ACTR10 — 49 ClinVar variants
All ClinVar germline ACTR10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 48 Uncertain significance
Full ACTR10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTR10 p.Ala229Ser Uncertain significance Single submitter
- ACTR10 p.Ala359Val Uncertain significance Single submitter
- ACTR10 p.Ala363Ser Uncertain significance Single submitter
- ACTR10 p.Arg213Cys Uncertain significance Single submitter
- ACTR10 p.Arg318Ser Uncertain significance Single submitter
- ACTR10 p.Arg87Cys Uncertain significance Single submitter
- ACTR10 p.Asn245Ile Uncertain significance Single submitter
- ACTR10 p.Asn391Ser Uncertain significance Single submitter
- ACTR10 p.Asp186Glu Uncertain significance Single submitter
- ACTR10 p.Gln182Glu Uncertain significance Single submitter
- ACTR10 p.Gln193Arg Uncertain significance Single submitter
- ACTR10 p.Gly132Arg Uncertain significance Single submitter
- ACTR10 p.Gly260Val Uncertain significance Single submitter
- ACTR10 p.His73Asp Uncertain significance Single submitter
- ACTR10 p.Leu288Phe Uncertain significance Single submitter
- ACTR10 p.Met397Ile Uncertain significance Single submitter
- ACTR10 p.Pro292Leu Uncertain significance Single submitter
- ACTR10 p.Pro347Leu Uncertain significance Single submitter
- ACTR10 p.Ser188Asn Uncertain significance Single submitter
- ACTR10 p.Ser310Thr Uncertain significance Single submitter
- ACTR10 p.Thr130Met Uncertain significance Single submitter
- ACTR10 p.Thr214Pro Uncertain significance Single submitter
- ACTR10 p.Tyr248Cys Uncertain significance Single submitter
- ACTR10 p.Val17Leu Uncertain significance Single submitter
- ACTR10 p.Val280Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- ACTR10 p.Ala23Ser Uncertain significance Single submitter
- ACTR10 p.Arg107Cys Uncertain significance Single submitter
- ACTR10 p.Arg222Gln Uncertain significance Single submitter
- ACTR10 p.Arg383Cys Uncertain significance Single submitter
- ACTR10 p.Asp19Glu Uncertain significance Single submitter
- ACTR10 p.Asp234Val Uncertain significance Single submitter
- ACTR10 p.Gly402Arg Uncertain significance Single submitter
- ACTR10 p.Ile293Thr Uncertain significance Single submitter
- ACTR10 p.Leu368Phe Uncertain significance Single submitter
- ACTR10 p.Phe341Leu Uncertain significance Single submitter
- ACTR10 p.Pro203Leu Uncertain significance Single submitter
- ACTR10 p.Pro249Ala Uncertain significance Single submitter
- ACTR10 p.Pro2Gln Uncertain significance Single submitter
- ACTR10 p.Pro330Gln Uncertain significance Single submitter
- ACTR10 p.Pro330Thr Uncertain significance Single submitter
- ACTR10 p.Thr187Lys Uncertain significance Single submitter
- ACTR10 p.Thr381Met Uncertain significance Single submitter
- ACTR10 p.Tyr378Phe Uncertain significance Single submitter
- ACTR10 p.Val55Gly Uncertain significance Single submitter
All ACTR10 variants
Likely benign 1
- p.Ala212Val Single submitter
Uncertain significance 48
- p.Ala229Ser Single submitter ⚠
- p.Ala23Ser Single submitter ⚠
- p.Ala359Val Single submitter ⚠
- p.Ala363Ser Single submitter ⚠
- p.Arg107Cys Single submitter ⚠
- p.Arg213Cys Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg318Ser Single submitter ⚠
- p.Arg383Cys Single submitter ⚠
- p.Arg87Cys Single submitter ⚠
- p.Asn245Ile Single submitter ⚠
- p.Asn391Ser Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp19Glu Single submitter ⚠
- p.Asp234Val Single submitter ⚠
- p.Cys37Tyr Single submitter
- p.Gln182Glu Single submitter ⚠
- p.Gln193Arg Single submitter ⚠
- p.Gly132Arg Single submitter ⚠
- p.Gly260Val Single submitter ⚠
- p.Gly402Arg Single submitter ⚠
- p.Gly6Ser Single submitter
- p.His73Asp Single submitter ⚠
- p.Ile293Thr Single submitter ⚠
- p.Leu288Phe Single submitter ⚠
- p.Leu368Phe Single submitter ⚠
- p.Lys230Thr Single submitter
- p.Met397Ile Single submitter ⚠
- p.Phe341Leu Single submitter ⚠
- p.Pro203Leu Single submitter ⚠
- p.Pro243Ser Single submitter
- p.Pro249Ala Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Pro2Gln Single submitter ⚠
- p.Pro330Gln Single submitter ⚠
- p.Pro330Thr Single submitter ⚠
- p.Pro347Leu Single submitter ⚠
- p.Ser188Asn Single submitter ⚠
- p.Ser310Thr Single submitter ⚠
- p.Thr130Met Single submitter ⚠
- p.Thr187Lys Single submitter ⚠
- p.Thr214Pro Single submitter ⚠
- p.Thr381Met Single submitter ⚠
- p.Tyr248Cys Single submitter ⚠
- p.Tyr378Phe Single submitter ⚠
- p.Val17Leu Single submitter ⚠
- p.Val280Leu Single submitter ⚠
- p.Val55Gly Single submitter ⚠