ADAM11 — 105 ClinVar variants
All ClinVar germline ADAM11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
1 Benign · 7 Likely benign · 97 Uncertain significance
Full ADAM11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ADAM11 p.Ala148Thr Uncertain significance Single submitter
- ADAM11 p.Ala214Ser Uncertain significance Single submitter
- ADAM11 p.Ala214Thr Uncertain significance Single submitter
- ADAM11 p.Ala326Thr Uncertain significance Single submitter
- ADAM11 p.Ala342Val Uncertain significance Single submitter
- ADAM11 p.Ala609Thr Uncertain significance Single submitter
- ADAM11 p.Arg218Pro Uncertain significance Single submitter
- ADAM11 p.Arg228His Uncertain significance Single submitter
- ADAM11 p.Arg311Gln Uncertain significance Single submitter
- ADAM11 p.Arg493Ser Uncertain significance Single submitter
- ADAM11 p.Arg552Gln Uncertain significance Single submitter
- ADAM11 p.Arg683His Uncertain significance Single submitter
- ADAM11 p.Arg684Gln Uncertain significance Single submitter
- ADAM11 p.Arg72His Uncertain significance Single submitter
- ADAM11 p.Asn694Lys Uncertain significance Single submitter
- ADAM11 p.Asp482Glu Uncertain significance Single submitter
- ADAM11 p.Asp703Glu Uncertain significance Single submitter
- ADAM11 p.Cys394Tyr Uncertain significance Single submitter
- ADAM11 p.Cys491Gly Uncertain significance Single submitter
- ADAM11 p.Gln124His Uncertain significance Single submitter
- ADAM11 p.Gln627Arg Uncertain significance Single submitter
- ADAM11 p.Gln701Glu Uncertain significance Single submitter
- ADAM11 p.Gln85Arg Uncertain significance Single submitter
- ADAM11 p.Gly199Arg Uncertain significance Single submitter
- ADAM11 p.Gly29Arg Uncertain significance Single submitter
- ADAM11 p.Gly341Arg Uncertain significance Single submitter
- ADAM11 p.Gly60Glu Uncertain significance Single submitter
- ADAM11 p.Gly679Ser Uncertain significance Single submitter
- ADAM11 p.Gly722Arg Uncertain significance Single submitter
- ADAM11 p.Gly722Glu Uncertain significance Single submitter
- ADAM11 p.His235Tyr Uncertain significance Single submitter
- ADAM11 p.His560Arg Uncertain significance Single submitter
- ADAM11 p.Ile167Val Uncertain significance Single submitter
- ADAM11 p.Leu108Phe Uncertain significance Single submitter
- ADAM11 p.Leu306Arg Uncertain significance Single submitter
- ADAM11 p.Met290Val Uncertain significance Single submitter
- ADAM11 p.Met484Lys Uncertain significance Single submitter
- ADAM11 p.Pro18Ser Uncertain significance Single submitter
- ADAM11 p.Pro79Leu Uncertain significance Single submitter
- ADAM11 p.Ser263Asn Uncertain significance Single submitter
- ADAM11 p.Thr191Ile Uncertain significance Single submitter
- ADAM11 p.Thr338Met Uncertain significance Single submitter
- ADAM11 p.Trp7Cys Uncertain significance Single submitter
Predictors split 55
The independent predictors disagree with each other — read with care.
- ADAM11 p.Thr717Met Uncertain significance Multiple submitters
- ADAM11 p.Ala147Thr Uncertain significance Single submitter
- ADAM11 p.Ala561Val Uncertain significance Single submitter
- ADAM11 p.Ala741Thr Uncertain significance Single submitter
- ADAM11 p.Arg119Trp Uncertain significance Single submitter
- ADAM11 p.Arg190Trp Uncertain significance Single submitter
- ADAM11 p.Arg218Trp Uncertain significance Single submitter
- ADAM11 p.Arg284His Uncertain significance Single submitter
- ADAM11 p.Arg311Trp Uncertain significance Single submitter
- ADAM11 p.Arg317Trp Uncertain significance Single submitter
- ADAM11 p.Arg550Gln Uncertain significance Single submitter
- ADAM11 p.Arg552Trp Uncertain significance Single submitter
- ADAM11 p.Arg583Cys Uncertain significance Single submitter
- ADAM11 p.Arg611Gln Uncertain significance Single submitter
- ADAM11 p.Arg611Trp Uncertain significance Single submitter
- ADAM11 p.Arg665Cys Uncertain significance Single submitter
- ADAM11 p.Arg665His Uncertain significance Single submitter
- ADAM11 p.Arg70Ser Uncertain significance Single submitter
- ADAM11 p.Asn694Ser Uncertain significance Single submitter
- ADAM11 p.Asp303Gly Uncertain significance Single submitter
- ADAM11 p.Cys205Tyr Uncertain significance Single submitter
- ADAM11 p.Glu509Lys Uncertain significance Single submitter
- ADAM11 p.Glu509Val Uncertain significance Single submitter
- ADAM11 p.Glu682Lys Uncertain significance Single submitter
- ADAM11 p.Gly35Cys Uncertain significance Single submitter
- ADAM11 p.Gly628Ser Uncertain significance Single submitter
- ADAM11 p.Gly643Ser Uncertain significance Single submitter
- ADAM11 p.Ile419Asn Uncertain significance Single submitter
- ADAM11 p.Ile735Val Uncertain significance Single submitter
- ADAM11 p.Leu662Gln Uncertain significance Single submitter
- ADAM11 p.Lys138Asn Uncertain significance Single submitter
- ADAM11 p.Lys593Asn Uncertain significance Single submitter
- ADAM11 p.Met313Val Uncertain significance Single submitter
- ADAM11 p.Phe624Leu Uncertain significance Single submitter
- ADAM11 p.Pro143Leu Likely benign Single submitter
- ADAM11 p.Pro183Leu Uncertain significance Single submitter
- ADAM11 p.Pro185Leu Uncertain significance Single submitter
- ADAM11 p.Pro50Leu Uncertain significance Single submitter
- ADAM11 p.Pro657Ser Uncertain significance Single submitter
- ADAM11 p.Pro719Leu Uncertain significance Single submitter
- ADAM11 p.Ser110Trp Uncertain significance Single submitter
- ADAM11 p.Ser337Arg Uncertain significance Single submitter
- ADAM11 p.Ser620Gly Uncertain significance Single submitter
- ADAM11 p.Ser718Phe Uncertain significance Single submitter
- ADAM11 p.Thr549Ser Uncertain significance Single submitter
- ADAM11 p.Thr721Met Uncertain significance Single submitter
- ADAM11 p.Tyr543Ser Uncertain significance Single submitter
- ADAM11 p.Val113Met Uncertain significance Single submitter
- ADAM11 p.Val260Ile Uncertain significance Single submitter
- ADAM11 p.Val286Ile Uncertain significance Single submitter
- ADAM11 p.Val556Ile Uncertain significance Single submitter
- ADAM11 p.Val596Met Uncertain significance Single submitter
- ADAM11 p.Val638Leu Uncertain significance Single submitter
- ADAM11 p.Val750Ile Uncertain significance Single submitter
- ADAM11 p.Val89Ile Uncertain significance Single submitter
All ADAM11 variants
Benign 1
- p.Gly35= Single submitter
Likely benign 7
- p.Glu291= Single submitter
- p.Gly178Glu Single submitter
- p.Gly34Arg Single submitter
- p.Gly35Arg Single submitter
- p.Gly35Ser Single submitter
- p.Leu198= Single submitter
- p.Pro143Leu Single submitter ⚠
Uncertain significance 97
- p.Thr717Met Multiple submitters ⚠
- p.Ala147Thr Single submitter ⚠
- p.Ala148Thr Single submitter ⚠
- p.Ala214Ser Single submitter ⚠
- p.Ala214Thr Single submitter ⚠
- p.Ala326Thr Single submitter ⚠
- p.Ala342Val Single submitter ⚠
- p.Ala561Val Single submitter ⚠
- p.Ala609Thr Single submitter ⚠
- p.Ala741Thr Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg190Trp Single submitter ⚠
- p.Arg218Pro Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg311Gln Single submitter ⚠
- p.Arg311Trp Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg493Ser Single submitter ⚠
- p.Arg550Gln Single submitter ⚠
- p.Arg552Gln Single submitter ⚠
- p.Arg552Trp Single submitter ⚠
- p.Arg583Cys Single submitter ⚠
- p.Arg611Gln Single submitter ⚠
- p.Arg611Trp Single submitter ⚠
- p.Arg665Cys Single submitter ⚠
- p.Arg665His Single submitter ⚠
- p.Arg683His Single submitter ⚠
- p.Arg684Gln Single submitter ⚠
- p.Arg70Ser Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Asn694Lys Single submitter ⚠
- p.Asn694Ser Single submitter ⚠
- p.Asp303Gly Single submitter ⚠
- p.Asp482Glu Single submitter ⚠
- p.Asp703Glu Single submitter ⚠
- p.Cys205Tyr Single submitter ⚠
- p.Cys394Tyr Single submitter ⚠
- p.Cys491Gly Single submitter ⚠
- p.Gln124His Single submitter ⚠
- p.Gln627Arg Single submitter ⚠
- p.Gln701Glu Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Glu509Lys Single submitter ⚠
- p.Glu509Val Single submitter ⚠
- p.Glu682Lys Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly341Arg Single submitter ⚠
- p.Gly35Cys Single submitter ⚠
- p.Gly60Glu Single submitter ⚠
- p.Gly628Ser Single submitter ⚠
- p.Gly643Ser Single submitter ⚠
- p.Gly679Ser Single submitter ⚠
- p.Gly722Arg Single submitter ⚠
- p.Gly722Glu Single submitter ⚠
- p.His235Tyr Single submitter ⚠
- p.His560Arg Single submitter ⚠
- p.Ile167Val Single submitter ⚠
- p.Ile419Asn Single submitter ⚠
- p.Ile735Val Single submitter ⚠
- p.Leu108Phe Single submitter ⚠
- p.Leu306Arg Single submitter ⚠
- p.Leu662Gln Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Lys593Asn Single submitter ⚠
- p.Met290Val Single submitter ⚠
- p.Met313Val Single submitter ⚠
- p.Met484Lys Single submitter ⚠
- p.Phe624Leu Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro185Leu Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Pro657Ser Single submitter ⚠
- p.Pro719Leu Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Ser110Trp Single submitter ⚠
- p.Ser263Asn Single submitter ⚠
- p.Ser337Arg Single submitter ⚠
- p.Ser620Gly Single submitter ⚠
- p.Ser718Phe Single submitter ⚠
- p.Thr191Ile Single submitter ⚠
- p.Thr338Met Single submitter ⚠
- p.Thr549Ser Single submitter ⚠
- p.Thr721Met Single submitter ⚠
- p.Trp7Cys Single submitter ⚠
- p.Tyr543Ser Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val260Ile Single submitter ⚠
- p.Val286Ile Single submitter ⚠
- p.Val556Ile Single submitter ⚠
- p.Val596Met Single submitter ⚠
- p.Val638Leu Single submitter ⚠
- p.Val750Ile Single submitter ⚠
- p.Val89Ile Single submitter ⚠