ACTRT3 — 65 ClinVar variants
All ClinVar germline ACTRT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Likely benign · 64 Uncertain significance
Full ACTRT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ACTRT3 p.Ala108Val Uncertain significance Single submitter
- ACTRT3 p.Ala257Val Uncertain significance Single submitter
- ACTRT3 p.Ala315Val Uncertain significance Single submitter
- ACTRT3 p.Ala323Thr Uncertain significance Single submitter
- ACTRT3 p.Arg309Trp Uncertain significance Single submitter
- ACTRT3 p.Arg43His Uncertain significance Single submitter
- ACTRT3 p.Arg43Ser Uncertain significance Single submitter
- ACTRT3 p.Asp204Glu Uncertain significance Single submitter
- ACTRT3 p.Asp307Gly Uncertain significance Single submitter
- ACTRT3 p.Asp351Gly Uncertain significance Single submitter
- ACTRT3 p.Cys232Tyr Uncertain significance Single submitter
- ACTRT3 p.Cys371Tyr Uncertain significance Single submitter
- ACTRT3 p.Gln250Glu Uncertain significance Single submitter
- ACTRT3 p.Gln325Glu Uncertain significance Single submitter
- ACTRT3 p.Gly23Val Uncertain significance Single submitter
- ACTRT3 p.Gly48Arg Uncertain significance Single submitter
- ACTRT3 p.Gly48Val Uncertain significance Single submitter
- ACTRT3 p.Ile245Thr Uncertain significance Single submitter
- ACTRT3 p.Ile279Lys Uncertain significance Single submitter
- ACTRT3 p.Ile327Val Uncertain significance Single submitter
- ACTRT3 p.Ile366Arg Uncertain significance Single submitter
- ACTRT3 p.Ile83Thr Uncertain significance Single submitter
- ACTRT3 p.Leu200Phe Uncertain significance Single submitter
- ACTRT3 p.Leu233Val Uncertain significance Single submitter
- ACTRT3 p.Leu247Ile Uncertain significance Single submitter
- ACTRT3 p.Lys94Asn Uncertain significance Single submitter
- ACTRT3 p.Met133Thr Uncertain significance Single submitter
- ACTRT3 p.Met198Val Uncertain significance Single submitter
- ACTRT3 p.Met226Arg Uncertain significance Single submitter
- ACTRT3 p.Met338Thr Uncertain significance Single submitter
- ACTRT3 p.Pro261Leu Uncertain significance Single submitter
- ACTRT3 p.Ser260Tyr Uncertain significance Single submitter
- ACTRT3 p.Ser63Leu Uncertain significance Single submitter
- ACTRT3 p.Ser77Pro Uncertain significance Single submitter
- ACTRT3 p.Thr148Ile Uncertain significance Single submitter
- ACTRT3 p.Thr185Ile Uncertain significance Single submitter
- ACTRT3 p.Thr284Ile Uncertain significance Single submitter
- ACTRT3 p.Val362Ala Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- ACTRT3 p.Ala318Ser Uncertain significance Single submitter
- ACTRT3 p.Arg205Ser Uncertain significance Single submitter
- ACTRT3 p.Arg25Trp Uncertain significance Single submitter
- ACTRT3 p.Arg370Ile Uncertain significance Single submitter
- ACTRT3 p.Arg37Gly Uncertain significance Single submitter
- ACTRT3 p.Arg37His Uncertain significance Single submitter
- ACTRT3 p.Arg37Leu Likely benign Single submitter
- ACTRT3 p.Asp204Gly Uncertain significance Single submitter
- ACTRT3 p.Asp231His Uncertain significance Single submitter
- ACTRT3 p.Glu166Gln Uncertain significance Single submitter
- ACTRT3 p.Glu224Asp Uncertain significance Single submitter
- ACTRT3 p.Glu267Lys Uncertain significance Single submitter
- ACTRT3 p.Glu82Val Uncertain significance Single submitter
- ACTRT3 p.Ile274Val Uncertain significance Single submitter
- ACTRT3 p.Ile294Val Uncertain significance Single submitter
- ACTRT3 p.Leu103Phe Uncertain significance Single submitter
- ACTRT3 p.Leu103Val Uncertain significance Single submitter
- ACTRT3 p.Leu51Arg Uncertain significance Single submitter
- ACTRT3 p.Met192Ile Uncertain significance Single submitter
- ACTRT3 p.Pro329Ala Uncertain significance Single submitter
- ACTRT3 p.Pro32Leu Uncertain significance Single submitter
- ACTRT3 p.Pro364Ser Uncertain significance Single submitter
- ACTRT3 p.Ser347Cys Uncertain significance Single submitter
- ACTRT3 p.Thr148Asn Uncertain significance Single submitter
- ACTRT3 p.Thr301Ile Uncertain significance Single submitter
- ACTRT3 p.Tyr132Cys Uncertain significance Single submitter
- ACTRT3 p.Val311Phe Uncertain significance Single submitter
All ACTRT3 variants
Likely benign 1
- p.Arg37Leu Single submitter ⚠
Uncertain significance 64
- p.Ala108Val Single submitter ⚠
- p.Ala257Val Single submitter ⚠
- p.Ala315Val Single submitter ⚠
- p.Ala318Ser Single submitter ⚠
- p.Ala323Thr Single submitter ⚠
- p.Arg205Ser Single submitter ⚠
- p.Arg25Trp Single submitter ⚠
- p.Arg309Trp Single submitter ⚠
- p.Arg370Ile Single submitter ⚠
- p.Arg37Gly Single submitter ⚠
- p.Arg37His Single submitter ⚠
- p.Arg43His Single submitter ⚠
- p.Arg43Ser Single submitter ⚠
- p.Asp204Glu Single submitter ⚠
- p.Asp204Gly Single submitter ⚠
- p.Asp231His Single submitter ⚠
- p.Asp307Gly Single submitter ⚠
- p.Asp351Gly Single submitter ⚠
- p.Cys232Tyr Single submitter ⚠
- p.Cys371Tyr Single submitter ⚠
- p.Gln250Glu Single submitter ⚠
- p.Gln325Glu Single submitter ⚠
- p.Glu166Gln Single submitter ⚠
- p.Glu224Asp Single submitter ⚠
- p.Glu267Lys Single submitter ⚠
- p.Glu82Val Single submitter ⚠
- p.Gly23Val Single submitter ⚠
- p.Gly48Arg Single submitter ⚠
- p.Gly48Val Single submitter ⚠
- p.Ile245Thr Single submitter ⚠
- p.Ile274Val Single submitter ⚠
- p.Ile279Lys Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile327Val Single submitter ⚠
- p.Ile366Arg Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Leu103Phe Single submitter ⚠
- p.Leu103Val Single submitter ⚠
- p.Leu200Phe Single submitter ⚠
- p.Leu233Val Single submitter ⚠
- p.Leu247Ile Single submitter ⚠
- p.Leu51Arg Single submitter ⚠
- p.Lys94Asn Single submitter ⚠
- p.Met133Thr Single submitter ⚠
- p.Met192Ile Single submitter ⚠
- p.Met198Val Single submitter ⚠
- p.Met226Arg Single submitter ⚠
- p.Met338Thr Single submitter ⚠
- p.Pro261Leu Single submitter ⚠
- p.Pro329Ala Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro364Ser Single submitter ⚠
- p.Ser260Tyr Single submitter ⚠
- p.Ser347Cys Single submitter ⚠
- p.Ser63Leu Single submitter ⚠
- p.Ser77Pro Single submitter ⚠
- p.Thr148Asn Single submitter ⚠
- p.Thr148Ile Single submitter ⚠
- p.Thr185Ile Single submitter ⚠
- p.Thr284Ile Single submitter ⚠
- p.Thr301Ile Single submitter ⚠
- p.Tyr132Cys Single submitter ⚠
- p.Val311Phe Single submitter ⚠
- p.Val362Ala Single submitter ⚠