ADAD1 — 63 ClinVar variants
All ClinVar germline ADAD1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Likely benign · 62 Uncertain significance
Full ADAD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAD1 p.Ala183Val Uncertain significance Single submitter
- ADAD1 p.Ala352Thr Uncertain significance Single submitter
- ADAD1 p.Arg216Ser Uncertain significance Single submitter
- ADAD1 p.Arg279Lys Uncertain significance Single submitter
- ADAD1 p.Arg508Trp Uncertain significance Single submitter
- ADAD1 p.Asn256Ser Uncertain significance Single submitter
- ADAD1 p.Asn378Ser Uncertain significance Single submitter
- ADAD1 p.Asn5Ser Uncertain significance Single submitter
- ADAD1 p.Gln464Arg Uncertain significance Single submitter
- ADAD1 p.Gln9Arg Uncertain significance Single submitter
- ADAD1 p.Glu200Gly Uncertain significance Single submitter
- ADAD1 p.Glu254Gln Uncertain significance Single submitter
- ADAD1 p.Glu393Asp Uncertain significance Single submitter
- ADAD1 p.Ile204Thr Uncertain significance Single submitter
- ADAD1 p.Ile209Val Uncertain significance Single submitter
- ADAD1 p.Ile347Val Uncertain significance Single submitter
- ADAD1 p.Ile571Thr Uncertain significance Single submitter
- ADAD1 p.Leu101Phe Uncertain significance Single submitter
- ADAD1 p.Leu268Ser Uncertain significance Single submitter
- ADAD1 p.Lys262Thr Uncertain significance Single submitter
- ADAD1 p.Lys31Glu Uncertain significance Single submitter
- ADAD1 p.Lys81Arg Uncertain significance Single submitter
- ADAD1 p.Met576Lys Uncertain significance Single submitter
- ADAD1 p.Met576Val Uncertain significance Single submitter
- ADAD1 p.Phe305Val Uncertain significance Single submitter
- ADAD1 p.Pro36Arg Uncertain significance Single submitter
- ADAD1 p.Pro63Ser Uncertain significance Single submitter
- ADAD1 p.Ser225Leu Uncertain significance Single submitter
- ADAD1 p.Ser333Thr Uncertain significance Single submitter
- ADAD1 p.Ser403Asn Uncertain significance Single submitter
- ADAD1 p.Ser455Gly Uncertain significance Single submitter
- ADAD1 p.Thr119Ala Uncertain significance Single submitter
- ADAD1 p.Thr175Arg Uncertain significance Single submitter
- ADAD1 p.Thr276Ala Uncertain significance Single submitter
- ADAD1 p.Thr30Lys Uncertain significance Single submitter
- ADAD1 p.Thr424Ile Uncertain significance Single submitter
- ADAD1 p.Tyr255Ser Uncertain significance Single submitter
- ADAD1 p.Val247Gly Uncertain significance Single submitter
- ADAD1 p.Val267Leu Uncertain significance Single submitter
- ADAD1 p.Val274Leu Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- ADAD1 p.Ala430Thr Uncertain significance Single submitter
- ADAD1 p.Ala460Thr Uncertain significance Single submitter
- ADAD1 p.Arg517Gln Uncertain significance Single submitter
- ADAD1 p.Arg92Cys Uncertain significance Single submitter
- ADAD1 p.Arg92His Uncertain significance Single submitter
- ADAD1 p.Glu547Lys Uncertain significance Single submitter
- ADAD1 p.Leu20Pro Uncertain significance Single submitter
- ADAD1 p.Leu313Val Uncertain significance Single submitter
- ADAD1 p.Lys331Glu Uncertain significance Single submitter
- ADAD1 p.Lys89Thr Uncertain significance Single submitter
- ADAD1 p.Met107Ile Uncertain significance Single submitter
- ADAD1 p.Met299Thr Uncertain significance Single submitter
- ADAD1 p.Pro178Arg Uncertain significance Single submitter
- ADAD1 p.Pro180Arg Uncertain significance Single submitter
- ADAD1 p.Ser15Asn Uncertain significance Single submitter
- ADAD1 p.Ser311Cys Uncertain significance Single submitter
- ADAD1 p.Ser40Phe Uncertain significance Single submitter
- ADAD1 p.Ser473Gly Uncertain significance Single submitter
- ADAD1 p.Ser516Asn Uncertain significance Single submitter
- ADAD1 p.Tyr555Cys Uncertain significance Single submitter
- ADAD1 p.Val213Ile Uncertain significance Single submitter
- ADAD1 p.Val360Met Uncertain significance Single submitter
All ADAD1 variants
Likely benign 1
- p.Arg283= Single submitter
Uncertain significance 62
- p.Ala183Val Single submitter ⚠
- p.Ala352Thr Single submitter ⚠
- p.Ala430Thr Single submitter ⚠
- p.Ala460Thr Single submitter ⚠
- p.Arg216Ser Single submitter ⚠
- p.Arg279Lys Single submitter ⚠
- p.Arg508Trp Single submitter ⚠
- p.Arg517Gln Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asn256Ser Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asn5Ser Single submitter ⚠
- p.Gln464Arg Single submitter ⚠
- p.Gln9Arg Single submitter ⚠
- p.Glu200Gly Single submitter ⚠
- p.Glu254Gln Single submitter ⚠
- p.Glu393Asp Single submitter ⚠
- p.Glu547Lys Single submitter ⚠
- p.Ile204Thr Single submitter ⚠
- p.Ile209Val Single submitter ⚠
- p.Ile347Val Single submitter ⚠
- p.Ile571Thr Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Leu268Ser Single submitter ⚠
- p.Leu313Val Single submitter ⚠
- p.Lys262Thr Single submitter ⚠
- p.Lys31Glu Single submitter ⚠
- p.Lys331Glu Single submitter ⚠
- p.Lys81Arg Single submitter ⚠
- p.Lys89Thr Single submitter ⚠
- p.Met107Ile Single submitter ⚠
- p.Met299Thr Single submitter ⚠
- p.Met576Lys Single submitter ⚠
- p.Met576Val Single submitter ⚠
- p.Phe305Val Single submitter ⚠
- p.Pro178Arg Single submitter ⚠
- p.Pro180Arg Single submitter ⚠
- p.Pro36Arg Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Ser15Asn Single submitter ⚠
- p.Ser225Leu Single submitter ⚠
- p.Ser311Cys Single submitter ⚠
- p.Ser333Thr Single submitter ⚠
- p.Ser403Asn Single submitter ⚠
- p.Ser40Phe Single submitter ⚠
- p.Ser455Gly Single submitter ⚠
- p.Ser473Gly Single submitter ⚠
- p.Ser516Asn Single submitter ⚠
- p.Thr119Ala Single submitter ⚠
- p.Thr175Arg Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Thr30Lys Single submitter ⚠
- p.Thr424Ile Single submitter ⚠
- p.Tyr255Ser Single submitter ⚠
- p.Tyr555Cys Single submitter ⚠
- p.Val213Ile Single submitter ⚠
- p.Val247Gly Single submitter ⚠
- p.Val267Leu Single submitter ⚠
- p.Val274Leu Single submitter ⚠
- p.Val360Met Single submitter ⚠