ADAD2 — 178 ClinVar variants
All ClinVar germline ADAD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 154 flagged for review →
1 Pathogenic · 16 Likely benign · 161 Uncertain significance
Full ADAD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 154
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 89
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAD2 p.Ala198Val Uncertain significance Single submitter
- ADAD2 p.Ala20Gly Uncertain significance Single submitter
- ADAD2 p.Ala396Val Uncertain significance Single submitter
- ADAD2 p.Ala401Glu Uncertain significance Single submitter
- ADAD2 p.Ala42Ser Uncertain significance Single submitter
- ADAD2 p.Ala463Val Uncertain significance Single submitter
- ADAD2 p.Ala46Ser Uncertain significance Single submitter
- ADAD2 p.Ala4Val Uncertain significance Single submitter
- ADAD2 p.Ala50Thr Uncertain significance Single submitter
- ADAD2 p.Ala511Val Uncertain significance Single submitter
- ADAD2 p.Ala571Pro Uncertain significance Single submitter
- ADAD2 p.Ala80Pro Uncertain significance Single submitter
- ADAD2 p.Ala8Pro Uncertain significance Single submitter
- ADAD2 p.Arg250Gly Uncertain significance Single submitter
- ADAD2 p.Arg290Gly Uncertain significance Single submitter
- ADAD2 p.Arg33Gln Uncertain significance Single submitter
- ADAD2 p.Arg33Leu Uncertain significance Single submitter
- ADAD2 p.Arg348Gly Uncertain significance Single submitter
- ADAD2 p.Arg348Ser Uncertain significance Single submitter
- ADAD2 p.Arg367His Uncertain significance Single submitter
- ADAD2 p.Arg483Gly Uncertain significance Single submitter
- ADAD2 p.Arg525Gly Uncertain significance Single submitter
- ADAD2 p.Arg525Leu Uncertain significance Single submitter
- ADAD2 p.Asn341Ser Uncertain significance Single submitter
- ADAD2 p.Cys177Tyr Uncertain significance Single submitter
- ADAD2 p.Cys454Phe Uncertain significance Single submitter
- ADAD2 p.Gln115Leu Uncertain significance Single submitter
- ADAD2 p.Gln24His Uncertain significance Single submitter
- ADAD2 p.Gln278Leu Uncertain significance Single submitter
- ADAD2 p.Gln369Arg Uncertain significance Single submitter
- ADAD2 p.Gln375His Uncertain significance Single submitter
- ADAD2 p.Gln40Pro Uncertain significance Single submitter
- ADAD2 p.Gln554Glu Uncertain significance Single submitter
- ADAD2 p.Gln559His Uncertain significance Single submitter
- ADAD2 p.Gln90Glu Uncertain significance Single submitter
- ADAD2 p.Glu226Lys Uncertain significance Single submitter
- ADAD2 p.Glu313Lys Uncertain significance Single submitter
- ADAD2 p.Glu476Lys Uncertain significance Single submitter
- ADAD2 p.Glu497Lys Uncertain significance Single submitter
- ADAD2 p.Glu546Gln Uncertain significance Single submitter
- ADAD2 p.Gly103Val Uncertain significance Single submitter
- ADAD2 p.Gly219Ser Uncertain significance Single submitter
- ADAD2 p.Gly409Ser Uncertain significance Single submitter
- ADAD2 p.Gly469Glu Uncertain significance Single submitter
- ADAD2 p.Gly492Arg Uncertain significance Single submitter
- ADAD2 p.Gly68Glu Uncertain significance Single submitter
- ADAD2 p.Gly7Val Uncertain significance Single submitter
- ADAD2 p.Gly88Glu Uncertain significance Single submitter
- ADAD2 p.His362Gln Uncertain significance Single submitter
- ADAD2 p.Ile205Leu Uncertain significance Single submitter
- ADAD2 p.Ile246Leu Uncertain significance Single submitter
- ADAD2 p.Leu104Pro Uncertain significance Single submitter
- ADAD2 p.Leu427Val Uncertain significance Single submitter
- ADAD2 p.Leu464Pro Uncertain significance Single submitter
- ADAD2 p.Leu491Met Uncertain significance Single submitter
- ADAD2 p.Leu87Val Uncertain significance Single submitter
- ADAD2 p.Lys109Arg Uncertain significance Single submitter
- ADAD2 p.Lys330Asn Uncertain significance Single submitter
- ADAD2 p.Lys549Glu Uncertain significance Single submitter
- ADAD2 p.Met91Ile Uncertain significance Single submitter
- ADAD2 p.Met91Thr Uncertain significance Single submitter
- ADAD2 p.Phe327Leu Uncertain significance Single submitter
- ADAD2 p.Pro100Arg Uncertain significance Single submitter
- ADAD2 p.Pro100Ser Uncertain significance Single submitter
- ADAD2 p.Pro144Arg Uncertain significance Single submitter
- ADAD2 p.Pro157Arg Uncertain significance Single submitter
- ADAD2 p.Pro196Ala Uncertain significance Single submitter
- ADAD2 p.Pro247Leu Uncertain significance Single submitter
- ADAD2 p.Pro29Arg Uncertain significance Single submitter
- ADAD2 p.Pro31Ser Uncertain significance Single submitter
- ADAD2 p.Pro326Leu Uncertain significance Single submitter
- ADAD2 p.Pro354Ala Uncertain significance Single submitter
- ADAD2 p.Pro365His Uncertain significance Single submitter
- ADAD2 p.Pro365Ser Uncertain significance Single submitter
- ADAD2 p.Pro434Ser Uncertain significance Single submitter
- ADAD2 p.Pro435Leu Uncertain significance Single submitter
- ADAD2 p.Pro573Leu Uncertain significance Single submitter
- ADAD2 p.Ser340Thr Uncertain significance Single submitter
- ADAD2 p.Ser356Leu Uncertain significance Single submitter
- ADAD2 p.Ser3Leu Uncertain significance Single submitter
- ADAD2 p.Ser430Leu Uncertain significance Single submitter
- ADAD2 p.Thr121Arg Uncertain significance Single submitter
- ADAD2 p.Thr481Ser Uncertain significance Single submitter
- ADAD2 p.Trp231Cys Uncertain significance Single submitter
- ADAD2 p.Trp58Cys Uncertain significance Single submitter
- ADAD2 p.Tyr538Cys Uncertain significance Single submitter
- ADAD2 p.Tyr553Cys Uncertain significance Single submitter
- ADAD2 p.Val382Leu Uncertain significance Single submitter
- ADAD2 p.Val534Ala Uncertain significance Single submitter
Predictors split 65
The independent predictors disagree with each other — read with care.
- ADAD2 p.Arg180Gln Likely benign Multiple submitters
- ADAD2 p.Ala124Glu Uncertain significance Single submitter
- ADAD2 p.Ala149Thr Uncertain significance Single submitter
- ADAD2 p.Ala149Val Likely benign Single submitter
- ADAD2 p.Ala158Thr Uncertain significance Single submitter
- ADAD2 p.Ala213Thr Uncertain significance Single submitter
- ADAD2 p.Ala346Thr Uncertain significance Single submitter
- ADAD2 p.Ala346Val Uncertain significance Single submitter
- ADAD2 p.Ala383Val Uncertain significance Single submitter
- ADAD2 p.Ala531Thr Uncertain significance Single submitter
- ADAD2 p.Ala81Thr Uncertain significance Single submitter
- ADAD2 p.Arg180Trp Uncertain significance Single submitter
- ADAD2 p.Arg18Cys Uncertain significance Single submitter
- ADAD2 p.Arg211His Uncertain significance Single submitter
- ADAD2 p.Arg248His Uncertain significance Single submitter
- ADAD2 p.Arg299Gly Uncertain significance Single submitter
- ADAD2 p.Arg30His Uncertain significance Single submitter
- ADAD2 p.Arg332His Uncertain significance Single submitter
- ADAD2 p.Arg461Trp Uncertain significance Single submitter
- ADAD2 p.Arg505His Uncertain significance Single submitter
- ADAD2 p.Arg557His Uncertain significance Single submitter
- ADAD2 p.Arg557Leu Uncertain significance Single submitter
- ADAD2 p.Arg82Trp Uncertain significance Single submitter
- ADAD2 p.Asp282Asn Uncertain significance Single submitter
- ADAD2 p.Asp433Asn Uncertain significance Single submitter
- ADAD2 p.Asp448His Uncertain significance Single submitter
- ADAD2 p.Glu546Lys Uncertain significance Single submitter
- ADAD2 p.Gly128Ser Uncertain significance Single submitter
- ADAD2 p.Gly251Ser Uncertain significance Single submitter
- ADAD2 p.Gly308Asp Uncertain significance Single submitter
- ADAD2 p.Gly324Arg Uncertain significance Single submitter
- ADAD2 p.Gly551Ala Uncertain significance Single submitter
- ADAD2 p.Gly72Glu Uncertain significance Single submitter
- ADAD2 p.Gly74Glu Uncertain significance Single submitter
- ADAD2 p.Leu120Val Uncertain significance Single submitter
- ADAD2 p.Leu293Met Uncertain significance Single submitter
- ADAD2 p.Leu297Phe Uncertain significance Single submitter
- ADAD2 p.Leu400Val Uncertain significance Single submitter
- ADAD2 p.Leu425Phe Uncertain significance Single submitter
- ADAD2 p.Leu518Val Uncertain significance Single submitter
- ADAD2 p.Leu560Val Uncertain significance Single submitter
- ADAD2 p.Leu562Pro Uncertain significance Single submitter
- ADAD2 p.Lys507Met Uncertain significance Single submitter
- ADAD2 p.Phe298Leu Uncertain significance Single submitter
- ADAD2 p.Pro112Leu Uncertain significance Single submitter
- ADAD2 p.Pro36Leu Uncertain significance Single submitter
- ADAD2 p.Pro378His Uncertain significance Single submitter
- ADAD2 p.Pro477His Uncertain significance Single submitter
- ADAD2 p.Pro515Ser Uncertain significance Single submitter
- ADAD2 p.Ser146Leu Uncertain significance Single submitter
- ADAD2 p.Ser174Phe Uncertain significance Single submitter
- ADAD2 p.Ser188Cys Uncertain significance Single submitter
- ADAD2 p.Ser188Tyr Uncertain significance Single submitter
- ADAD2 p.Ser228Leu Uncertain significance Single submitter
- ADAD2 p.Ser228Trp Uncertain significance Single submitter
- ADAD2 p.Ser267Asn Uncertain significance Single submitter
- ADAD2 p.Ser41Asn Uncertain significance Single submitter
- ADAD2 p.Ser449Cys Uncertain significance Single submitter
- ADAD2 p.Thr121Ala Likely benign Single submitter
- ADAD2 p.Thr443Ile Uncertain significance Single submitter
- ADAD2 p.Thr503Pro Uncertain significance Single submitter
- ADAD2 p.Val154Met Uncertain significance Single submitter
- ADAD2 p.Val460Ile Uncertain significance Single submitter
- ADAD2 p.Val506Met Uncertain significance Single submitter
- ADAD2 p.Val75Ile Uncertain significance Single submitter
All ADAD2 variants
Pathogenic 1
- p.Leu173fs Single submitter Non-obstructive azoospermia
Likely benign 16
- p.Arg180Gln Multiple submitters ⚠
- p.Ala149Val Single submitter ⚠
- p.Ala511Thr Single submitter
- p.Arg194Gln Single submitter
- p.Arg348His Single submitter
- p.Cys268Ser Single submitter
- p.Gln190Lys Single submitter
- p.Gly12= Single submitter
- p.Gly12Ser Single submitter
- p.Ser13Gly Single submitter
- p.Ser385= Single submitter
- p.Ser41Gly Single submitter
- p.Ser5Ala Single submitter
- p.Thr121Ala Single submitter ⚠
- p.Thr355Ser Single submitter
- p.Tyr351= Single submitter
Uncertain significance 161
- c.419-254A>G Single submitter
- c.419-262T>C Single submitter
- c.419-274C>T Single submitter
- c.419-334G>A Single submitter
- c.419-334G>T Single submitter
- c.419-376A>C Single submitter
- c.419-409G>A Single submitter
- c.734-21T>A Single submitter
- c.734-22G>A Single submitter
- c.734-24C>A Single submitter
- p.Ala124Glu Single submitter ⚠
- p.Ala149Thr Single submitter ⚠
- p.Ala158Thr Single submitter ⚠
- p.Ala198Val Single submitter ⚠
- p.Ala20Gly Single submitter ⚠
- p.Ala213Thr Single submitter ⚠
- p.Ala346Thr Single submitter ⚠
- p.Ala346Val Single submitter ⚠
- p.Ala383Val Single submitter ⚠
- p.Ala396Val Single submitter ⚠
- p.Ala401Glu Single submitter ⚠
- p.Ala42Ser Single submitter ⚠
- p.Ala463Val Single submitter ⚠
- p.Ala46Ser Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala511Val Single submitter ⚠
- p.Ala531Thr Single submitter ⚠
- p.Ala571Pro Single submitter ⚠
- p.Ala80Pro Single submitter ⚠
- p.Ala81Thr Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg180Trp Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg211His Single submitter ⚠
- p.Arg248His Single submitter ⚠
- p.Arg250Gly Single submitter ⚠
- p.Arg290Gly Single submitter ⚠
- p.Arg299Gly Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg332His Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg33Leu Single submitter ⚠
- p.Arg348Gly Single submitter ⚠
- p.Arg348Ser Single submitter ⚠
- p.Arg367His Single submitter ⚠
- p.Arg461Trp Single submitter ⚠
- p.Arg483Gly Single submitter ⚠
- p.Arg505His Single submitter ⚠
- p.Arg525Gly Single submitter ⚠
- p.Arg525Leu Single submitter ⚠
- p.Arg557His Single submitter ⚠
- p.Arg557Leu Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Asn341Ser Single submitter ⚠
- p.Asp282Asn Single submitter ⚠
- p.Asp433Asn Single submitter ⚠
- p.Asp448His Single submitter ⚠
- p.Cys177Tyr Single submitter ⚠
- p.Cys454Phe Single submitter ⚠
- p.Gln115Leu Single submitter ⚠
- p.Gln24His Single submitter ⚠
- p.Gln278Leu Single submitter ⚠
- p.Gln369Arg Single submitter ⚠
- p.Gln375His Single submitter ⚠
- p.Gln40Pro Single submitter ⚠
- p.Gln554Glu Single submitter ⚠
- p.Gln559His Single submitter ⚠
- p.Gln90Glu Single submitter ⚠
- p.Glu226Lys Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Glu476Lys Single submitter ⚠
- p.Glu497Lys Single submitter ⚠
- p.Glu546Gln Single submitter ⚠
- p.Glu546Lys Single submitter ⚠
- p.Gly103Val Single submitter ⚠
- p.Gly128Ser Single submitter ⚠
- p.Gly219Ser Single submitter ⚠
- p.Gly251Ser Single submitter ⚠
- p.Gly308Asp Single submitter ⚠
- p.Gly324Arg Single submitter ⚠
- p.Gly409Ser Single submitter ⚠
- p.Gly469Glu Single submitter ⚠
- p.Gly492Arg Single submitter ⚠
- p.Gly551Ala Single submitter ⚠
- p.Gly68Glu Single submitter ⚠
- p.Gly72Glu Single submitter ⚠
- p.Gly74Glu Single submitter ⚠
- p.Gly7Val Single submitter ⚠
- p.Gly88Glu Single submitter ⚠
- p.His362Gln Single submitter ⚠
- p.Ile205Leu Single submitter ⚠
- p.Ile246Leu Single submitter ⚠
- p.Leu104Pro Single submitter ⚠
- p.Leu120Val Single submitter ⚠
- p.Leu293Met Single submitter ⚠
- p.Leu297Phe Single submitter ⚠
- p.Leu400Val Single submitter ⚠
- p.Leu425Phe Single submitter ⚠
- p.Leu427Val Single submitter ⚠
- p.Leu464Pro Single submitter ⚠
- p.Leu491Met Single submitter ⚠
- p.Leu518Val Single submitter ⚠
- p.Leu560Val Single submitter ⚠
- p.Leu562Pro Single submitter ⚠
- p.Leu87Val Single submitter ⚠
- p.Lys109Arg Single submitter ⚠
- p.Lys330Asn Single submitter ⚠
- p.Lys507Met Single submitter ⚠
- p.Lys549Glu Single submitter ⚠
- p.Met91Ile Single submitter ⚠
- p.Met91Thr Single submitter ⚠
- p.Phe298Leu Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Pro100Arg Single submitter ⚠
- p.Pro100Ser Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro157Arg Single submitter ⚠
- p.Pro196Ala Single submitter ⚠
- p.Pro247Leu Single submitter ⚠
- p.Pro29Arg Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro354Ala Single submitter ⚠
- p.Pro365His Single submitter ⚠
- p.Pro365Ser Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro378His Single submitter ⚠
- p.Pro434Ser Single submitter ⚠
- p.Pro435Leu Single submitter ⚠
- p.Pro477His Single submitter ⚠
- p.Pro515Ser Single submitter ⚠
- p.Pro573Leu Single submitter ⚠
- p.Ser146Leu Single submitter ⚠
- p.Ser174Phe Single submitter ⚠
- p.Ser188Cys Single submitter ⚠
- p.Ser188Tyr Single submitter ⚠
- p.Ser228Leu Single submitter ⚠
- p.Ser228Trp Single submitter ⚠
- p.Ser267Asn Single submitter ⚠
- p.Ser340Thr Single submitter ⚠
- p.Ser356Leu Single submitter ⚠
- p.Ser3Leu Single submitter ⚠
- p.Ser41Asn Single submitter ⚠
- p.Ser430Leu Single submitter ⚠
- p.Ser449Cys Single submitter ⚠
- p.Thr121Arg Single submitter ⚠
- p.Thr443Ile Single submitter ⚠
- p.Thr481Ser Single submitter ⚠
- p.Thr503Pro Single submitter ⚠
- p.Trp231Cys Single submitter ⚠
- p.Trp58Cys Single submitter ⚠
- p.Tyr538Cys Single submitter ⚠
- p.Tyr553Cys Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val382Leu Single submitter ⚠
- p.Val460Ile Single submitter ⚠
- p.Val506Met Single submitter ⚠
- p.Val534Ala Single submitter ⚠
- p.Val75Ile Single submitter ⚠