ACTR8 — 80 ClinVar variants
All ClinVar germline ACTR8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Benign · 79 Uncertain significance
Full ACTR8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTR8 p.Ala427Ser Uncertain significance Single submitter
- ACTR8 p.Ala483Val Uncertain significance Single submitter
- ACTR8 p.Ala593Pro Uncertain significance Single submitter
- ACTR8 p.Ala621Ser Uncertain significance Single submitter
- ACTR8 p.Arg128His Uncertain significance Single submitter
- ACTR8 p.Arg144Gln Uncertain significance Single submitter
- ACTR8 p.Arg554Gly Uncertain significance Single submitter
- ACTR8 p.Arg614Cys Uncertain significance Single submitter
- ACTR8 p.Arg614Ser Uncertain significance Single submitter
- ACTR8 p.Asn108Ser Uncertain significance Single submitter
- ACTR8 p.Asn124Asp Uncertain significance Single submitter
- ACTR8 p.Asn140Ile Uncertain significance Single submitter
- ACTR8 p.Asn175Ser Uncertain significance Single submitter
- ACTR8 p.Asn557His Uncertain significance Single submitter
- ACTR8 p.Asp149Gly Uncertain significance Single submitter
- ACTR8 p.Asp238Gly Uncertain significance Single submitter
- ACTR8 p.Asp418Val Uncertain significance Single submitter
- ACTR8 p.Asp486Asn Uncertain significance Single submitter
- ACTR8 p.Asp486His Uncertain significance Single submitter
- ACTR8 p.Gln477Glu Uncertain significance Single submitter
- ACTR8 p.Gly275Ser Uncertain significance Single submitter
- ACTR8 p.Gly326Val Uncertain significance Single submitter
- ACTR8 p.Gly478Ala Uncertain significance Single submitter
- ACTR8 p.Gly510Asp Uncertain significance Single submitter
- ACTR8 p.Ile239Phe Uncertain significance Single submitter
- ACTR8 p.Leu516Arg Uncertain significance Single submitter
- ACTR8 p.Leu58Ser Uncertain significance Single submitter
- ACTR8 p.Lys347Thr Uncertain significance Single submitter
- ACTR8 p.Lys88Glu Uncertain significance Single submitter
- ACTR8 p.Met495Val Uncertain significance Single submitter
- ACTR8 p.Pro133Ala Uncertain significance Single submitter
- ACTR8 p.Pro389Ser Uncertain significance Single submitter
- ACTR8 p.Pro68Ala Uncertain significance Single submitter
- ACTR8 p.Ser152Leu Uncertain significance Single submitter
- ACTR8 p.Ser277Arg Uncertain significance Single submitter
- ACTR8 p.Ser475Thr Uncertain significance Single submitter
- ACTR8 p.Tyr139Ser Uncertain significance Single submitter
- ACTR8 p.Tyr180Cys Uncertain significance Single submitter
- ACTR8 p.Val174Gly Uncertain significance Single submitter
- ACTR8 p.Val538Gly Uncertain significance Single submitter
- ACTR8 p.Val623Leu Uncertain significance Single submitter
- ACTR8 p.Val623Met Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- ACTR8 p.Ala171Ser Uncertain significance Single submitter
- ACTR8 p.Ala270Thr Uncertain significance Single submitter
- ACTR8 p.Ala388Ser Uncertain significance Single submitter
- ACTR8 p.Ala436Glu Uncertain significance Single submitter
- ACTR8 p.Ala585Pro Uncertain significance Single submitter
- ACTR8 p.Arg137Cys Uncertain significance Single submitter
- ACTR8 p.Arg137His Uncertain significance Single submitter
- ACTR8 p.Arg301Gln Uncertain significance Single submitter
- ACTR8 p.Arg301Trp Uncertain significance Single submitter
- ACTR8 p.Arg324Gln Uncertain significance Single submitter
- ACTR8 p.Arg582Trp Uncertain significance Single submitter
- ACTR8 p.Arg610His Uncertain significance Single submitter
- ACTR8 p.Arg77Gln Uncertain significance Single submitter
- ACTR8 p.Asp421Asn Uncertain significance Single submitter
- ACTR8 p.Asp65Asn Uncertain significance Single submitter
- ACTR8 p.Cys594Gly Uncertain significance Single submitter
- ACTR8 p.Gln605His Uncertain significance Single submitter
- ACTR8 p.Glu14Asp Uncertain significance Single submitter
- ACTR8 p.Glu169Gly Uncertain significance Single submitter
- ACTR8 p.Glu549Gly Uncertain significance Single submitter
- ACTR8 p.Gly96Arg Uncertain significance Single submitter
- ACTR8 p.His363Arg Uncertain significance Single submitter
- ACTR8 p.Ile584Met Uncertain significance Single submitter
- ACTR8 p.Leu220Phe Uncertain significance Single submitter
- ACTR8 p.Pro197Leu Uncertain significance Single submitter
- ACTR8 p.Ser138Cys Uncertain significance Single submitter
- ACTR8 p.Ser152Trp Uncertain significance Single submitter
- ACTR8 p.Ser372Cys Uncertain significance Single submitter
- ACTR8 p.Ser460Phe Uncertain significance Single submitter
- ACTR8 p.Thr157Ala Uncertain significance Single submitter
- ACTR8 p.Thr202Lys Uncertain significance Single submitter
- ACTR8 p.Thr271Ser Uncertain significance Single submitter
- ACTR8 p.Thr335Ala Uncertain significance Single submitter
- ACTR8 p.Val284Ile Uncertain significance Single submitter
- ACTR8 p.Val298Met Uncertain significance Single submitter
- ACTR8 p.Val613Ile Uncertain significance Single submitter
- ACTR8 p.Val74Ile Uncertain significance Single submitter
All ACTR8 variants
Benign 1
- c.406-7T>G Multiple submitters
Uncertain significance 79
- p.Ala171Ser Single submitter ⚠
- p.Ala270Thr Single submitter ⚠
- p.Ala388Ser Single submitter ⚠
- p.Ala427Ser Single submitter ⚠
- p.Ala436Glu Single submitter ⚠
- p.Ala483Val Single submitter ⚠
- p.Ala585Pro Single submitter ⚠
- p.Ala593Pro Single submitter ⚠
- p.Ala621Ser Single submitter ⚠
- p.Arg128His Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg301Trp Single submitter ⚠
- p.Arg324Gln Single submitter ⚠
- p.Arg554Gly Single submitter ⚠
- p.Arg582Trp Single submitter ⚠
- p.Arg610His Single submitter ⚠
- p.Arg614Cys Single submitter ⚠
- p.Arg614Ser Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asn108Ser Single submitter ⚠
- p.Asn124Asp Single submitter ⚠
- p.Asn140Ile Single submitter ⚠
- p.Asn175Ser Single submitter ⚠
- p.Asn557His Single submitter ⚠
- p.Asp149Gly Single submitter ⚠
- p.Asp238Gly Single submitter ⚠
- p.Asp418Val Single submitter ⚠
- p.Asp421Asn Single submitter ⚠
- p.Asp486Asn Single submitter ⚠
- p.Asp486His Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Cys594Gly Single submitter ⚠
- p.Gln477Glu Single submitter ⚠
- p.Gln605His Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Glu169Gly Single submitter ⚠
- p.Glu549Gly Single submitter ⚠
- p.Gly275Ser Single submitter ⚠
- p.Gly326Val Single submitter ⚠
- p.Gly478Ala Single submitter ⚠
- p.Gly510Asp Single submitter ⚠
- p.Gly96Arg Single submitter ⚠
- p.His363Arg Single submitter ⚠
- p.Ile239Phe Single submitter ⚠
- p.Ile584Met Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Leu516Arg Single submitter ⚠
- p.Leu58Ser Single submitter ⚠
- p.Lys347Thr Single submitter ⚠
- p.Lys88Glu Single submitter ⚠
- p.Met495Val Single submitter ⚠
- p.Pro133Ala Single submitter ⚠
- p.Pro197Leu Single submitter ⚠
- p.Pro389Ser Single submitter ⚠
- p.Pro68Ala Single submitter ⚠
- p.Ser138Cys Single submitter ⚠
- p.Ser152Leu Single submitter ⚠
- p.Ser152Trp Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Ser372Cys Single submitter ⚠
- p.Ser460Phe Single submitter ⚠
- p.Ser475Thr Single submitter ⚠
- p.Thr157Ala Single submitter ⚠
- p.Thr202Lys Single submitter ⚠
- p.Thr271Ser Single submitter ⚠
- p.Thr335Ala Single submitter ⚠
- p.Tyr139Ser Single submitter ⚠
- p.Tyr180Cys Single submitter ⚠
- p.Val174Gly Single submitter ⚠
- p.Val284Ile Single submitter ⚠
- p.Val298Met Single submitter ⚠
- p.Val538Gly Single submitter ⚠
- p.Val613Ile Single submitter ⚠
- p.Val623Leu Single submitter ⚠
- p.Val623Met Single submitter ⚠
- p.Val74Ile Single submitter ⚠