ACTR5 — 79 ClinVar variants
All ClinVar germline ACTR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
2 Likely benign · 77 Uncertain significance
Full ACTR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTR5 p.Ala11Thr Uncertain significance Single submitter
- ACTR5 p.Ala13Val Uncertain significance Single submitter
- ACTR5 p.Ala14Thr Uncertain significance Single submitter
- ACTR5 p.Ala235Thr Uncertain significance Single submitter
- ACTR5 p.Arg210His Uncertain significance Single submitter
- ACTR5 p.Arg241His Uncertain significance Single submitter
- ACTR5 p.Arg264Gln Uncertain significance Single submitter
- ACTR5 p.Arg297Lys Uncertain significance Single submitter
- ACTR5 p.Arg304Trp Uncertain significance Single submitter
- ACTR5 p.Arg311Gln Uncertain significance Single submitter
- ACTR5 p.Arg312Gln Uncertain significance Single submitter
- ACTR5 p.Arg323Cys Uncertain significance Single submitter
- ACTR5 p.Arg326Gln Uncertain significance Single submitter
- ACTR5 p.Arg518Gly Uncertain significance Single submitter
- ACTR5 p.Arg578Cys Uncertain significance Single submitter
- ACTR5 p.Asn4Lys Uncertain significance Single submitter
- ACTR5 p.Asp532Asn Uncertain significance Single submitter
- ACTR5 p.Gln125Arg Uncertain significance Single submitter
- ACTR5 p.Gln295Glu Uncertain significance Single submitter
- ACTR5 p.Gln301Glu Uncertain significance Single submitter
- ACTR5 p.Glu383Lys Uncertain significance Single submitter
- ACTR5 p.Gly496Asp Uncertain significance Single submitter
- ACTR5 p.Gly536Ser Uncertain significance Single submitter
- ACTR5 p.Gly595Asp Uncertain significance Single submitter
- ACTR5 p.Gly77Ser Uncertain significance Single submitter
- ACTR5 p.Gly81Glu Uncertain significance Single submitter
- ACTR5 p.His274Gln Uncertain significance Single submitter
- ACTR5 p.Leu415Phe Uncertain significance Single submitter
- ACTR5 p.Lys316Arg Uncertain significance Single submitter
- ACTR5 p.Lys374Asn Uncertain significance Single submitter
- ACTR5 p.Met242Val Uncertain significance Single submitter
- ACTR5 p.Met503Ile Uncertain significance Single submitter
- ACTR5 p.Phe169Leu Uncertain significance Single submitter
- ACTR5 p.Pro103Ser Uncertain significance Single submitter
- ACTR5 p.Pro28Ser Uncertain significance Single submitter
- ACTR5 p.Pro30Leu Uncertain significance Single submitter
- ACTR5 p.Pro354Leu Uncertain significance Single submitter
- ACTR5 p.Pro426Ser Uncertain significance Single submitter
- ACTR5 p.Pro49Arg Uncertain significance Single submitter
- ACTR5 p.Pro55Ser Uncertain significance Single submitter
- ACTR5 p.Ser170Thr Uncertain significance Single submitter
- ACTR5 p.Ser76Leu Uncertain significance Single submitter
- ACTR5 p.Ser86Asn Uncertain significance Single submitter
- ACTR5 p.Tyr156Cys Uncertain significance Single submitter
- ACTR5 p.Tyr156His Uncertain significance Single submitter
- ACTR5 p.Val122Asp Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- ACTR5 p.Ala253Thr Uncertain significance Single submitter
- ACTR5 p.Ala371Val Uncertain significance Single submitter
- ACTR5 p.Ala541Gly Uncertain significance Single submitter
- ACTR5 p.Arg450Gln Uncertain significance Single submitter
- ACTR5 p.Arg518Trp Uncertain significance Single submitter
- ACTR5 p.Arg538His Uncertain significance Single submitter
- ACTR5 p.Asn105Ser Uncertain significance Single submitter
- ACTR5 p.Asn309Ser Uncertain significance Single submitter
- ACTR5 p.Asp482Val Uncertain significance Single submitter
- ACTR5 p.Gln524Pro Uncertain significance Single submitter
- ACTR5 p.Glu296Gly Uncertain significance Single submitter
- ACTR5 p.Glu558Lys Uncertain significance Single submitter
- ACTR5 p.Glu56Lys Uncertain significance Single submitter
- ACTR5 p.Gly496Ser Uncertain significance Single submitter
- ACTR5 p.Gly602Asp Uncertain significance Single submitter
- ACTR5 p.His26Tyr Uncertain significance Single submitter
- ACTR5 p.Ile237Val Uncertain significance Single submitter
- ACTR5 p.Leu142Gln Uncertain significance Single submitter
- ACTR5 p.Leu168Phe Uncertain significance Single submitter
- ACTR5 p.Leu90Gln Uncertain significance Single submitter
- ACTR5 p.Lys425Gln Uncertain significance Single submitter
- ACTR5 p.Met242Arg Uncertain significance Single submitter
- ACTR5 p.Pro23Leu Uncertain significance Single submitter
- ACTR5 p.Pro426Leu Uncertain significance Single submitter
- ACTR5 p.Pro49Ser Uncertain significance Single submitter
- ACTR5 p.Ser170Gly Uncertain significance Single submitter
- ACTR5 p.Ser182Gly Uncertain significance Single submitter
- ACTR5 p.Ser365Asn Uncertain significance Single submitter
- ACTR5 p.Ser586Phe Uncertain significance Single submitter
- ACTR5 p.Thr471Ile Uncertain significance Single submitter
- ACTR5 p.Val18Met Uncertain significance Single submitter
All ACTR5 variants
Likely benign 2
- p.Asn381Ser Single submitter
- p.Asn548Asp Single submitter
Uncertain significance 77
- p.Ala11Thr Single submitter ⚠
- p.Ala13Val Single submitter ⚠
- p.Ala14Thr Single submitter ⚠
- p.Ala235Thr Single submitter ⚠
- p.Ala253Thr Single submitter ⚠
- p.Ala371Val Single submitter ⚠
- p.Ala541Gly Single submitter ⚠
- p.Arg210His Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg297Lys Single submitter ⚠
- p.Arg304Trp Single submitter ⚠
- p.Arg311Gln Single submitter ⚠
- p.Arg312Gln Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg450Gln Single submitter ⚠
- p.Arg518Gly Single submitter ⚠
- p.Arg518Trp Single submitter ⚠
- p.Arg538His Single submitter ⚠
- p.Arg578Cys Single submitter ⚠
- p.Asn105Ser Single submitter ⚠
- p.Asn309Ser Single submitter ⚠
- p.Asn4Lys Single submitter ⚠
- p.Asp482Val Single submitter ⚠
- p.Asp532Asn Single submitter ⚠
- p.Gln125Arg Single submitter ⚠
- p.Gln295Glu Single submitter ⚠
- p.Gln301Glu Single submitter ⚠
- p.Gln524Pro Single submitter ⚠
- p.Glu296Gly Single submitter ⚠
- p.Glu383Lys Single submitter ⚠
- p.Glu558Lys Single submitter ⚠
- p.Glu56Lys Single submitter ⚠
- p.Gly496Asp Single submitter ⚠
- p.Gly496Ser Single submitter ⚠
- p.Gly536Ser Single submitter ⚠
- p.Gly595Asp Single submitter ⚠
- p.Gly602Asp Single submitter ⚠
- p.Gly77Ser Single submitter ⚠
- p.Gly81Glu Single submitter ⚠
- p.His26Tyr Single submitter ⚠
- p.His274Gln Single submitter ⚠
- p.Ile237Val Single submitter ⚠
- p.Leu142Gln Single submitter ⚠
- p.Leu168Phe Single submitter ⚠
- p.Leu415Phe Single submitter ⚠
- p.Leu90Gln Single submitter ⚠
- p.Lys316Arg Single submitter ⚠
- p.Lys374Asn Single submitter ⚠
- p.Lys425Gln Single submitter ⚠
- p.Met242Arg Single submitter ⚠
- p.Met242Val Single submitter ⚠
- p.Met503Ile Single submitter ⚠
- p.Phe169Leu Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro426Ser Single submitter ⚠
- p.Pro49Arg Single submitter ⚠
- p.Pro49Ser Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Ser170Gly Single submitter ⚠
- p.Ser170Thr Single submitter ⚠
- p.Ser182Gly Single submitter ⚠
- p.Ser365Asn Single submitter ⚠
- p.Ser586Phe Single submitter ⚠
- p.Ser76Leu Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Thr471Ile Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Tyr156His Single submitter ⚠
- p.Val122Asp Single submitter ⚠
- p.Val18Met Single submitter ⚠