitter ⚠
- p.Ile598Thr Single submitter ⚠
- p.Ile683Leu Single submitter ⚠
- p.Leu233Arg Single submitter ⚠
- p.Leu415Gln Single submitter ⚠
- p.Leu509Ile Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Lys656Asn Single submitter ⚠
- p.Lys668Glu Single submitter ACSL6-related disorder ⚠
- p.Met197Val Single submitter ⚠
- p.Met26Val Single submitter
- p.Met350Thr Single submitter ⚠
- p.Met380Val Single submitter ⚠
- p.Phe417Ser Single submitter ⚠
- p.Phe442Cys Single submitter ⚠
- p.Phe69Leu Single submitter ⚠
- p.Pro201Leu Single submitter ⚠
- p.Pro289His Single submitter ⚠
- p.Pro289Thr Single submitter ⚠
- p.Pro465Ser Single submitter ⚠
- p.Pro697Ala Single submitter ⚠
- p.Pro78Leu Single submitter ⚠
- p.Ser126Asn Single submitter ⚠
- p.Ser323Leu Single submitter ⚠
- p.Ser51Leu Single submitter ⚠
- p.Thr171Ser Single submitter ⚠
- p.Thr53Ala Single submitter ⚠
- p.Thr551Met Single submitter ⚠
- p.Tyr483Cys Single submitter ⚠
- p.Tyr544Cys Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val223Met Single submitter ACSL6-related disorder ⚠
- p.Val269Asp Single submitter ⚠
- p.Val276Met Single submitter ⚠
- p.Val318Met Single submitter ⚠
- p.Val359Ile Single submitter ⚠
- p.Val505Ile Single submitter ⚠
- p.Val623Ile Single submitter ⚠